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Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna C. ;
Damrauer, Scott M. ;
de Vries, Paul S. ;
Smith, Nicholas L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 -  10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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12 p, 1.7 MB |
Roles of lncRNAs in brain development and pathogenesis : Emerging therapeutic opportunities
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Srinivas, Tara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mathias, Carolina (Federal University of Parana, Curitiba, Brazil) ;
Oliveira-Mateos, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The human genome is pervasively transcribed, producing a majority of short and long noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of transcriptional and post-transcriptional regulatory mechanisms. [...]
2023 - 10.1016/j.ymthe.2023.02.008
Molecular Therapy, Vol. 31 Núm. 6 (july 2023) , p. 1550-1561
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8 p, 1.0 MB |
Plain language summary of the MajesTEC-1 study of teclistamab for the treatment of people with relapsed or refractory multiple myeloma
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Moreau, Philippe (University Hospital Hôtel-Dieu) ;
Van De Donk, Niels WCJ (Department of Hematology. Amsterdam University Medical Center) ;
Nahi, Hareth (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Nooka, Ajay K (Winship Cancer Institute. Emory University) ;
Martin, Thomas (University of California San Francisco) ;
Rosinol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Karlin, Lionel (Centre Hospitalier Lyon Sud) ;
Benboubker, Lotfi (Hôpital Bretonneau) ;
Mateos, Maria-Victoria (University Hospital de Salamanca) ;
Popat, Rakesh (University College London Hospitals) ;
Martínez-López, Joaquín (Hospital Universitario 12 de Octubre (Madrid)) ;
Sidana, Surbhi (Stanford University of Medicine) ;
Delforge, Michele (University of Leuven) ;
Pei, Lixia (Janssen Research & Development) ;
Trancucci, Danielle (Janssen Research & Development) ;
Olyslager, Yunsi (Janssen Research & Development) ;
Uhlar, Clarissa (Janssen Research & Development) ;
Stephenson, Tara (Janssen Research & Development) ;
Rampelbergh, Rian Van (Janssen Research & Development) ;
Banerjee, Arnob (Janssen Research & Development) ;
Kobos, Rachel (Janssen Research & Development) ;
Usmani, Saad Z (Levine Cancer Institute-Atrium Health)
What is this summary about? This is a summary of a phase 1-2 clinical trial called MajesTEC-1. This trial tested the cancer drug teclistamab in people with relapsed or refractory multiple myeloma, a cancer that forms in a certain type of white blood cells known as plasma cells. [...]
2023 - 10.2217/fon-2023-0171
Future oncology (London, England), Vol. 19 Núm. 12 (january 2023) , p. 811-818
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8 p, 697.1 KB |
CONCEPTT : Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial: A multi-center, multi-national, randomized controlled trial - Study protocol
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Feig, Denice S. (Mt Sinai Hospital) ;
Asztalos, Elizabeth (Sunnybrook Research Institute) ;
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
De Leiva, Alberto (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Donovan, Lois (Alberta Health Services) ;
Hod, Moshe (Helen Schneider Hospital for Women) ;
Jovanovic, Lois ;
Keely, Erin (The Ottawa Hospital) ;
Kollman, Craig (Jaeb Center For Health Research) ;
McManus, Ruth (St. Joseph's Health Centre) ;
Murphy, Kellie (Lunenfeld-Tanenbaum Research Institute) ;
Ruedy, Katrina (Jaeb Center For Health Research) ;
Sanchez, J.Johanna (Sunnybrook Research Institute) ;
Tomlinson, George (Toronto General Hospital) ;
Murphy, Helen R. (Norwich Medical School) ;
Cleave, Barbara (Mt Sinai Hospital) ;
Donat, Diane (Mt Sinai Hospital) ;
Gandhi, Shital (Mt Sinai Hospital) ;
Strom, Michelle (Mt Sinai Hospital) ;
Chico Ballesteros, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
José Martínez, Mª (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Sánchez, Mireia (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Tundidor, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Amiel, Stephanie (King's College Hospital NHS Foundation Trus) ;
Hunt, Katharine (King's College Hospital NHS Foundation Trust) ;
Green, Louisa (King's College Hospital NHS Foundation Trust) ;
Rogers, Helen (King's College Hospital NHS Foundation Trust) ;
Rossi, Benedetta (King's College Hospital NHS Foundation Trust) ;
