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Articles 350 records found  beginprevious126 - 135nextend  jump to record: Search took 0.00 seconds. 
126.
13 p, 1.1 MB Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity / Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Robinson, Lei Z. (Scripps Research Institute) ; Pereira-Henriques, Alda (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Ferreira, Nelson (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Huertas, Oscar (SOM-Biotech) ; Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Reixach, Natàlia (Scripps Research Institute) ; Insa, Raul (SOM-Biotech) ; Velazquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Reig, Núria (SOM-Biotech) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. [...]
2016 - 10.1038/ncomms10787
Nature communications, Vol. 7 (2016) , art. 10787  
Detailed record - Creative Commons
127.
12 p, 7.0 MB ATR is a multifunctional regulator of male mouse meiosis / Widger, Alexander (The Francis Crick Institute) ; Mahadevaiah, Shantha K. (Francis Crick Institute) ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Elinati, Elias (The Francis Crick Institute) ; Zohren, Jasmin (The Francis Crick Institute) ; Hirota, Takayuki (The Francis Crick Institute) ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Stanzione, Marcello (TU Dresden. Faculty of Medicine) ; Ojarikre, Obah (The Francis Crick Institute) ; Maciulyte, Valdone (The Francis Crick Institute) ; De Rooij, Dirk G.. (University of Amsterdam. Center for Reproductive Medicine) ; Tóth, Attila (TU Dresden. Faculty of Medicine) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Turner, James M. A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621  
Detailed record - Creative Commons
128.
16 p, 3.9 MB Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI) / Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bronsoms, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Covaleda Cortés, Giovanni (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Trejo, Sebastián A. (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Nerita Versicolor carboxypeptidase inhibitor (NvCI) is the strongest inhibitor reported so far for the M14A subfamily of carboxypeptidases. It comprises 53 residues and a protein fold composed of a two-stranded antiparallel β sheet connected by three loops and stabilized by three disulfide bridges. [...]
2017 - 10.1038/s41598-017-05657-7
Scientific reports, Vol. 7 (2017) , art. 5457  
Detailed record - Creative Commons
129.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo Ècija, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
Detailed record - Creative Commons
130.
13 p, 6.6 MB Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination / Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ; Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ; Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961  
Detailed record - Creative Commons
131.
16 p, 1.4 MB Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines / Huang, W. (North Carolina State University. Department of Biological Sciences) ; Massouras, A. (Ecole Polytechnique Fédérale de Lausanne. Institute of Bioengineering) ; Inoue, Y. (Osaka University. Center for Education in Liberal Arts and Sciences) ; Peiffer, J. (North Carolina State University. Department of Biological Sciences) ; Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tarone, A. M. (Texas AandM University. Department of Entomology) ; Turlapati, L. (North Carolina State University. Department of Biological Sciences) ; Zichner, T. (European Molecular Biology Laboratory) ; Zhu, Dianhui (Baylor College of Medicine. Human Genome Sequencing Center) ; Lyman, R. F. (North Carolina State University. Department of Biological Sciences) ; Magwire, M. M. (North Carolina State University. Department of Biological Sciences) ; Blankenburg, K. (Baylor College of Medicine. Human Genome Sequencing Center) ; Carbone, M. A. (North Carolina State University. Department of Biological Sciences) ; Chang, K. (Baylor College of Medicine. Human Genome Sequencing Center) ; Ellis, L. L. (Texas AandM University. Department of Entomology) ; Fernandez, S. (Baylor College of Medicine. Human Genome Sequencing Center) ; Han, Y. (Baylor College of Medicine. Human Genome Sequencing Center) ; Highnam, G. (Virginia Tech. Virginia Bioinformatics Institute) ; Hjelmen, C. E. (Texas AandM University. Department of Entomology) ; Jack, J. R. (North Carolina State University. Department of Biological Sciences) ; Javaid, M. (Baylor College of Medicine. Human Genome Sequencing Center) ; Jayaseelan, J. C (Baylor College of Medicine. Human Genome Sequencing Center) ; Kalra, D. (Baylor College of Medicine. Human Genome Sequencing Center) ; Lee, S. (Baylor College of Medicine. Human Genome Sequencing Center) ; Lewis, Lora (Baylor College of Medicine. Human Genome Sequencing Center) ; Munidasa, M. (Baylor College of Medicine. Human Genome Sequencing Center) ; Ongeri, F. (Baylor College of Medicine. Human Genome Sequencing Center) ; Patel, Shohba (Baylor College of Medicine. Human Genome Sequencing Center) ; Perales, L. (Baylor College of Medicine. Human Genome Sequencing Center) ; Perez, Agapito (Baylor College of Medicine. Human Genome Sequencing Center) ; Pu, L. L. (Baylor College of Medicine. Human Genome Sequencing Center) ; Rollmann, S. M. (North Carolina State University. Department of Biological Sciences) ; Ruth, R. (Baylor College of Medicine. Human Genome Sequencing Center) ; Saada, N. (Baylor College of Medicine. Human Genome Sequencing Center) ; Warner, C. (Shell International Exploration and Production, Inc.) ; Williams, A. (Baylor College of Medicine. Human Genome Sequencing Center) ; Wu, Y. Q. (Baylor College of Medicine. Human Genome Sequencing Center) ; Yamamoto, A. (North Carolina State University. Department of Biological Sciences) ; Zhang, Yiqing (Baylor College of Medicine. Human Genome Sequencing Center) ; Zhu, Y. (Baylor College of Medicine. Human Genome Sequencing Center) ; Anholt, Robert R. H (North Carolina State University. Department of Biological Sciences) ; Korbel, Jan O. (European Molecular Biology Laboratory) ; Mittelman, D. (Virginia Tech. Virginia Bioinformatics Institute. Department of Biological Sciences) ; Muzny, D. M. (Baylor College of Medicine. Human Genome Sequencing Centere) ; Gibbs, R. A. (Baylor College of Medicine. Human Genome Sequencing Center) ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Johnston, J. S. (Texas AandM University. Department of Entomology) ; Stone, E. A. (North Carolina State University. Department of Biological Sciences) ; Richards, S. (Baylor College of Medicine. Human Genome Sequencing Center) ; Deplancke, Bart (Swiss Institute of Bioinformatics) ; MacKay, T. F. C (North Carolina State University. Department of Biological Sciences)
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. [...]
2014 - 10.1101/gr.171546.113
Genome research, Vol. 24, issue 7 (July 2014) , p. 1193-1208  
Detailed record - Creative Commons
132.
20 p, 940.6 KB An enriched European eel transcriptome sheds light upon host-pathogen interactions with Vibrio vulnificus / Callol, Agnes (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Roig, Francisco J. (Universitat de València. Departament de Microbiologia i Ecologia) ; Goetz, Giles (Northwest Fisheries Science Center) ; Goetz, Frederick W. (Northwest Fisheries Science Center) ; Amaro, Carmen (Universitat de València. Departament de Microbiologia i Ecologia) ; Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Infectious diseases are one of the principal bottlenecks for the European eel recovery. The aim of this study was to develop a new molecular tool to be used in host-pathogen interaction experiments in the eel. [...]
2015 - 10.1371/journal.pone.0133328
PloS one, Vol. 10, issue 7 (2015) , art. e0133328  
Detailed record - Public domain
133.
19 p, 2.9 MB Transcriptome profiles associated to VHSV infection or DNA vaccination in turbot (Scophthalmus maximus) / Pereiro, Patricia (Instituto de Investigaciones Marinas (Vigo, Espanya)) ; Dios, Sonia (Instituto de Investigaciones Marinas (Vigo, Espanya)) ; Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Coll, Julio (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ; Estepa, Amparo (Universidad Miguel Hernández de Elche. Instituto de Biología Celular y Molecular) ; Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Novoa, Beatriz (Instituto de Investigaciones Marinas (Vigo, Espanya)) ; Figueras, Antonio (Instituto de Investigaciones Marinas (Vigo, Espanya))
DNA vaccines encoding the viral G glycoprotein show the most successful protection capability against fish rhabdoviruses. Nowadays, the molecular mechanisms underlying the protective response remain still poorly understood. [...]
2014 - 10.1371/journal.pone.0104509
PloS one, Vol. 9 issue 8 (2014) , art. e104509  
Detailed record - Creative Commons
134.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
Detailed record - Creative Commons
135.
5 p, 209.1 KB El colapso del pasado : COVID-19 / Giménez-Candela, Marita (Universitat Autònoma de Barcelona. ICALP (International Center for Animal Law and Policy))
Nos enfrentamos a una pandemia planetaria, cuyas consecuencias devastadoras han golpeado la vida de millones de seres humanos. El primer efecto que percibimos, de forma intuitiva, fue el colapso del pasado. [...]
We are faced with a global pandemic, the devastating consequences of which have struck the lives of millions of human beings. The first effect we intuitively sensed was the collapse of the past; a situation in which parallels with the scourges that past civilisations have experienced, as was the case in Rome, are clearly perceptible. [...]
2020 - 10.5565/rev/da.507
dA Derecho Animal : Forum of Animal Law Studies, Vol. 11 Núm. 2 (2020) , p. 7-16 (Editorial)  
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