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| Página principal > Artículos > Artículos publicados > Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions |
(Institut Hospital del Mar d'Investigacions Mèdiques) (Hospital General Universitario de Valencia) (Universidad de Navarra. Departamento de Bioquímica y Genética) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital Universitario de Salamanca. Centro de Investigación del Cáncer) (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) (Laboratorio de Citogenética, Servicio de Hematología, Fundación Jiménez Díaz, Madrid, Spain) (Institut Hospital del Mar d'Investigacions Mèdiques) (Hospital Universitari Vall d'Hebron) (Hospital del Mar (Barcelona, Catalunya)) (Hospital del Mar (Barcelona, Catalunya)) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut d'Investigació Biomèdica Sant Pau) (Hospital Universitari Vall d'Hebron) (Institut d'Investigacions Biomèdiques August Pi i Sunyer)| Fecha: | 2017 |
| Resumen: | Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. In all, 99/1045 (9. 5%) patients displayed a CK. Despite ATM and TP53 deletions were more common in CK (25% vs 7%; P < 0. 001; 40% vs 5%; P < 0. 001, respectively), only 44% (40/90) patients with TP53 deletions showed a CK. CK group showed a significant higher two-year cumulative incidence of treatment (48% vs 20%; P < 0. 001), as well as a shorter overall survival (OS) (79 mo vs not reached; P < 0. 001). When patients were categorized regarding CK and HR-FISH, those with both characteristics showed the worst median OS (52 mo) being clearly distinct from those non-CK and non-HR-FISH (median not reached), but no significant differences were detected between cases with only CK or HR-FISH. Both CK and TP53 deletion remained statistically significant in the multivariate analysis for OS. In conclusion, CK group is globally associated with advanced disease and poor prognostic markers. Further investigation in larger cohorts with CK lacking HR-FISH is needed to elucidate which mechanisms underlie the poor outcome of this subgroup. |
| Ayudas: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-585 Instituto de Salud Carlos III PI11-01621 Instituto de Salud Carlos III PI15-00437 Instituto de Salud Carlos III RD12-0036-0044 Instituto de Salud Carlos III RD12/0036-0069 Instituto de Salud Carlos III PT13/0010-0005 |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | CLL ; Complex karyotype ; ATM deletion ; TP53 deletion |
| Publicado en: | Oncotarget, Vol. 8 (april 2017) , p. 54297-54303, ISSN 1949-2553 |
