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1.
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27 p, 3.9 MB |
The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks
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Pereira, Quélita Cristina (Sao Francisco University Medical School, Brazil) ;
dos Santos, Tanila Wood (Sao Francisco University Medical School, Brazil) ;
Fortunato, Isabela Monique (Sao Francisco University Medical School, Brazil) ;
Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. [...]
2023 -  10.3390/ijms24065508
International journal of molecular sciences, Vol. 24 Núm. 6 (march 2023)
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2.
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10 p, 1.2 MB |
A randomised phase 2 study comparing different dose approaches of induction treatment of regorafenib in previously treated metastatic colorectal cancer patients (REARRANGE trial)
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Argilés Martínez, Guillem ;
Mulet, N. (Memorial Sloan Kettering Cancer Center) ;
Valladares-Ayerbes, M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Viéitez, J.M. (Hospital Universitario Central de Asturias) ;
Grávalos, Cristina (Hospital Universitario 12 de Octubre (Madrid)) ;
García-Alfonso, P. (H. Gregorio Marañón) ;
Santos, C. (ICO. H. Duran i Reynals) ;
Tobeña, M. (Institut d'Investigació Biomèdica Sant Pau) ;
García Paredes, B. (H. Universitario Clínico San Carlos) ;
Benavides Orgaz, Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Cano, M.T. (H. Universitario Reina Sofía) ;
Loupakis, F. (IOV (Istituto oncologico Veneto)) ;
Rodríguez-Garrote, M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Rivera, F. (Instituto de Investigación Marqués de Valdecilla) ;
Goldberg, R.M. (West Virgina University Cancer Institute) ;
Cremolini, Chiara (A. O. Universitaria Pisana) ;
Bennouna, J. (CHU-Nante) ;
Ciardiello, Fortunato ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Aranda Aguilar, Enrique (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Tabernero, J. (Memorial Sloan Kettering Cancer Center) ;
Falcone, A. (Gustave Roussy) ;
Goldberg, R. ;
Argilés, None (Memorial Sloan Kettering Cancer Center) ;
Tabernero, J. (Memorial Sloan Kettering Cancer Center) ;
Mulet, N. (Memorial Sloan Kettering Cancer Center) ;
Limón, M.L. (H. Virgen del Rocío) ;
Valladares, M. (H. Virgen del Rocío) ;
Jiménez, P. (H. Universitario Central de Asturias) ;
Vieitez, J.M. (H. Universitario Central de Asturias) ;
Grávalos, C. (H. 12 de Octubre) ;
García-Alfonso, P. (H. Gregorio Marañón) ;
Santos, C. (ICO. H. Duran i Reynals) ;
Páez, David (Institut d'Investigació Biomèdica Sant Pau) ;
Sastre Valera, Javier (H. Universitario Clínico San Carlos) ;
García Paredes, B. (H. Universitario Clínico San Carlos) ;
Benavides Orgaz, Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Aranda Aguilar, Enrique (H. Universitario Reina Sofía) ;
Cano, M.T. (H. Universitario Reina Sofía) ;
Loupakis, F. (IOV (Istituto oncologico Veneto)) ;
Rguez Garrote, M. (H. Ramón y Cajal) ;
Guillén, C. (H. Ramón y Cajal) ;
Rivera, M.F. (H. Marqués de Valdecilla) ;
Safont, J. (H. General Universitario) ;
Hiret, S. (Institut de Cancérologie de l'Ouest) ;
Bennouna, J. (CHU-Nante) ;
Pannier, D. (Centre Oscar Lambret) ;
Malka, D. (Gustave Roussy) ;
Falcone, A. (Gustave Roussy) ;
Cremolini, Chiara (A. O. Universitaria Pisana) ;
Universitat Autònoma de Barcelona
Purpose: The purpose of this article is to evaluate the safety of two regorafenib dose-escalation approaches in refractory metastatic colorectal cancer (mCRC) patients. Patients and methods: Patients with mCRC and progression during or within 3 months following their last standard chemotherapy regimen were randomised to receive the approved dose of regorafenib of 160 mg QD (arm A) or 120 mg QD (arm B) administered as 3 weeks of treatment followed by 1 week off, or 160 mg QD 1 week on/1 week off (arm C). [...]
2022 - 10.1016/j.ejca.2022.09.037
European journal of cancer, Vol. 177 (december 2022) , p. 154-163
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3.
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13 p, 1.2 MB |
Effect of polyphenols intake on obesity-induced maternal programming
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Fortunato, Isabela Monique (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ;
Dos Santos, Tanila Wood (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ;
Ferraz, Lucio Fábio Caldas (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ;
Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribeiro, Marcelo Lima (Post Graduate Program in Health Science. Universidade São Francisco (USF))
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. [...]
2021 - 10.3390/nu13072390
Nutrients, Vol. 13 Núm. 7 (july 2021) , p. 2390
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5.
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5 p, 332.1 KB |
Biosimilars : a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers
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Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Vyas, Malvika (European Society for Medical Oncology) ;
Giuliani, Rosa (San Camillo Forlanini Hospital) ;
Arnold, Dirk (CUF Hospitals) ;
Cardoso, Fatima (Champalimaud Clinical Center) ;
Casali, Paolo Giovanni (Fondazione IRCCS National Cancer Institute) ;
Cervantes, Andrés (Clinic Hospital) ;
Eggermont, Alexander (Gustave Roussy Cancer Campus Grand Paris) ;
Eniu, Alexandru (Cancer Institute "Ion Chiricuta") ;
Jassem, Jacek (Medical University of Gdansk) ;
Pentheroudakis, George (University of Ioannina) ;
Peters, Solange (Centre Hospitalier Universitaire Vaudois) ;
Rauh, Stefan (Hospital Center Emile Mayrisch) ;
Zielinski, Christoph C. (Medical University of Vienna) ;
Stahel, Rolf A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Voest, Emile (University Hospital Zurich (Suïssa)) ;
Douillard, Jean-Yves (European Society for Medical Oncology) ;
McGregor, Keith (European Society for Medical Oncology) ;
Ciardiello, Fortunato (Second University of Naples) ;
Universitat Autònoma de Barcelona
Biosimilars present a necessary and timely opportunity for physicians, patients and healthcare systems. If suitably developed clinically, manufactured to the correct standards and used appropriately, they can positively impact on the financial sustainability of healthcare systems. [...]
2017 - 10.1136/esmoopen-2016-000142
ESMO open, Vol. 1 (january 2017)
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6.
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5 p, 637.4 KB |
Educational needs in gastrointestinal cancer : a consensus position paper from the ESMO Gastrointestinal Cancer Faculty
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Lordick, Florian (Leipzig University Medical Center) ;
Obermannova, Radka (Masaryk University) ;
Vola, Doris (European Society for Medical Oncology) ;
Douillard, Jean-Yves (European Society for Medical Oncology) ;
Mcgregor, Keith (European Society for Medical Oncology) ;
Van Cutsem, Eric (University Hospitals Leuven (Bèlgica)) ;
Tabernero, Josep (Universitat Autònoma de Barcelona) ;
Ciardiello, Fortunato (Second University of Naples) ;
Cervantes, Andrés (Universitat de València)
Gastrointestinal (GI) cancers are common in all parts of the world. Effective prevention and early detection of GI cancers are not universally implemented. Therefore, it must be anticipated that the incidence and the mortality of GI cancers will remain high within the next decades. [...]
2019 - 10.1136/esmoopen-2019-000533
ESMO open, Vol. 4 (july 2019)
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7.
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19 p, 418.6 KB |
Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer : Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study
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Van Cutsem, Eric (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Huijberts, Sanne (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Grothey, Axel (West Cancer Center, Germantown, TN) ;
Yaeger, Rona (Memorial Sloan Kettering Cancer Center) ;
Cuyle, Pieter-Jan (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Elez, Elena (Vall d'Hebron Institut d'Oncologia) ;
Fakih, Marwan (City of Hope National Medical Center (Duarte, Estats Units d'Amèrica)) ;
Montagut, Clara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Peeters, Marc (University Hospital Antwerp (Bèlgica)) ;
Yoshino, Takayuki (National Cancer Center Hospital East, Kashiwa, Japan) ;
Wasan, Harpreet (Hammersmith Hospital (Londres)) ;
Desai, Jayesh (Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia) ;
Ciardiello, Fortunato (University of Campania "Luigi Vanvitelli" (Nàpols, Itàlia)) ;
Gollerkeri, Ashwin (Array BioPharma Inc) ;
Christy-Bittel, Janna (Array BioPharma Inc) ;
Maharry, Kati (Array BioPharma Inc) ;
Sandor, Victor (Array BioPharma Inc) ;
Schellens, Jan H. M. (Utrecht University) ;
Kopetz, Scott (The University of Texas MD Anderson Cancer Center, Houston, TX) ;
Tabernero, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vall d'Hebron Institut de Recerca (VHIR)
To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, phase III BEACON Colorectal Cancer trial ( identifier: ; European Union Clinical Trials Register identifier: EudraCT2015-005805-35). [...]
2019 - 10.1200/JCO.18.02459
Journal of Clinical Oncology, Vol. 37 (march 2019) , p. 1460-1469
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8.
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9 p, 325.6 KB |
Nintedanib for the treatment of patients with refractory metastatic colorectal cancer (LUME-Colon 1) : a phase III, international, randomized, placebo-controlled study
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Van Cutsem, E. (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Yoshino, Takayuki (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan) ;
Lenz, H. J. (Division of Medical Oncology, Norris Comprehensive Cancer Center, Los Angeles, USA) ;
Lonardi, Sara (Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto - IRCCS, Padua) ;
Falcone, Alfredo (Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy) ;
Limón, M. L. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Saunders, M. (Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK) ;
Sobrero, A. (Department of Medical Oncology, Azienda Ospedaliera San Martino, Genoa, Italy) ;
Park, Y S. (Department of Hematology and Oncology, Samsung Medical Center, Seoul, South Korea) ;
Ferreiro, R. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Hong, Y S. (Department of Oncology, Asan Medical Center, Seoul, South Korea) ;
Tomasek, J. (Masaryk Memorial Cancer Institute (Brno, República Txeca)) ;
Taniguchi, H. (Aichi Cancer Center Hospital) ;
Ciardiello, Fortunato (Oncologia Medica, Seconda Università deli Studi di Napoli, Naples, Italy) ;
Stoehr, J. (Boehringer Ingelheim, Pharma GmbH & Co. KG, Biberach, Germany) ;
Oum'Hamed, Z. (Boehringer Ingelheim France S.A.S, Reims, France) ;
Vlassak, S. (SCS Boehringer Ingelheim Comm.V, Brussels, Belgium) ;
Studeny, M. (Division of Medicine/Clinical Development Department, Boehringer Ingelheim, Vienna, Austria) ;
Argiles, G.. (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Angiogenesis is critical to colorectal cancer (CRC) growth and metastasis. Phase I/II studies have demonstrated the efficacy of nintedanib, a triple angiokinase inhibitor, in patients with metastatic CRC. [...]
2018 - 10.1093/annonc/mdy241
Annals of oncology, Vol. 29 (july 2018) , p. 1955-1963
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9.
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9 p, 351.5 KB |
Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS -mutant metastatic colorectal cancer
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Elez, Elena (Vall d'Hebron Institut d'Oncologia) ;
Chianese, Chiara (Vall d'Hebron Institut d'Oncologia) ;
Sanz-García, Enrique (Vall d'Hebron Institut d'Oncologia) ;
Martinelli, Erica (Università della Campania 'L. Vanvitelli') ;
Noguerido, Alba (Vall d'Hebron Institut d'Oncologia) ;
Mancuso, Francesco M. (Vall d'Hebron Institut d'Oncologia) ;
Caratù, Ginevra (Vall d'Hebron Institut d'Oncologia) ;
Matito, Judit (Vall d'Hebron Institut d'Oncologia) ;
Grasselli, Julieta (Vall d'Hebron Institut d'Oncologia) ;
Cardone, Claudia (Università della Campania 'L. Vanvitelli') ;
Esposito Abate, Riziero (Istituto Nazionale Tumori 'Fondazione Giovanni Pascale' IRCCS) ;
Martini, Giulia ;
Santos Vivas, Cristina (Universitat de Barcelona) ;
Macarulla Mercadé, Teresa (Vall d'Hebron Institut d'Oncologia) ;
Argilés Martínez, Guillem (Vall d'Hebron Institut d'Oncologia) ;
Garcia, Ariadna (Vall d'Hebron Institut d'Oncologia) ;
Mulet, Nuria (Universitat de Barcelona) ;
Maiello, Evaristo (IRCCS Casa Sollievo della Sofferenza) ;
Normanno, Nicola (Istituto Nazionale Tumori 'Fondazione Giovanni Pascale' IRCCS) ;
Jones, Frederick (Sysmex Inostics) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Ciardello, Fortunato (Università della Campania 'L. Vanvitelli') ;
Salazar, Ramon (Universitat de Barcelona) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Despite major advances in the treatment of metastatic colorectal cancer (mCRC), the survival rate remains very poor. This study aims at exploring the prognostic value of RAS -mutant allele fraction (MAF) in plasma in mCRC. [...]
2019 - 10.1002/1878-0261.12547
Molecular Oncology, Vol. 13 (july 2019) , p. 1827-1835
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10.
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93 p, 11.3 MB |
Towards Oxide Electronics : a Roadmap
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Coll, Mariona (Institut de Ciència de Materials de Barcelona) ;
Fontcuberta, Josep (Institut de Ciència de Materials de Barcelona) ;
Althammer, Matthias (Technische Universität München. Physik Department) ;
Bibes, Manuel (Unité Mixte de Physique) ;
Boschker, Hans (Max Planck Institute for Solid State Research) ;
Calleja, Ana (OXOLUTIA S.L.) ;
Cheng, Guanglei (Pittsburgh Quantum Institute) ;
Cuoco, Mario (Università di Salerno) ;
Dittmann, Regina (Peter Grünberg Institut) ;
Dkhil, Brahim (Université Paris-Saclay) ;
El Baggari, Ismail (Cornell University) ;
Fanciulli, Marco (University of Milano Bicocca. Department of Materials Science) ;
Fina, Ignasi (Institut Català de Nanociència i Nanotecnologia) ;
Fortunato, Elvira (CEMOP/UNINOVA) ;
Frontera, Carlos (Institut de Ciència de Materials de Barcelona) ;
Fujita, Shizuo (Kyoto University) ;
Garcia, Vincent (Unité Mixte de Physique) ;
Goennenwein, Sebastian T. B. (Technische Universität Dresden) ;
Granqvist, Claes Göran (Upp sala University) ;
Grollier, Julie (Unité Mixte de Physique) ;
Gross, Rudolf (Nanosystems Initiative Munich (NIM)) ;
Hagfeldt, Anders (Ecole Polytechnique Fédérale de Lausanne) ;
Herranz Casabona, Gervasi (Institut de Ciència de Materials de Barcelona) ;
Hono, Kazuhiro (National Institute for Materials Science) ;
Houwman, Evert (University of Twente) ;
Huijben, Mark (University of Twente) ;
Kalaboukhov, Aleksey (MC2. Chalmers University of Technology) ;
Keeble, David J. (University of Dundee) ;
Koster, Gertjan (University of Twente) ;
Kourkoutis, Lena Fitting (Cornell University) ;
Levy, Jeremy (Pittsburgh Quantum Institute) ;
Lira-Cantu, Monica (Institut Català de Nanociència i Nanotecnologia) ;
MacManus-Driscoll, Judith L. (University of Cambridge. Department of Materials Science and Metallurgy) ;
Mannhart, Jochen (Max Planck Institute for Solid State Research) ;
Martins, Rodrigo (MDM Laboratory) ;
Menzel, Stephan (Pittsburgh Quantum Institute) ;
Mikolajick, Thomas (Chair of Nanoelectronic Materials) ;
Napari, Mari (University of Cambridge. Department of Materials Science and Metallurgy) ;
Nguyen, Duc Minh (University of Twente) ;
Niklasson, Gunnar A. (Uppsala University) ;
Paillard, Charles (University of Arkansas. Physics Department) ;
Panigrahi, Shrabani (CEMOP/UNINOVA) ;
Rijnders, Guus (University of Twente) ;
Sánchez Barrera, Florencio (Institut de Ciència de Materials de Barcelona) ;
Sanchis Kilders, Pablo (Universitat Politècnica de València) ;
Sanna, S. (Technical University of Denmark. Department of Energy Storage and Conversion) ;
Schlom, Darrell G (Cornell University. Department of Material Science and Engineering) ;
Schroeder, U. (NaMLab gGmbH) ;
Shen, K. M. (Cornell University. Department of Physics) ;
Siemon, A. (Institut für Werkstoffe der Elektrotechnik) ;
Spreitzer, M. (Jožef Stefan Institute) ;
Sukegawa, H. (Research Center for Magnetic and Spintronic Materials) ;
Tamayo, R. (OXOLUTIA S.L.) ;
van den Brink, J. (Institute for Theoretical Solid State Physics) ;
Pryds, N. (Technical University of Denmark. Department of Energy Storage and Conversion) ;
Granozio, F. M. (CNR-SPIN. Naples Unit)
At the end of a rush lasting over half a century, in which CMOS technology has been experiencing a constant and breathtaking increase of device speed and density, Moore's law is approaching the insurmountable barrier given by the ultimate atomic nature of matter. [...]
2019 - 10.1016/j.apsusc.2019.03.312
Applied surface science, Vol. 482 (July 2019) , p. 1-93
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