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1.
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15 p, 5.4 MB |
Nerve Fiber Immunohistochemical Panel Discriminates between Nerve Sheath and Perivascular Wall Tumors
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Sisó, Sílvia (AbbVie. Pathology, Immunology Discovery) ;
Marco-Salazar, Paola (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Roccabianca, Paola (University of Milan. Department of Veterinary Medicine and Animal Sciences) ;
Avallone, Giancarlo (University of Bologna. Department of Veterinary Medical Sciences) ;
Higgins, Robert J. (University of California Davis. Departments of Pathology, Microbiology and Immunology) ;
Affolter, Verena K. (University of California Davis. Departments of Pathology, Microbiology and Immunology)
Soft-tissue sarcomas are classified as nerve sheath tumors if originating within nerves. However, tumors of the nerves still pose a frequent challenge for diagnostic veterinary pathologists since identifying nerve histomorphology based only on the examination of hematoxylin-and-eosin-stained sections is often insufficient. [...]
2022 -  10.3390/vetsci10010001
Veterinary Sciences, Vol. 10 (december 2022)
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2.
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3.
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19 p, 9.6 MB |
Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation
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Gámez-Chiachio, Manuel (Centro de Investigación Biomédica en Red de Cáncer) ;
Molina-Crespo, Ángela (Universidad Autónoma de Madrid (UAM) Instituto de Investigaciones Biomédicas 'Alberto Sols') ;
Ramos-Nebot, Carmen (Centro de Investigación Biomédica en Red de Cáncer) ;
Martinez-Val, Jeannette (Universidade de Santiago de Compostela) ;
Martinez, Lidia (Universidad Autónoma de Madrid) ;
Gassner, Katja (Mecanismos Moleculares Y Terapia Experimental en Oncologia-Programa OncobellIdibell (L'Hospitalet de Llobregat)) ;
Llobet, Francisco J. (Mecanismos Moleculares Y Terapia Experimental en Oncologia-Programa OncobellIdibell (L'Hospitalet de Llobregat)) ;
Soriano, Mario (Centro de Investigación Príncipe Felipe (València)) ;
Hernandez, Alberto (Centro de Investigación Príncipe Felipe (València)) ;
Cordani, Marco (Universidad Autónoma de Madrid) ;
Bernadó Morales, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Diaz, Eva (Fundación MD Anderson Internacional (Madrid)) ;
Rojo-Sebastian, Alejandro (Fundación MD Anderson Internacional (Madrid)) ;
Triviño, Juan Carlos (Sistemas Genómicos) ;
Sánchez-García, Laura (Mecanismos Moleculares Y Terapia Experimental en Oncologia-Programa OncobellIdibell (L'Hospitalet de Llobregat)) ;
Rodríguez-Barrueco, Ruth (Unidad de Anatomia Universidad de Barcelona) ;
Arribas, Joaquín V (Vall d'Hebron Institut d'Oncologia) ;
Llobet-Navás, David (Mecanismos Moleculares Y Terapia Experimental en Oncologia-Programa OncobellIdibell (L'Hospitalet de Llobregat)) ;
Sarrió, David (Centro de Investigación Biomédica en Red de Cáncer) ;
Moreno-Bueno, Gema (Fundación MD Anderson Internacional (Madrid)) ;
Universitat Autònoma de Barcelona
Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance is crucial to identify novel effective targeted treatments for HER2/GSDMB aggressive tumors. [...]
2022 - 10.1186/s13046-022-02497-w
Journal of Experimental & Clinical Cancer Research : CR, Vol. 41 (september 2022)
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4.
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17 p, 24.9 MB |
Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Martínez, Araceli (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Rodríguez-Lloveras, Helena (Institut Germans Trias i Pujol) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe de València) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Simó-Servat, Andreu (Mútua de Terrassa) ;
Webb, S. M.. 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Picó, Antonio (Universidad de Miguel Hernández de Elche) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. [...]
2022 - 10.3390/biomedicines10020460
Biomedicines, Vol. 10 (february 2022)
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5.
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20 p, 1.9 MB |
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types
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Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez, Maica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Romeo, Margarita (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Morán, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Layos, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez-Roca, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Pedro Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ample evidence exists connecting dNTP pool dysregulation to cancer and genomic instability. SAMHD1, the unique dNTP triphosphohydrolase described in humans, has been proposed to play a key role in hematological cancers, although its value in advanced solid tumors has not yet been explored. [...]
2022 - 10.3390/cancers14030641
Cancers, Vol. 14 Núm. 3 (january 2022)
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6.
