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1.
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9 p, 3.8 MB |
Correlative radioimaging and mass spectrometry imaging : a powerful combination to study 14C-graphene oxide in vivo biodistribution
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Cazier, Hélène (Université Paris Saclay) ;
Malgorn, Carole (Université Paris Saclay) ;
Georgin, Dominique (Université Paris Saclay) ;
Fresneau, Nathalie (Université Paris Saclay) ;
Beau, Fabrice (Université Paris Saclay) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester) ;
Campidelli, Stéphane (Université Paris Saclay) ;
Pinault, Mathieu (Université Paris-Saclay) ;
Mayne-L'Hermite, Martine (Université Paris-Saclay) ;
Taran, Frédéric (Université Paris Saclay) ;
Junot, Christophe (Université Paris Saclay) ;
Fenaille, François (Université Paris Saclay) ;
Sallustrau, Antoine (Université Paris Saclay) ;
Colsch, Benoit (Université Paris Saclay)
Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the development of more efficient imaging techniques to track the fate of these materials. [...]
2023 -  10.1039/d2nr06753f
Nanoscale, Vol. 15, Issue 11 (March 2023) , p. 5510-5518
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2.
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17 p, 11.3 MB |
Lung Persistence, Biodegradation, and Elimination of Graphene-Based Materials are Predominantly Size-Dependent and Mediated by Alveolar Phagocytes
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Loret, Thomas (University of Manchester. Nanomedicine Lab) ;
De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre) ;
Lucherelli, Matteo Andrea (University of Strasbourg) ;
Fordham, Alexander (University of Manchester. Nanomedicine Lab) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Bianco, Alberto (University of Strasbourg) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab)
Graphene-based materials (GBMs) have promising applications in various sectors, including pulmonary nanomedicine. Nevertheless, the influence of GBM physicochemical characteristics on their fate and impact in lung has not been thoroughly addressed. [...]
2023 - 10.1002/smll.202301201
Small, Vol. 19, Issue 39 (September 2023) , art. 2301201
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3.
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21 p, 2.7 MB |
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile
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De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre) ;
Loret, Thomas (University of Manchester. Nanomedicine Lab) ;
Fordham, Alexander (University of Manchester. Nanomedicine Lab) ;
Arshad, Atta (University of Manchester. Nanomedicine Lab) ;
Drummond, Matthew (University of Manchester. National Graphene Institute) ;
Dodd, Abbie (University of Manchester. National Graphene Institute) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab)
A key aspect of any new material safety assessment is the evaluation of their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about its safety profile, especially after inhalation. [...]
2022 - 10.1186/s12989-022-00502-w
Particle and fibre toxicology, Vol. 19 (September 2022) , art. 62
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4.
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25 p, 12.3 MB |
Hazard assessment of abraded thermoplastic composites reinforced with reduced graphene oxide
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Chortarea, Savvina (Swiss Federal Laboratories for Materials Science and Technology) ;
Kuru, Ogul Can (Swiss Federal Laboratories for Materials Science and Technology) ;
Netkueakul, Woranan (Swiss Federal Laboratories for Materials Science and Technology) ;
Pelin, Marco (Università degli Studi di Trieste. Dipartimento di Scienze della Vita) ;
Keshavan, Sandeep (Karolinska Institutet (Estocolm, Suècia). Nanosafety & Nanomedicine Laboratory) ;
Song, Zhengmei (Centre national de la recherche scientifique. Institut de Biologie Moléculaire et Cellulaire) ;
Ma, Baojin (Centre national de la recherche scientifique. Institut de Biologie Moléculaire et Cellulaire) ;
Gómes, Julio (Avanzare Innovacion Tecnologica S.L) ;
Villaro Abalos, Elvira (InterQuímica) ;
Visani de Luna, Luis Augusto (University of Manchester. Nanomedicine Lab) ;
Loret, Thomas (University of Manchester. Nanomedicine Lab) ;
Fordham, Alexander (University of Manchester. Nanomedicine Lab) ;
Drummond, Matthew (University of Manchester. National Graphene Institute) ;
Kontis, Nikolaos (Foundation of Research and Technology-Hellas) ;
Anagnostopoulos, George (Foundation of Research and Technology-Hellas) ;
Paterakis, George (Foundation of Research and Technology-Hellas) ;
Cataldi, Pietro (University of Manchester. Department of Materials) ;
Tubaro, Aurelia (Università degli Studi di Trieste. Dipartimento di Scienze della Vita) ;
Galiotis, Costas (University of Patras. Department of Chemical Engineering) ;
Kinloch, Ian (University of Manchester. Department of Materials) ;
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Nanosafety & Nanomedicine Laboratory) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Buerki-Thurnherr, Tina (Swiss Federal Laboratories for Materials Science and Technology) ;
Prato, Maurizio (IKERBASQUE) ;
Bianco, Alberto (Centre national de la recherche scientifique. Institut de Biologie Moléculaire et Cellulaire) ;
Wick, Peter (Swiss Federal Laboratories for Materials Science and Technology)
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years in terms of safety assessment. However, limited information is available concerning the hazard potential of GRM-containing products such as graphene-reinforced composites. [...]
2022 - 10.1016/j.jhazmat.2022.129053
Journal of hazardous materials, Vol. 435 (Aug. 2022) , art. 129053
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5.
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16 p, 4.4 MB |
Innate but not adaptive immunity regulates lung recovery from chronic exposure to graphene oxide nanosheets
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Loret, Thomas (Manchester Academic Health Science Centre) ;
De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre) ;
Fordham, Alexander (Manchester Academic Health Science Centre) ;
Arshad, Atta (The University of Manchester. Nanomedicine Lab) ;
Barr, Katharine (The University of Manchester. Nanomedicine Lab) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (Manchester Academic Health Science Centre)
Graphene has drawn a lot of interest in the material community due to unique physicochemical properties. Owing to a high surface area to volume ratio and free oxygen groups, the oxidized derivative, graphene oxide (GO) has promising potential as a drug delivery system. [...]
2022 - 10.1002/advs.202104559
Advanced science, Vol. 9, issue 11 (April 2022)
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6.
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15 p, 2.5 MB |
Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model
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de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ;
Sharp, Paul (University of Manchester. Nanomedicine Lab.) ;
Gurcan, Cansu (Ankara University. Department of Biomedical Engineering) ;
Ceylan, Ahmed (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ;
Stylianou, Maria (University of Manchester. Nanomedicine Lab.) ;
Kisby, Thomas (University of Manchester. Nanomedicine Lab.) ;
Chen, Yingxian (University of Manchester. Nanomedicine Lab.) ;
Vranic, Sandra (University of Manchester. Nanomedicine Lab.) ;
Barr, Katharine (University of Manchester. Nanomedicine Lab.) ;
Taheri, Hadiseh (Ankara University. Department of Biomedical Engineering) ;
Ozen, Asuman (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab.) ;
Yilmazer, Acelya (Ankara University. Department of Biomedical Engineering) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Its anatomical localization, a highly heterogeneous and drug-resistant tumor cell population and a "cold" immune microenvironment, all challenge the treatment of glioblastoma. Nanoscale drug delivery systems, including graphene oxide (GO) flakes, may circumvent some of these issues bypassing biological barriers, delivering multiple cargoes to impact several pathways simultaneously, or targeting the immune compartment. [...]
2021 - 10.1002/adtp.202000109
Advanced Therapeutics, Vol. 4, issue 1 (Jan. 2021) , art. 2000109
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7.
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50 p, 4.9 MB |
Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing aAcute neurotoxicity : a pilot comparison to other nanomaterials
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Portioli, Corinne (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ;
Bussy, Cyrill (Lydia Becker Institute of Immunology and Inflammation) ;
Mazza, Mariarosa (The University of Manchester. Nanomedicine Lab.) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab.) ;
Prato, Maurizio (Ikerbasque) ;
Bianco, Alberto (CNRS. University of Strasbourg. Immunology, Immunopathology and Therapeutic Chemistry) ;
Bentivoglio, Marina (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Carbon-based nanomaterials (CNMs) are being explored for neurological applications. However, systematic in vivo studies investigating the effects of CNM nanocarriers in the brain and how brain cells respond to such nanomaterials are scarce. [...]
2020 - 10.1002/smll.202004029
Small, Vol. 16, issue 48 (Dec. 2020) , art. 2004029
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8.
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19 p, 14.6 MB |
Splenic capture and in vivo intracellular biodegradation of biological-grade graphene oxide sheets
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Newman, Leon (University of Manchester. Nanomedicine Lab.) ;
Jasim, Dhifaf A. (University of Manchester. Nanomedicine Lab.) ;
Prestat, Eric (University of Manchester. Department of Materials) ;
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ;
de Lázaro, Irene (University of Manchester. Nanomedicine Lab.) ;
Nam, Yein (University of Manchester. Nanomedicine Lab.) ;
Assas, Bakri M. (King Abdulaziz University. Department of Immunology) ;
Pennock, Joanne (Lydia Becker Institute of Immunology and Inflammation) ;
Haigh, Sarah J. (University of Manchester. Department of Materials) ;
Bussy, Cyrill (University of Manchester. Nanomedicine Lab.) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Carbon nanomaterials, including 2D graphene-based materials, have shown promising applicability to drug delivery, tissue engineering, diagnostics, and various other biomedical areas. However, to exploit the benefits of these materials in some of the areas mentioned, it is necessary to understand their possible toxicological implications and long-term fate in vivo. [...]
2020 - 10.1021/acsnano.0c03438
ACS nano, Vol. 14, issue 8 (Aug. 2020) , p. 10168-10186
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9.
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17 p, 13.0 MB |
Size-dependent pulmonary impact of thin graphene oxide sheets in mice : toward safe-by-design
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Rodrigues, Artur Filipe (University of Manchester. Nanomedicine Lab) ;
Newman, Leon (University of Manchester. Nanomedicine Lab) ;
Jasim, Dhifaf A (University of Manchester. Nanomedicine Lab) ;
Mukherjee, Sourav P. (Karolinska Institutet (Estocolm, Suècia). Nanosafety & Nanomedicine Laboratory) ;
Wang, Jun (Stockholm University. Department of Biochemistry and Biophysics) ;
Vacchi, Isabella A. (Centre National de la Recherche Scientifique (França)) ;
Ménard-Moyon, Cécilia (Centre National de la Recherche Scientifique (França)) ;
Bianco, Alberto (Centre National de la Recherche Scientifique (França)) ;
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Nanosafety & Nanomedicine Laboratory) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Bussy, Cyrill (Lydia Becker Institute of Immunology and Inflammation)
Safety assessment of graphene-based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors of society. In particular, the link between specific material properties and biological effects needs to be further elucidated. [...]
2020 - 10.1002/advs.201903200
Advanced science, Vol. 7, issue 12 (june 2020) , art. 1903200
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10.
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8 p, 1.5 MB |
Gadolinium-functionalised multi-walled carbon nanotubes as a T1 contrast agent for MRI cell labelling and tracking
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Servant, Ania (University of Manchester) ;
Jacobs, Igor (Eindhoven University of Technology) ;
Bussy, Cyrill (University of Manchester) ;
Fabbro, Chiara (University of Trieste. Department of Pharmaceutical Sciences) ;
Da Ros, Tatiana (University of Trieste. Department of Pharmaceutical Sciences) ;
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia) ;
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia) ;
Prato, Maurizio (University of Trieste. Department of Pharmaceutical Sciences) ;
Nicolay, Klaas (Eindhoven University of Technology. Department of Biomedical Engineering) ;
Kostarelos, Kostas (University of Manchester)
The development of efficient contrast agents for cell labelling coupled with powerful medical imaging techniques is of great interest for monitoring cell trafficking with potential clinical applications such as organ repair and regenerative medicine. [...]
2016 - 10.1016/j.carbon.2015.08.051
Carbon, Vol. 97 (February 2016) , p. 126-133
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