Great ape genetic diversity and population history
Prado-Martinez, Javier (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Sudmant, Peter H. (Department of Genome Sciences. University of Washington)
Kidd, Jeffrey (Department of Genetics. Stanford University)
Li, Heng (Department of Genetics. Harvard Medical School, Boston)
Kelley, Joanna (Department of Genetics. Stanford University)
Lorente-Galdos, Belen (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Veeramah, Krishna (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
Woerner, August (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
O'Connor, Timothy (Department of Genome Sciences. University of Washington)
Santpere, Gabriel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Cagan, Alexander (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Theunert, Christoph (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Casals, Ferran (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Laayouni, Hafid (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Munch Terkelsen, Kasper (Aarhus University. Bioinformatics Research Centre)
Hobolth, Asger (Aarhus University. Bioinformatics Research Centre)
Halager, Anders E. (Aarhus University. Bioinformatics Research Centre)
Malig, Maika (Department of Genome Sciences. University of Washington)
Hernandez-Rodriguez, Jessica (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Hernando-Herraez, Irene (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Prüfer, Kay (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Pybus, Marc (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Johnstone, Laurel (Arizona Research Laboratories. Division of Biotechnology. University of Arizona)
Lachmann, Michael (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Alkan, Can (Bilkent University. Faculty of Engineering)
Twigg, Dorina (Department of Human Genetics. University of Michigan)
Petit Marty, Natalia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Baker, Carl (Department of Genome Sciences. University of Washington)
Hormozdiari, Fereydoun (University of Washington. Department of Genome Sciences)
Fernández, Marcos (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Dabad, Marc (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Wilson, Michael L. (Department of Anthropology. University of Minnesota)
Stevison, Laurie (Institute for Human Genetics. University of California San Francisco)
Camprubí Sánchez, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Carvalho, Tiago (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Vives, Laura T. (Department of Genome Sciences. University of Washington)
Mele, Marta (Centre de Regulació Genòmica)
Abelló, María Teresa. (Zoo de Barcelona)
Kondova, Ivanela (Biomedical Primate Research Centre)
Bontrop, Ronald (Biomedical Primate Research Centre)
Pusey, Anne E (Duke University. Department of Evolutionary Anthropology)
Lankester, Felix (Washington State University. Paul G. Allen School for Global Animal Health)
Kiyang, John A. (Limbe Wildlife Centre)
Bergl, Richard A. (North Carolina Zoological Park)
Lonsdorf, E. (Franklin and Marshall College. Department of Psychology)
Myers, S. (Oxford University. Department of Statistics)
Ventura, M. (University of Bari. Department of Genetics and Microbiology)
Gagneux, Pascal (University of California San Diego. Department of Cellular and Molecular Medicine)
Comas, D. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Siegismund, H. (University of Copenhagen Department of Biology, Bioinformatics)
Blanc, Julie (Centro Nacional de Análisis Genómico (CNAG). PCB)
Agueda Calpena, Lidia (Centro Nacional de Análisis Genómico (CNAG). PCB)
Gut, Marta (Centro Nacional de Análisis Genómico (CNAG). PCB)
Fulton, L. A (Washington University School of Medicine. Genome Sequencing Center)
Tishkoff, S. A. (University of Pennsylvania. Department of Biology and Genetics)
Mullikin, J. C. (National Institutes of Health Intramural Sequencing Center (Bethesda, Estats Units d'Amèrica))
Wilson, R. K. (Washington University School of Medicine. Genome Sequencing Center)
Gut, I. G. (Centro Nacional de Análisis Genómico (CNAG). PCB)
Gonder, M. K. (University at Albany)
Ryder, O. A. (Genetics Division. San Diego Zoo's Institute for Conservation Research)
Hahn, B. H. (University of Pennsylvania. Departments of Medicine and Microbiology)
Navarro, Arcadi, 1969- (Institució Catalana de Recerca i Estudis Avançats)
Akey, J. M. (University of Washington. Department of Genome Sciences)
Bertranpetit, Jaume (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Reich, D. (Harvard Medical School. Department of Genetics)
Mailund, Thomas (Aarhus University. Bioinformatics Research Centre)
Schierup, Mikkel Heide (Aarhus University. Department of Bioscience)
Hvilsom, Christina (Copenhagen Zoo)
Andrés, A. M. (Max Planck Institute for Evolutionary Anthropology. Department of Evolutionary Genetics)
Wall, J. D. (University of California San Francisco. Institute for Human Genetics)
Bustamante, Carlos D (Stanford University. Department of Genetics)
Hammer, M. F. (University of Arizona. Arizona Research Laboratories. Division of Biotechnology)
Eichler, Evan E (Howard Hughes Medical Institute)
Marques-Bonet, Tomas 1975- (Institució Catalana de Recerca i Estudis Avançats)

Data:	2013
Resum:	Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88. 8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.
Ajuts:	European Commission 260372 European Commission 233297 Ministerio de Ciencia e Innovación BFU2012-38236 Ministerio de Ciencia e Innovación BFU2011-28549 Ministerio de Ciencia e Innovación BFU2010-19443 Ministerio de Ciencia e Innovación BFU2009-13409-C02-02 Ministerio de Economía y Competitividad CGL-2010-20170 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1101
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Evolution ; Evolutionary biology
Publicat a:	Nature, Vol. 499, issue 7459 (July 2013) , p. 471-475, ISSN 1476-4687

DOI: 10.1038/nature12228
PMID: 23823723

5 p, 788.2 KB

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