Stodhart, Ben (King's College Hospital NHS Foundation Trust) ;
Bonomo, Matteo (Niguarda ca' Granda Hospital) ;
Bertuzzi, Federico (Niguarda ca' Granda Hospital) ;
Corica, Giuseppina D. (Niguarda ca' Granda Hospital) ;
Fazio, Silvana (Niguarda ca' Granda Hospital) ;
Giro, Ropberto (Niguarda ca' Granda Hospital) ;
Mion, Elena (Niguarda ca' Granda Hospital) ;
Moletta, Andrea (Niguarda ca' Granda Hospital) ;
Pintaudi, Basilio (Niguarda ca' Granda Hospital) ;
Sorrentino, Rosa (Niguarda ca' Granda Hospital) ;
Booth, John (McMaster University (Canadà)) ;
McInnes, Natalia (McMaster University (Canadà)) ;
Nykamp, Adelle (McMaster University (Canadà)) ;
Otto, Rose (McMaster University (Canadà)) ;
Smith, Ada (McMaster University (Canadà)) ;
Stanton, Irene (McMaster University (Canadà)) ;
Tazzeo, Tracy (McMaster University (Canadà)) ;
Oldford, Carolyn (University of Calgary) ;
Young, Catherine (University of Calgary) ;
Gougeon, Claire (University of Calgary) ;
Houlden, Robyn (Queen's University) ;
Breen, Adriana (Queen's University) ;
Castorino, Kristin (Diabetes Center) ;
Sansum, William (Diabetes Center) ;
Erin Keely, None (The Ottawa Hospital General Campus) ;
Clark, Heather (The Ottawa Hospital General Campus) ;
Gaudet, Laura (The Ottawa Hospital General Campus) ;
Karovitch, Alan (The Ottawa Hospital General Campus) ;
Malcolm, Janine (The Ottawa Hospital General Campus) ;
Lowe, Julia (Sunnybrook Health Sciences Centre (Toronto)) ;
Rogowsky, Anna (Sunnybrook Health Sciences Centre (Toronto)) ;
Kudirka, Anne (St. Joseph's Health Centre) ;
Watson, Margaret (St. Joseph's Health Centre) ;
Morris, Damian (Ipswich Hospital NHS Trust) ;
Farnworth, Frances (Ipswich Hospital NHS Trust) ;
Fowler, Duncan (Ipswich Hospital NHS Trust) ;
Mitchell, Sue (Ipswich Hospital NHS Trust) ;
Rosier, Josephine (Ipswich Hospital NHS Trust) ;
Murphy, Helen (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Byrne, Caroline (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Davenport, Katy (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Grisoni, Jeannie (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Mulrennan, Sandra (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Neoh, Sandra (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
O'Sullivan, Esther (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Simmons, David (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Stewart, Zoe (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Templin, Heike (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Helen Murphy, None (Norfolk and Norwich University Hospital) ;
Turner, Jeremy (Norfolk and Norwich University Hospital) ;
Canciani, Gioia (Norfolk and Norwich University Hospital) ;
Hewapathirana, Niranjala (Nilu) (Norfolk and Norwich University Hospital) ;
Jones, Louise (Norfolk and Norwich University Hospital) ;
Piper, Leanne (Norfolk and Norwich University Hospital) ;
Temple, Rosemary (Norfolk and Norwich University Hospital) ;
Wallace, Tara (Norfolk and Norwich University Hospital) ;
Maitland, Rahat (Guys and St Thomas' NHS Foundation Trust) ;
Banerjee, Anita (Guys and St Thomas' NHS Foundation Trust) ;
Briley, Anette (Guys and St Thomas' NHS Foundation Trust) ;
Brackenridge, Anna (Guys and St Thomas' NHS Foundation Trust) ;
Gilby, Pam (Guys and St Thomas' NHS Foundation Trust) ;
Gill, Carolyn (Guys and St Thomas' NHS Foundation Trust) ;
Reid, Anna (Guys and St Thomas' NHS Foundation Trust) ;
Singh, Claire (Guys and St Thomas' NHS Foundation Trust) ;
White, Sara (Guys and St Thomas' NHS Foundation Trust) ;
Wolfs, Maria (St. Michael's Hospital) ;
Scott, Eleanor (Leeds Teaching Hospitals NHS Trust) ;
Endersby, Del (Leeds Teaching Hospitals NHS Trust) ;
Maresh, Michael (Central Manchester University Hospitals NHS Foundation Trust) ;
Kearney, Gretta (Central Manchester University Hospitals NHS Foundation Trust) ;
Morris, Juliet (Central Manchester University Hospitals NHS Foundation Trust) ;
Quinn, Susan (Central Manchester University Hospitals NHS Foundation Trust) ;
Rao-Balakrishna, Prasanna (Central Manchester University Hospitals NHS Foundation Trust) ;
MacDougall, Malcolm (Royal Victoria Infirmary) ;
Bilous, Rudy (South Tees Hospitals. NHS Foundation Trust) ;
Bilous, Mary (South Tees Hospitals. NHS Foundation Trust) ;
Mahadissu, Shilpa (South Tees Hospitals. NHS Foundation Trust) ;
Menini, Deepika (South Tees Hospitals. NHS Foundation Trust) ;
Mukhtar, Rasha (South Tees Hospitals. NHS Foundation Trust) ;
Holt, Richard (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Forbes, Jane (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Martin, Nicki (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Walbridge, Fiona (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Mansell, Peter (Queen's Medical Centre) ;
