Google Scholar: citations
GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron)
Mendióroz, Maite (Hospital Universitari Vall d'Hebron)
Giralt, Dolors (Hospital Universitari Vall d'Hebron)
Nafría, Cristina (Hospital Universitari Vall d'Hebron)
Garcia, Elena (Fundació Docència i Recerca Mútua Terrassa)
Carrera, Caty (Hospital Universitari Vall d'Hebron)
Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mútua Terrassa)
Domingues-Montanari, Sophie (Hospital Universitari Vall d'Hebron)
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron)
Ribo, Marc (Hospital Universitari Vall d'Hebron)
Castellanos, María del Mar (Hospital Universitari de Girona Doctor Josep Trueta)
Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau)
Freijo, Mari Mar (Hospital de Basurto (Bilbao, Biscaia))
Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya))
Rubiera, Marta (Hospital Universitari Vall d'Hebron)
Álvarez Sabín, José (Hospital Universitari Vall d'Hebron)
Molina, Carlos A. (Hospital Universitari Vall d'Hebron)
Font, Maria Angels (Hospital Universitari de Bellvitge)
Grau Olivares, Marta (Hospital del Sagrat Cor (Barcelona, Catalunya))
Palomeras, Ernest (Hospital de Mataró. Consorci Sanitari del Maresme)
Pérez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martinez Zabaleta, Maite (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Masjuan, Jaime (Hospital Universitario Ramón y Cajal (Madrid))
Moniche, Francisco (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Cánovas, David (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Piñana, Carlos (Hospital Universitario Virgen de las Nieves (Granada))
Purroy, Francisco (Hospital Arnau de Vilanova (Lleida, Catalunya))
Cocho, Dolores (Hospital General de Granollers)
Navas, Inma (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Tejero, Carlos (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Aymerich, Nuria (Complejo Hospitalario de Navarra)
Cullell, Natalia (Fundació Docència i Recerca Mútua Terrassa)
Muiño, Elena (Fundació Docència i Recerca Mútua Terrassa)
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta)
Rubio, Francisco (Hospital Universitari de Bellvitge)
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Roquer González, Jaume (Hospital del Mar (Barcelona, Catalunya))
Arenillas, Juan F.. (Hospital Clínico Universitario de Valladolid)
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau)
Keene, Keith (Center for Health Disparities. East Carolina University)
Chen, Wei-Min (University of Virginia)
Worrall, Bradford (University of Virginia)
Sale, Michele (Center for Public Health Genomics, University of Virginia)
Arboix, Adrià (Hospital del Sagrat Cor (Barcelona, Catalunya))
Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Montaner, Joan (Hospital Universitari Vall d'Hebron)
GRECOSstudy group
Universitat Autònoma de Barcelona

Date: 2017
Abstract: Background and Purpose-Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. Methods-We analyzed 256 polymorphisms from 115 candidate genes in three patient cohorts comprising 4,482 IS or TIA patients. The discovery cohort was prospectively recruited and included 1,494 patients, 6. 2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2,988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score), and generated risk groups using a classification tree method. Results-The analyses revealed that rs1800801 in the MGP gene (HR: 1. 33, p= 9×10−03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1. 305), however it was not significantly associated in a North American cohort (n=1. 683). The GRECOS score predicted new IS (p=3. 2×10−09) and could classify patients, from low risk of stroke recurrence (1. 9%) to high risk (12. 6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared to previous SPI-II score (p=0. 03). Conclusions-The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
Grants: Instituto de Salud Carlos III PI15/01978
Instituto de Salud Carlos III CP12/03298
Instituto de Salud Carlos III RD12/0042/0020
Note: Altres ajuts: This study was funded by Marato TV3, by the Spanish stroke research network (INVICTUS-PLUS) and by Generacion project (PI15/01978) Instituto de Salud Carlos III. Dr Fernández-Cadenas is supported by the Miguel Servet program (CP12/03298), Instituto de Salud Carlos III. Several groups participate in the International Stroke Genetics Consortium and the Spanish Stroke Genetics Consortium. The Hospital del Mar is supported by Spain's Ministry of Health (III FEDER, RD12/0042/0020). Study recruitment and collection of data sets for the VISP trial were supported by a grant (R01 NS34447; PI James Toole) from the National Institute of Neurological Disorders and Stroke (NINDS). Genome-wide association studies genotyping (U01 HG004438l; PI David Valle), funded by the National Human Genome Research Institute and the Genomics and Randomized Trials (GARNET) Network (U01HG00516-03; co-PI Michèle M. Sale and Bradford B. Worrall), and genetic data cleaning was provided by the GARNET Coordinating Center (U01HG005157; PI Bruce S. Weir)
Rights: Tots els drets reservats.
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Stroke recurrence ; Genetics
Published in: Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153, ISSN 1524-4628

DOI: 10.1161/STROKEAHA.116.014322
PMID: 28411264


15 p, 517.3 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-10-10, last modified 2024-02-29



   Favorit i Compartir