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17 p, 3.9 MB |
CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models
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Antonelli, Roberta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riley, Misha (Massachusetts General Hospital (Boston)) ;
Servidei, Tiziana (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Riccardi, Riccardo (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martini, Maurizio (Catholic University of Sacred Heart) ;
Ruggiero, Antonio (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Moreno, Lucas (Vall d'Hebron Institut d'Oncologia) ;
Sánchez de Toledo Codin, Josep (Vall d'Hebron Institut d'Oncologia) ;
Gallego, Soledad (Vall d'Hebron Institut d'Oncologia) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hooker, Jacob M. (Massachusetts General Hospital (Boston)) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of cases develop in the posterior fossa and can be classified into two distinct molecular entities: EPN posterior fossa A (PF-EPN-A) and EPN posterior fossa B (PF-EPN-B). [...]
2020 - 10.3390/cancers12071922
Cancers, Vol. 12 (july 2020)
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7.
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13 p, 11.2 MB |
Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor - an update on neuroendocrine neoplasm's treatment : A case report
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Mirallas, Oriol (Vall d'Hebron Institut d'Oncologia) ;
Saoudi, Nadia (Vall d'Hebron Institut d'Oncologia) ;
Gomez-Puerto, Diego (Vall d'Hebron Institut d'Oncologia) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Merino, Xavier (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Blanco, Laia (Hospital Universitari Vall d'Hebron) ;
Garcia-Burillo, Amparo (Hospital Universitari Vall d'Hebron) ;
Molero, Xavier (Hospital Universitari Vall d'Hebron) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ;
Capdevila Castillón, Jaume (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Metastatic small bowel low-grade neuroendocrine tumors (NETs) have a good prognosis. Surgery is the only curative treatment; however, this may induce advanced liver disease, particularly in long-term survivor patients. [...]
2021 - 10.4254/wjh.v13.i5.611
World Journal of Hepatology, Vol. 13 (may 2021) , p. 611-619
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8.
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6 p, 2.1 MB |
MR imaging findings in primary spinal cord glioblastoma
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Ferrante, Paolo (Hospital Universitari Vall d'Hebron) ;
Mora, Juan Andres (Fundación Universitaria Sanitas, Clinica Reina Sofia) ;
Salazar, Lourdes (Hospital Universitari Vall d'Hebron) ;
Sáez, Elena Martínez (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Spinal cord glioblastoma is a rare disease, with an aggressive course and a poor prognosis. We describe magnetic resonance imaging (MRI) findings, in 3 adult cases of biopsy-confirmed glioblastoma. Conventional MRI findings were unclear with regard to the differential diagnosis between this rare tumor and other more common spinal cord lesions, including less aggressive tumors such as ependymoma or pilocytic astrocytoma, abscesses or tumefactive demyelinating lesions. [...]
2020 - 10.1016/j.radcr.2020.10.043
Radiology Case Reports, Vol. 16 (november 2020) , p. 72-77
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9.
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7 p, 314.9 KB |
Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly
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Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Soldevila, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. [...]
2021 - 10.3389/fendo.2021.646210
Frontiers in Endocrinology, Vol. 12 (march 2021)
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10.
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11 p, 2.6 MB |
Development of adaptive immune effector therapies in solid tumors
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Comoli, P. (Cell Factory and Pediatric Hematology Oncology. Fondazione IRCCS Policlinico San Matteo) ;
Chabannon, C. (Institut Paoli-Calmettes. Aix-Marseille University. INSERM CBT 1409. Centre for Clinical Investigation in Biotherapy) ;
Koehl, U. (Institute of Cellular Therapeutics. Hannover Medical School) ;
Lanza, F. (Hematology and Stem Cell Transplant. Romagna Transplant Network) ;
Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Hudecek, M. (University Hospital Würzburg) ;
Ruggeri, A. (Ospedale Pediatrico Bambino Gesù (Roma, Itàlia)) ;
Secondino, S. (Università degli Studi di Pavia. Dipartimento di Medicina Interna e Terapia Medica) ;
Bonini, C. (University Vita-Salute San Raffaele) ;
Pedrazzoli, P. (Università degli Studi di Pavia. Dipartimento di Medicina Interna e Terapia Medica) ;
Universitat Autònoma de Barcelona
State-of-the-art treatment strategies have drastically ameliorated the outcome of patients affected by cancer. However, resistant and recurrent solid tumors are generally nonresponsive to conventional therapies. [...]
2019 - 10.1093/annonc/mdz285
Annals of oncology, Vol. 30 Núm. 11 (november 2019) , p. 1740-1750
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