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Articles 47 records found  previous11 - 20nextend  jump to record: Search took 0.01 seconds. 
11.
14 p, 2.1 MB The Footprint of Type 1 Diabetes on Red Blood Cells : A Metabolomic and Lipidomic Study / Herance, José Raul (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lamas-Domingo, Rubén (Centro de Investigación Príncipe Felipe (València)) ; Aparicio-Gómez, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Palomino-Schätzlein, Martina (Parque Tecnológico de Valencia) ; Universitat Autònoma de Barcelona
The prevalence of diabetes type 1 (T1D) in the world populations is continuously growing. Although treatment methods are improving, the diagnostic is still symptom-based and sometimes far after onset of the disease. [...]
2023 - 10.3390/jcm12020556
Journal of clinical medicine, Vol. 12 (january 2023)  
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12.
21 p, 1.4 MB The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics / Youssef, Lina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Crovetto, Francesca (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Simoes, Rui Vasco (Champalimaud Research. Champalimaud Centre for the Unknown) ; Miranda, Jezid (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Paules, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Blasco Pelicano, Miquel (Hospital Clínic i Provincial de Barcelona) ; Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García Calderó, Héctor (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Tura Ceide, Olga (Institut d'Investigació Biomèdica de Girona) ; Dantas, A. P (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Hernández-Gea, Virginia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Herrero, Pol (Eurecat. Centre Tecnològic de Catalunya) ; Canela, Núria (Eurecat. Centre Tecnològic de Catalunya) ; Campistol Plana, Josep M. (Hospital Clínic i Provincial de Barcelona) ; Garcia Pagan, Joan Carles (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gratacos, Eduard (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Introduction: Preeclampsia is a multi-system disorder unique to pregnancy responsible for a great part of maternal and perinatal morbidity and mortality. The precise pathogenesis of this complex disorder is still unrevealed. [...]
2022 - 10.3390/life12010086
Life, Vol. 12 Núm. 1 (january 2022) , p. 86  
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13.
18 p, 4.9 MB Understanding host-microbiota interactions in the commercial piglet around weaning / Saladrigas-García, Mireia (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; D'angelo, Matilde (Universitat Autònoma de Barcelona. Servei de Nutrició i Benestar Animal) ; Ko, Heng-Lun (Universitat Autònoma de Barcelona. Servei de Nutrició i Benestar Animal) ; Nolis Fañanas, Pau (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Folch, Josep M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Llonch, Pol (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Solà Oriol, David (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Pérez Hernández, José Francisco (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Martín Orúe, Susana M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Weaning is a critical period in the life of pigs with repercussions on their health and welfare and on the economy of the swine industry. This study aimed to assess the effect of the commercial early weaning on gut microbiota, intestinal gene expression and serum metabolomic response via an integrated-omic approach combining 16S rRNA gene sequencing, the OpenArray gene expression technology and 1 H-NMR spectroscopy. [...]
2021 - 10.1038/s41598-021-02754-6
Scientific reports, Vol. 11 (december 2021)  
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14.
22 p, 2.7 MB Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota / Barber, Claudia (Universitat Autònoma de Barcelona. Departament de Medicina) ; Sabater, Carlos (Health Research Institute of Asturias) ; Ávila-Gálvez, María Ángeles (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia)) ; Vallejo, Fernando (Metabolomics Service (Múrcia)) ; Bendezú García, Rogger Álvaro (Hospital General de Catalunya) ; Guérin-Deremaux, Laetitia (Roquette Frères) ; Guarner, Francisco (Hospital Universitari Vall d'Hebron) ; Espín, Juan Carlos (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia)) ; Margolles, Abelardo (Health Research Institute of Asturias) ; Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. [...]
2022 - 10.3390/nu14214611
Nutrients, Vol. 14 (november 2022)  
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15.
15 p, 2.1 MB Sex-specific metabolic pathways were associated with alzheimer's disease (Ad) endophenotypes in the european medical information framework for ad multimodal biomarker discovery cohort / Xu, J. (King's College London) ; Green, R. (King's College London) ; Kim, M. (Steno Diabetes Center) ; Lord, J. (King's College London) ; Ebshiana, A. (King's College London) ; Westwood, S. (Department of Psychiatry. University of Oxford) ; Baird, Alison L (Department of Psychiatry. University of Oxford) ; Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford) ; Shi, L. (Department of Psychiatry. University of Oxford) ; Hye, Abdul (King's College London) ; Snowden, S. G. (King's College London) ; Bos, Isabelle (Amsterdam UMC. University Medical Center) ; Vos, S. J. B. (Maastricht University) ; Vandenberghe, R. (Alzheimer Center. VU University Medical Center) ; Teunissen, C. E. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ; Kate, M. T. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ; Scheltens, P. (Alzheimer Center. VU University Medical Center) ; Gabel, Silvy (University Hospitals Leuven (Bèlgica)) ; Meersmans, K. (University Hospitals Leuven (Bèlgica)) ; Blin, Olivier (Clinical Pharmacology & Pharmacovigilance Department. Aix-Marseille University-CNRS) ; Richardson, J. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ; De Roeck, Ellen E (University of Antwerp. Institute Born-Bunge) ; Engelborghs, Sebastiaan (RUniversity of Antwerp. Institute Born-Bunge) ; Sleegers, Kristel (Complex Genetics of Alzheimer's Disease Group. VIB Center for Molecular Neurology. VIB) ; Bordet, Régis (Université de Lille. Department of Medical Pharmacology) ; Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kettunen, Petronella (University of Gothenburg) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, F. R. J. (Maastricht University. Alzheimer Centrum Limburg) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Tainta, Mikel (Fundación CITA-Alzhéimer Fundazioa) ; Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet) ; Freund-Levi, Yvonne (King's College London) ; Frölich, L. (University of Heidelberg. Department of Geriatric Psychiatry) ; Dobricic, Valerija (University of Lübeck. Institutes of Neurogenetics and Cardiogenetics) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Wallin, Anders (University of Gothenburg. Sahlgrenska Academy) ; Popp, J. (University Hospital of Psychiatry Zürich) ; Martinez-Lage, P. (Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Bertram, Lars (University of Oslo. Department of Psychology) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Streffer, J. (Reference Center for Biological Markers of Dementia (BIODEM). Institute Born-Bunge. University of Antwerp) ; Jelle Visser, P. (Maastricht University. Alzheimer Centrum Limburg) ; Lovestone, Simon (Janssen-Cilag UK Ltd.) ; Proitsi, P. (King's College London) ; Legido-Quigley, Cristina (Steno Diabetes Center) ; Universitat Autònoma de Barcelona
Background: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. [...]
