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11.
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20 p, 4.0 MB |
Hepatic Oxi-Inflammation and Neophobia as Potential Liver-Brain Axis Targets for Alzheimer's Disease and Aging, with Strong Sensitivity to Sex, Isolation, and Obesity
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Fraile-Ramos, Juan (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Garrit, Anna (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Reig-Vilallonga, Josep (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Research on Alzheimer's disease (AD) has classically focused on alterations that occur in the brain and their intra- and extracellular neuropathological hallmarks. However, the oxiinflammation hypothesis of aging may also play a role in neuroimmunoendocrine dysregulation and the disease's pathophysiology, where the liver emerges as a target organ due to its implication in regulating metabolism and supporting the immune system. [...]
2023 -  10.3390/cells12111517
Cells, Vol. 12 (may 2023)
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12.
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16 p, 1.4 MB |
Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells
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Lehmann, Guillermo L. (Regeneron Pharmaceuticals. Inc.) ;
Ginsberg, Michael (Angiocrine Bioscience. Inc.) ;
Nolan, Daniel J. (Angiocrine Bioscience. Inc.) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Zeng, Shemin (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Voigt, Andrew P. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Mullins, Robert F. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Rafii, Shahin (Ansary Stem Cell Institute. Department of Medicine. Division of Regenerative Medicine. Weill Cornell Medicine) ;
Rodriguez-Boulan, Enrique (Margaret Dyson Vision Research Institute. Department of Ophthalmology. Weill Cornell Medicine) ;
Benedicto, Ignacio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. [...]
2022 - 10.3390/cells11192975
Cells, Vol. 11 Núm. 19 (october 2022) , p. 2975
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13.
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16 p, 3.3 MB |
Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn's Disease Patients through Epigenetic Changes
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Boronat-Toscano, Albert (Hospital Universitari Joan XXIII de Tarragona) ;
Vañó, Irene (Institut d'Investigació Sanitària Pere Virgili) ;
Monfort-Ferré, Diandra (Hospital Universitari Joan XXIII de Tarragona) ;
Menacho, Margarita (Hospital Universitari Joan XXIII de Tarragona) ;
Valldosera, Gemma (Hospital Universitari Joan XXIII de Tarragona) ;
Caro, Aleidis (Hospital Universitari Joan XXIII de Tarragona) ;
Espina, Beatriz (Hospital Universitari Joan XXIII de Tarragona) ;
Mañas, Maria José (Hospital Sant Pau i Santa Tecla (Tarragona)) ;
Marti-Gallostra, Marc (Hospital Universitari Vall d'Hebron) ;
Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron) ;
Saera-Vila, Alfonso (Sequentia Biotech) ;
Serena, Carolina (Institut d'Investigació Sanitària Pere Virgili) ;
Universitat Autònoma de Barcelona
Patients with Crohn's disease (CD) who smoke are known to have a worse prognosis than never-smokers and a higher risk for post-surgical recurrence, whereas patients who quit smoking after surgery have significantly lower post-operative recurrence. [...]
2023 - 10.3390/cells12071021
Cells, Vol. 12 (march 2023)
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14.
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15.
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13 p, 1.5 MB |
Immunomodulatory Effects Associated with Cladribine Treatment
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Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Boschert, Ursula (Merck KGaA, 64297 Darmstadt, Germany) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Cladribine is a synthetic deoxyadenosine analogue with demonstrated efficacy in patients with relapsing-remitting multiple sclerosis (MS). The main mechanism of action described for cladribine is the induction of a cytotoxic effect on lymphocytes, leading to a long-term depletion of peripheral T and B cells. [...]
2021 - 10.3390/cells10123488
Cells, Vol. 10 (december 2021) , art. 3488
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16.
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17 p, 2.5 MB |
Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa : Implications for Irritable Bowel Syndrome
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Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salvo-Romero, Eloísa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galan Soldevilla, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Torres, Inés (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pribic, Teodora (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo Álvarez, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallart, Milagros (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pardo-Camacho, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guagnozzi, Danila (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Santos, Javier (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Alonso Cotoner, Carmen (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder linked to intestinal barrier dysfunction and life stress. We have previously reported that female sex per se determines an increased susceptibility to intestinal barrier dysfunction after cold pain stress (CPS). [...]
2023 - 10.3390/cells12030423
Cells, Vol. 12 (january 2023)
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17.
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28 p, 5.6 MB |
The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina
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Sirés, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pazo-González, Mateo (Universidad de Alcalá) ;
López-Soriano, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Méndez, Ana (Institut d'Investigació Biomèdica de Bellvitge) ;
de la Rosa, Enrique J. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
de la Villa, Pedro (Universidad de Alcalá) ;
Comella i Carnicé, Joan Xavier 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-Sánchez, Catalina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described that Faim knockout (KO) mice present structural and molecular alterations in the retina compatible with a neurodegenerative phenotype. [...]
2023 - 10.3390/cells12030487
Cells, Vol. 12 (february 2023)
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18.
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18 p, 1.7 MB |
The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons
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Rivas-Santisteban, Rafael (Universitat de Barcelona. Institut de Neurociències) ;
Raïch, Iu (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Franco, Rafael (Universitat de Barcelona. Facultat de Química) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia)
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer's disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. [...]
2023 - 10.3390/cells12020283
Cells, Vol. 12 (january 2023)
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19.
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21 p, 985.0 KB |
Role of Moonlighting Proteins in Disease : Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
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Huerta Casado, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The term moonlighting proteins refers to those proteins that present alternative functions performed by a single polypeptide chain acquired throughout evolution (called canonical and moonlighting, respectively). [...]
2023 - 10.3390/cells12020235
Cells, Vol. 12, Issue 2 (January 2023) , art. 235
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20.
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8 p, 936.1 KB |
Concomitant Hereditary Spherocytosis and Pyruvate Kinase Deficiency in a Spanish Family with Chronic Hemolytic Anemia : Contribution of Laser Ektacytometry to Clinical Diagnosis
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Vives Corrons, Juan Luís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Krishnevskaya, Elena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Montllor, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Leguizamon, Valentina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia Bernal, Marta (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Universitat Autònoma de Barcelona
Background: Hereditary spherocytosis (HS) and pyruvate kinase deficiency (PKD) are the most common causes of hereditary chronic hemolytic anemia. Here, we describe clinical and genetic characteristics of a Spanish family with concomitant β-spectrin (SPTB) c. [...]
2022 - 10.3390/cells11071133
Cells, Vol. 11 Núm. 7 (4-1 2022) , art. 1133
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