Web of Science: 420 cites, Scopus: 439 cites, Google Scholar: cites,
Great ape genetic diversity and population history
Prado-Martinez, J. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Sudmant, P.H. (Department of Genome Sciences. University of Washington)
Kidd, J.M. (Department of Genetics. Stanford University)
Li, H. (Department of Genetics. Harvard Medical School, Boston)
Kelley, J.L. (Department of Genetics. Stanford University)
Lorente-Galdos, B. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Veeramah, K.R. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
Woerner, A.E. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
O'Connor, T.D. (Department of Genome Sciences. University of Washington)
Santpere, G. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Cagan, A. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology)
Theunert, C. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology)
Casals, F. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Laayouni, H. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Munch, K. (Bioinformatics Research Centre. Aarhus University)
Hobolth, A. (Bioinformatics Research Centre. Aarhus University)
Halager, A.E. (Bioinformatics Research Centre. Aarhus University)
Malig, M. (Department of Genome Sciences. University of Washington)
Hernández Rodríguez, José (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Hernando-Herraez, I. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Prüfer, K. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology)
Pybus, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Johnstone, L. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
Lachmann, M. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology)
Alkan, C. (Bilkent University. Faculty of Engineering)
Twigg, D. (Department of Human Genetics. University of Michigan)
Petit, N. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Baker, C. (Department of Genome Sciences. University of Washington)
Hormozdiari, F. (Department of Genome Sciences. University of Washington)
Fernandez-Callejo, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Dabad, M. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Wilson, M.L. (Department of Anthropology. University of Minnesota)
Stevison, L. (Institute for Human Genetics. University of California San Francisco)
Camprubí Sánchez, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Carvalho, T. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Ruiz-Herrera Moreno, Aurora (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Vives, L. (Department of Genome Sciences. University of Washington)
Mele, M. (Centre for Genomic Regulation (CRG))
Abello, Teresa. (Parc Zoològic de Barcelona)
Kondova, Ivanela (Biomedical Primate Research Centre)
Bontrop, R.E. (Biomedical Primate Research Centre)
Pusey, A. (Department of Evolutionary Anthropology. Duke University)
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Kiyang, J.A. (Limbe Wildlife Centre)
Bergl, R.A. (North Carolina Zoological Park)
Lonsdorf, E. (Department of Psychology. Franklin and Marshall College)
Myers, S. (Department of Statistics. Oxford University)
Ventura, M. (Department of Genetics and Microbiology. University of Bari)
Gagneux, P. (Department of Cellular and Molecular Medicine. University of California San Diego)
Comas, D. (Institut de Biologia Evolutiva. CSIC-Universitat Pompeu Fabra. PRBB)
Siegismund, H. (Department of Biology, Bioinformatics. University of Copenhagen)
Blanc, J. (Centro Nacional de Análisis Genómico (CNAG). PCB)
Agueda-Calpena, L. (Centro Nacional de Análisis Genómico (CNAG). PCB)
Gut, M. (Centro Nacional de Análisis Genómico (CNAG). PCB)
Fulton, L. (Genome Sequencing Center. Washington University School of Medicine)
Tishkoff, S.A. (Department of Biology and Genetics. University of Pennsylvania)
Mullikin, J.C. (National Institutes of Health Intramural Sequencing Center (NISC))
Wilson, R.K. (Genome Sequencing Center. Washington University School of Medicine)
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Gonder, M.K. (University at Albany)
Ryder, O.A. (Genetics Division. San Diego Zoo's Institute for Conservation Research)
Hahn, B.H. (Departments of Medicine and Microbiology. Perelman School of Medicine. University of Pennsylvania)
Navarro, A. (Institució Catalana de Recerca i Estudis Avançats (ICREA))
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Andrés, A.M. (Department of Evolutionary Genetics. Max Planck Institute for Evolutionary Anthropology)
Wall, J.D. (Institute for Human Genetics. University of California San Francisco)
Bustamante, C.D. (Department of Genetics. Stanford University)
Hammer, M.F. (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
Eichler, E.E. (Howard Hughes Medical Institute)
Marques-Bonet, Tomas. (Institució Catalana de Recerca i Estudis Avançats (ICREA))

Data: 2013
Resum: Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88. 8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.
Nota: Número d'acord de subvenció EC/FP7/260372
Nota: Número d'acord de subvenció EC/FP7/233297
Nota: Número d'acord de subvenció MICINN/BFU2012-38236
Nota: Número d'acord de subvenció MICINN/BFU2011-28549
Nota: Número d'acord de subvenció MICINN/BFU2010-19443
Nota: Número d'acord de subvenció MICINN/BFU2009-13409-C02-02
Nota: Número d'acord de subvenció MINECO/CGL-2010-20170
Nota: Número d'acord de subvenció AGAUR/2009/SGR-1101
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: Evolution ; Evolutionary biology
Publicat a: Nature, Vol. 499, issue 7459 (July 2013) , p. 471-475, ISSN 1476-4687

DOI: 10.1038/nature12228
PMID: 23823723


5 p, 788.2 KB

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