2021 - 10.3390/biomedicines9111610
Biomedicines, Vol. 9 Núm. 11 (november 2021) , p. 1610  
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16.
31 p, 3.7 MB Metabolomics for personalized medicine : the input of analytical chemistry from biomarker discovery to point-of-care tests / Castelli, Florence Anne (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ; Rosati, Giulio (Institut Català de Nanociència i Nanotecnologia) ; Moguet, Christian (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ; Fuentes-Chust, Celia (Institut Català de Nanociència i Nanotecnologia) ; Marrugo-Ramirez, Jose (Institut Català de Nanociència i Nanotecnologia) ; Lefebvre, Thibaud (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ; Volland, Hervé (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ; Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia) ; Simon, Stéphanie (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ; Fenaille, François (MetaboHUB (France)) ; Junot, Christophe (MetaboHUB (France))
Metabolomics refers to the large-scale detection, quantification, and analysis of small molecules (metabolites) in biological media. Although metabolomics, alone or combined with other omics data, has already demonstrated its relevance for patient stratification in the frame of research projects and clinical studies, much remains to be done to move this approach to the clinical practice. [...]
2022 - 10.1007/s00216-021-03586-z
Analytical and bioanalytical chemistry, Vol. 414, Issue 2 (January 2022) , p. 759-789  
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17.
23 p, 1.8 MB Establishing Imaging Biomarkers of Host Immune System Efficacy during Glioblastoma Therapy Response : challenges, Obstacles and Future Perspectives / Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona) ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona)
This hypothesis proposal addresses three major questions: (1) Why do we need imaging biomarkers for assessing the efficacy of immune system participation in glioblastoma therapy response? (2) Why are they not available yet? and (3) How can we produce them? We summarize the literature data supporting the claim that the immune system is behind the efficacy of most successful glioblastoma therapies but, unfortunately, there are no current short-term imaging biomarkers of its activity. [...]
2022 - 10.3390/metabo12030243
Metabolites, Vol. 12 Núm. 3 (2022) , p. 243  
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18.
11 p, 1.7 MB Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children / Comella-del-Barrio, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Izquierdo-Garcia, José Luis (Basque Research and Technology Alliance) ; Gautier, Jacqueline (Hôpital Saint-Damien (Haití)) ; Doresca, Mariette Jean Coute (Hôpital Saint-Damien (Haití)) ; Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas (Madrid)) ; Santiveri, Clara M. (Centro Nacional de Investigaciones Oncológicas (Madrid)) ; Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Prat i Aymerich, Cristina (University Medical Center Utrecht) ; Abellana, Rosa (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ; Pérez-Porcuna, Tomás M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Cuevas, Luis E.. (Liverpool School of Tropical Medicine. Department of Clinical Sciences) ; Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ; Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. [...]
2021 - 10.1038/s41598-021-91545-0
Scientific reports, Vol. 11 (june 2021)  
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19.
14 p, 2.4 MB Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients / Marin-Corral, Judith (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rodríguez-Morató, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ; Gomez-Gomez, A (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pascual-Guardia, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Muñoz-Bermúdez, Rosana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Salazar-Degracia, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pérez-Terán, Purificación (Institut Hospital del Mar d'Investigacions Mèdiques) ; Restrepo, Marcos I. (South Texas Veterans Health Care System) ; Khymenets, Olha (Institut Hospital del Mar d'Investigacions Mèdiques) ; Haro, Noemí (Institut Hospital del Mar d'Investigacions Mèdiques) ; Masclans, Joan R. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. [...]
2021 - 10.3390/ijms22094794
International journal of molecular sciences, Vol. 22 (april 2021)  
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20.
18 p, 5.1 MB Highly Species-Specific Foliar Metabolomes of Diverse Woody Species and Relationships with the Leaf Economics Spectrum / Schweiger, Rabea (Bielefeld University. Department of Chemical Ecology) ; Castells, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Da Sois, Luca (Centre de Recerca Ecològica i d'Aplicacions Forestals) ; Martínez Vilalta, Jordi 1975- (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Müller, Caroline (Bielefeld University. Department of Chemical Ecology)
Plants show an extraordinary diversity in chemical composition and are characterized by different functional traits. However, relationships between the foliar primary and specialized metabolism in terms of metabolite numbers and composition as well as links with the leaf economics spectrum have rarely been explored. [...]
2021 - 10.3390/cells10030644
Cells, Vol. 10, Issue 3 (March 2021) , art. 644  
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