Roadmap on nanomedicine for the central nervous system
Ciofani, Gianni (Italian Institute of Technology)
Campisi, Marco (Polytechnic University of Turin)
Mattu, Clara (Polytechnic University of Turin)
Kamm, Roger D. (Massachusetts Institute of Technology)
Chiono, Valeria (Polytechnic University of Turin)
Raynold, Aji Alex Moothedathu (University of Coimbra)
Freitas, João S. (University of Coimbra)
Redolfi Riva, Eugenio (Scuola Superiore Sant'Anna)
Micera, Silvestro (Scuola Superiore Sant'Anna)
Pucci, Carlotta (Italian Institute of Technology)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Sierri, Giulia (University of Milano-Bicocca)
Re, Francesca (University of Milano-Bicocca)
Wunderlich, Hannah (Technical University of Munich)
Kumari, Prachi (Technical University of Munich)
Kozielski, Kristen L. (Technical University of Munich)
Chami, Mounia (Institut de Pharmacologie Moléculaire et Cellulaire)
Marino, Attilio (Italian Institute of Technology)
Ferreira, Lino (University of Coimbra)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Date:	2023
Abstract:	In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.
Grants:	European Commission 824071 Agencia Estatal de Investigación RTI2018-098027-B-C21 Agencia Estatal de Investigación RTI2018-098027-B-C22 Ministerio de Ciencia e Innovación PID2021-127983OB-C21 Ministerio de Ciencia e Innovación PID2021-127983OB-C22 Ministerio de Ciencia e Innovación RED2018-102471-T Ministerio de Ciencia e Innovación SEV-2017-0706
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Blood-brain barrier ; Central nervous system ; Drug delivery ; Introductions ; Nanomedicines ; Roadmap
Published in:	JPhys materials, Vol. 6, Issue 2 (April 2023) , art. 22501, ISSN 2515-7639

DOI: 10.1088/2515-7639/acab88

40 p, 6.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles