Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis
Palau, Núria (Vall d'Hebron Institut de Recerca (VHIR))
Julià Cano, Antonio (Vall d'Hebron Institut de Recerca (VHIR))
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau)
Fonseca, Eduardo (Hospital Abente y Lago)
Fernández, Emilia (Hospital Universitario de Salamanca)
López Lasanta, María (Vall d'Hebron Institut de Recerca (VHIR))
Tortosa, Raül (Vall d'Hebron Institut de Recerca (VHIR))
Marsal, Sara (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2013
Abstract:	Background: Psoriasis is a chronic autoimmune disease in which T cells have a predominant role in initiating and perpetuating the chronic inflammation in skin. However, the mechanisms that regulate T cell activation in psoriasis are still incompletely understood. The objective of the present study was to characterize the main genetic pathways associated with T cell activation in psoriasis. Results: Gene expression profiles from in vitro activated T cells were obtained from 17 psoriasis patients and 7 healthy controls using Illumina HT-12 v4 microarrays. From a total of 47,321 analyzed transcripts, 42 genes were found to be differentially expressed between psoriasis and controls (FDR p-value < 0. 1, absolute fold-change.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gene expression ; Gene network ; Genetic pathway ; Microarray ; Psoriasis ; T cell
Published in:	BMC genomics, Vol. 14 Núm. 1 (25 2013) , p. 825, ISSN 1471-2164

DOI: 10.1186/1471-2164-14-825
PMID: 24267790

13 p, 547.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles