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13 p, 1.5 MB |
Immunomodulatory Effects Associated with Cladribine Treatment
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Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Boschert, Ursula (Merck KGaA, 64297 Darmstadt, Germany) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Cladribine is a synthetic deoxyadenosine analogue with demonstrated efficacy in patients with relapsing-remitting multiple sclerosis (MS). The main mechanism of action described for cladribine is the induction of a cytotoxic effect on lymphocytes, leading to a long-term depletion of peripheral T and B cells. [...]
2021 -  10.3390/cells10123488
Cells, Vol. 10 (december 2021) , art. 3488
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17 p, 1.8 MB |
Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis
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Edo Salvador, Ángel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The pathogenic role of the interleukin 21 (IL-21) in diferent autoimmune diseases, such as multiple sclerosis (MS), has been extensively studied. However, its pleiotropic nature makes it a cytokine that may exhibit diferent activity depending on the immunological stage of the disease. [...]
2022 - 10.1007/s13311-022-01279-8
Neurotherapeutics, Vol. 19 (july 2022) , p. 1617-1633
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66 p, 702.7 KB |
The New Fairy Tale : Subverting Genre and Characterization in Diana Wynne-Jones Howl's Moving Castle and its Film Adaptation
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Espejo Navas, Cristina ;
Martín Alegre, Sara, dir. ;
Universitat Autònoma de Barcelona.
Facultat de Filosofia i Lletres ;
Universitat Autònoma de Barcelona.
Filologia Anglesa i de Germanística
This dissertation explores how Jones and Miyazaki subvert the fairy tale tradition in their stories. To do this, it will analyse the development of the novel's main characters, Sophie and Howl, and then explore the relationship between the novel and its homonymous animated adaptation, directed by Miyazaki in 2004. [...]
Aquesta dissertació explora com Jones i Miyazaki subverteixen la tradició del conte de fades en les seves històries. Per aquest fi, analitza el desenvolupament dels personatges principals de la novel·la, la Sophie y en Howl, i explora la relació entre la novel·la i la seva adaptació animada homònima, dirigida per Miyazaki i estrenada al 2004. [...]
Esta disertación explora cómo Jones y Miyazaki subvierten la tradición del cuento de hadas en sus historias. Para ello, analiza el desarrollo de los personajes principales de la novela, Sophie y Howl, y explora la relación entre la novela y su adaptación animada homónima, dirigida por Miyazaki y estrenada en 2004. [...]
2021
Màster Universitari en Estudis Anglesos Avançats / Advanced English Studies [1099]
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8 p, 441.0 KB |
Serum Biomarker gMS-Classifier2 : Predicting Conversion to Clinically Definite Multiple Sclerosis
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron) ;
Yarden, Jennifer (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Fire, Ella (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Spector, Larissa (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Dotan, Nir (Department of Research and Development, Glycominds, Modi'in, Israel) ;
Dukler, Avinoam (Department of Research and Development, Glycominds, Simi Valley, California, United States of America) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Anti-glycan antibodies can be found in autoimmune diseases. IgM against glycan P63 was identified in clinically isolated syndromes (CIS) and included in gMS-Classifier2, an algorithm designed with the aim of identifying patients at risk of a second demyelinating attack. [...]
2013 - 10.1371/journal.pone.0059953
PloS one, Vol. 8 (march 2013)
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12 p, 13.6 MB |
Hsp70 Regulates Immune Response in Experimental Autoimmune Encephalomyelitis
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Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona) ;
Costa, Carme (Universitat Autònoma de Barcelona) ;
Eixarch, Herena (Universitat Autònoma de Barcelona) ;
Tepavcevic, Vanja (Sorbonne Universités) ;
Castillo, Mireia (Universitat Autònoma de Barcelona) ;
Martin, Roland (University Hospital Zurich (Suïssa)) ;
Lubetzki, Catherine (Sorbonne Universités) ;
Aigrot, Marie-Stéphane (Sorbonne Universités) ;
Montalban, Xavier (Universitat Autònoma de Barcelona) ;
Espejo, Carmen (Universitat Autònoma de Barcelona)
Heat shock protein (Hsp)70 is one of the most important stress-inducible proteins. Intracellular Hsp70 not only mediates chaperone-cytoprotective functions but can also block multiple steps in the apoptosis pathway. [...]
2014 - 10.1371/journal.pone.0105737
PloS one, Vol. 9 (august 2014)
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11 p, 2.5 MB |
Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE
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Marín, Nieves (Red Española de Esclerosis Múltiple) ;
Mecha, Miriam (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Espejo, Carmen (Universitat Autònoma de Barcelona) ;
Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Eixarch, Herena (Universitat Autònoma de Barcelona) ;
Montalban, Xavier (Universitat Autònoma de Barcelona) ;
Alvarez-Cermeño, José C (Universidad de Alcalá) ;
Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Villar, Luisa M. (Red Española de Esclerosis Múltiple)
Background and Objectives. Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. [...]
2014 - 10.1155/2014/156380
Journal of Immunology Research, Vol. 2014 (april 2014)
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16 p, 2.6 MB |
Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus
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Carrillo-Salinas, Francisco J (Red Española de Esclerosis Múltiple) ;
Mestre, L. (Red Española de Esclerosis Múltiple) ;
Mecha, Miriam (Red Española de Esclerosis Múltiple) ;
Feliú, Ana (Red Española de Esclerosis Múltiple) ;
del Campo, Rosa (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Villarrubia, Noelia (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Universidad de Alcalá) ;
Villar, L. M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Guaza, C. (Red Española de Esclerosis Múltiple) ;
Universitat Autònoma de Barcelona
Recent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. [...]
2017 - 10.1038/srep44377
Scientific reports, Vol. 7 (03 2017)
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22 p, 4.1 MB |
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis
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Calvo-Barreiro, Laura (Universitat Autònoma de Barcelona) ;
Eixarch, Herena (Universitat Autònoma de Barcelona) ;
Ponce-Alonso, Manuel (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Castillo, Mireia (Universitat Autònoma de Barcelona) ;
Lebrón-Galán, Rafael (Hospital Nacional de Parapléjicos (Toledo)) ;
Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Clemente, Diego (Grupo de Neuroinmuno-Reparación, Unidad de Investigación, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, 45071 Toledo, Spain) ;
del Campo, Rosa (Hospital Universitario Ramón y Cajal (Madrid)) ;
Montalban, Xavier (Universitat Autònoma de Barcelona) ;
Espejo, Carmen (Universitat Autònoma de Barcelona) ;
Instituto Cajal (Madrid)
Previous studies in experimental autoimmune encephalomyelitis (EAE) models have shown that some probiotic bacteria beneficially impact the development of this experimental disease. Here, we tested the therapeutic effect of two commercial multispecies probiotics-Lactibiane iki and Vivomixx-on the clinical outcome of established EAE. [...]
2020 - 10.3390/cells9040906
Cells, Vol. 9 (april 2020)
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11 p, 5.6 MB |
New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab
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Toboso, Inmaculada (Hospital Universitario Ramón y Cajal (Madrid)) ;
Tejeda-Velarde, Amalia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Lafuente, Roberto (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Arroyo, Rafael (Hospital Universitario Quiron Salud) ;
Hegen, Harald (Medical University of Innsbruck) ;
Deisenhammer, Florian (Medical University of Innsbruck) ;
Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Cermeño, José C. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Paramo, Dolores (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Oliva, Pedro (Hospital Universitario Central de Asturias) ;
Casanova, Bonaventura (Hospital Universitari i Politècnic La Fe (València)) ;
Agüera-Morales, Eduardo (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Franciotta, Diego (Istituti di Recovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation) ;
Gastaldi, Matteo (Istituti di Recovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation) ;
Fernández, Oscar (Hospital Regional Universitario de Málaga) ;
Urbaneja, Patricia (Hospital Regional Universitario de Málaga) ;
Garcia-Dominguez, José M. (Hospital General Universitario Gregorio Marañón) ;
Romero, Fernando (Hospital General Universitario Gregorio Marañón) ;
Laroni, Alicia (University of Genoa, Ospedale Policlinico San Martino) ;
Uccelli, Antonio (University of Genoa, Ospedale Policlinico San Martino) ;
Perez-Sempere, Angel (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Blanco, Yolanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Galimberti, Daniela (University of Milan) ;
Scarpini, Elio (University of Milan) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rasche, Ludwig (Humboldt-Universität zu Berlin) ;
Paul, Friedemann (Charité - Universitätsmedizin Berlin) ;
González, Inés (Hospital Álvaro Cunqueiro (Vigo)) ;
Álvarez, Elena (Hospital Álvaro Cunqueiro (Vigo)) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Caminero, Ana B. (Hospital Nuestra Señora de Sonsoles (Àvila)) ;
Aladro, Yolanda (Hospital Universitario Getafe) ;
Calles, Carmen (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Eguía, Pablo (Hospital Doctor Jose Molina Orosa) ;
Belenguer-Benavides, Antonio (Consorci Hospitalari Provincial de Castelló) ;
Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta) ;
Quintana, Ester (Hospital Universitari de Girona Doctor Josep Trueta) ;
Martínez-Rodríguez, José E. (Hospital del Mar (Barcelona, Catalunya)) ;
Oterino, Agustín (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
López de Silanes, Carlos (Hospital Universitario de Torrejón) ;
Casanova, Luis I. (Hospital Universitario de Torrejón) ;
Landete Pascual, Lamberto (Hospital Universitari Doctor Peset (València)) ;
Frederiksen, Jette (Glostrup University Hospital Copenhagen) ;
Bsteh, Gabriel (Medical University of Innsbruck) ;
Mulero, P. (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Hernández, Miguel A. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Espiño, Mercedes (Hospital Universitario Ramón y Cajal (Madrid)) ;
Prieto, José M. (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Pérez, Domingo (Hospital del Bierzo (Ponferrada, Lleó)) ;
Otano, María (Complejo Hospitalario de Navarra) ;
Padilla, Francisco (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
García-Merino, Juan A. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Navarro Cantó, Laura (Hospital General Universitario de Elche) ;
Muriel, Alfonso (Hospital Universitario Ramón y Cajal (Madrid)) ;
Frossard, Lucienne Costa (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona
Overview: We assessed the role of age and disease activity as new factors contributing to establish the risk of progressive multifocal leucoencephalopathy in multiple sclerosis patients treated with natalizumab in 36 University Hospitals in Europe. [...]
2020 - 10.3389/fneur.2020.579438
Frontiers in neurology, Vol. 11 (december 2020)
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