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Adaptive evolution is substantially impeded by Hill-Robertson interference in Drosophila
Castellano Esteve, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Coronado-Zamora, Marta (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Campos, Jose L. (University of Edinburgh. Institute of Evolutionary Biology, School of Biological Sciences)
Barbadilla Prados, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Eyre-Walker, Adam (University of Sussex. Centre for the Study of Evolution, School of Life Sciences)
Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

Date: 2015
Abstract: Hill-Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive evolution for any given genome. In this work, we estimate how much HRi impedes the rate of adaptive evolution in the coding genome of Drosophila melanogaster. We compiled a data set of 6,141 autosomal protein-coding genes from Drosophila, from which polymorphism levels in D. melanogaster and divergence out to D. yakuba were estimated. The rate of adaptive evolution was calculated using a derivative of the McDonald-Kreitman test that controls for slightly deleterious mutations. We find that the rate of adaptive amino acid substitution at a given position of the genome is positively correlated to both the rate of recombination and the mutation rate, and negatively correlated to the gene density of the region. These correlations are robust to controlling for each other, for synonymous codon bias and for gene functions related to immune response and testes. We show that HRi diminishes the rate of adaptive evolution by approximately 27%. Interestingly, genes with low mutation rates embedded in gene poor regions lose approximately 17% of their adaptive substitutions whereas genes with high mutation rates embedded in gene rich regions lose approximately 60%. We conclude that HRi hampers the rate of adaptive evolution in Drosophila and that the variation in recombination, mutation, and gene density along the genome affects the HRi effect.
Note: Número d'acord de subvenció MINECO/AP2008/02405
Note: Número d'acord de subvenció MINECO/BUF2013/42649-P
Note: Número d'acord de subvenció AGAUR/2014/SGR/1346
Note: Número d'acord de subvenció AGAUR/2015/FI-DGR
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Hill-Robertson ; Adaptation ; Recombination ; Mutation ; Drosophila ; Gene density
Published in: Molecular biology and evolution, Vol. 33, Núm. 2 (October 2015) , p. 442-455, ISSN 1537-1719

DOI: 10.1093/molbev/msv236
PMID: 26494843

14 p, 652.3 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles

 Record created 2018-01-31, last modified 2020-09-07

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