Babington, Gayna (Queen's Medical Centre) ;
Bugg, George (Queen's Medical Centre) ;
Gazis, Tasso (Queen's Medical Centre) ;
Nia Jones, None (Queen's Medical Centre) ;
Spick, Dawn (Queen's Medical Centre) ;
Heller, Simon (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Bustani, Rebbeca (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Gordon, Val (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Madhuvrata, Priya (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Hudson, Sue (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Nisbet, Chloe (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Novodvorsky, Peter (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Solomon, Alexandra (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Towse, Karen (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Philip, Sam (Grampian Diabetes Centre) ;
Booth, Anne (Grampian Diabetes Centre) ;
Cadzow, Ann (Grampian Diabetes Centre) ;
Chlost, Martyna (Grampian Diabetes Centre) ;
Murray, Lynne (Grampian Diabetes Centre) ;
Karen Norris, None (Grampian Diabetes Centre) ;
Shearer, K.atrina (Grampian Diabetes Centre) ;
Dover, Anna (Royal Infirmary of Edinburgh) ;
Dougherty, Frances (Royal Infirmary of Edinburgh) ;
Johnston, Susan (Royal Infirmary of Edinburgh) ;
Little, Jill (Royal Infirmary of Edinburgh) ;
McKay, Liz (Royal Infirmary of Edinburgh) ;
Lindsay, Robert (Glasgow Royal Infirmary) ;
Carty, David (Glasgow Royal Infirmary) ;
Crawford, Isobel (Glasgow Royal Infirmary) ;
Mackenzie, Fiona (Glasgow Royal Infirmary) ;
McSorley, Therese (Glasgow Royal Infirmary) ;
Dunne, Fidelma (Galway University Hospitals) ;
Brosnan, Elizabeth (Galway University Hospitals) ;
Conway, Sharon (Galway University Hospitals) ;
Byrnes, Michelle Courcy (Galway University Hospitals) ;
Duane, Linda (Galway University Hospitals) ;
Duffy, Niamh (Galway University Hospitals) ;
Egan, Aoife (Galway University Hospitals) ;
Gaffney, Geraldine (Galway University Hospitals) ;
Higgins, Grainne (Galway University Hospitals) ;
Kelly, Caroline (Galway University Hospitals) ;
Kirwan, Collette (Galway University Hospitals) ;
Liew, Aaron (Galway University Hospitals) ;
Normoyle, Kevin (Galway University Hospitals) ;
Roarty, Christina (Galway University Hospitals) ;
Waldron, Mairead (Galway University Hospitals) ;
Weisnagel, John (Centre hospitalier universitaire de Québec) ;
Allen, Christyne (Centre hospitalier universitaire de Québec) ;
D'Amours, Martin (Centre hospitalier universitaire de Québec) ;
Dubé, Marie-Christine (Centre hospitalier universitaire de Québec) ;
Julien, Valérie-Eve (Centre hospitalier universitaire de Québec) ;
Godbout, Ariane (Hôpital St. Luc) ;
Daigle, Sylvie (Hôpital St. Luc) ;
Ransom, Thomas (Izaak Walton Killam Health Sciences Centre (IWK)) ;
Coolen, Jill (Izaak Walton Killam Health Sciences Centre (IWK)) ;
Baxendale, Darlene (Izaak Walton Killam Health Sciences Centre (IWK)) ;
Newstead-Angel, Jill (Royal University Hospital) ;
Soloman, Alexandra L. (Russells Hall Hospital) ;
Gorton, Karen (Russells Hall Hospital) ;
Jackson, Margaret (Russells Hall Hospital) ;
Miller, Kirsty (Russells Hall Hospital) ;
Taylor, Julie (Russells Hall Hospital) ;
Mergler, Sonya (The Centre for Mother. Infant and Child Research (CMICR)) ;
Qureshi, Asma (The Centre for Mother. Infant and Child Research (CMICR)) ;
Rodriguez, Adriana (The Centre for Mother. Infant and Child Research (CMICR)) ;
Mangoff, Kathryn (The Centre for Mother. Infant and Child Research (CMICR)) ;
Universitat Autònoma de Barcelona
Women with type 1 diabetes strive for optimal glycemic control before and during pregnancy to avoid adverse obstetric and perinatal outcomes. For most women, optimal glycemic control is challenging to achieve and maintain. [...]
2016 - 10.1186/s12884-016-0961-5
BMC Pregnancy and Childbirth, Vol. 16 Núm. 1 (18 2016) , p. 167
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6.
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50 p, 28.5 MB |
Pan-cancer proteogenomics connects oncogenic drivers to functional states
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Li, Yize (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tokheim, Collin (Harvard T.H. Chan School of Public Health) ;
Bailey, Matthew H. (Brigham Young University) ;
Yaron, Tomer (Weill Cornell Medicine) ;
Stathias, Vasileios (University of Miami Miller School of Medicine) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cao, Song (McDonnell Genome Institute) ;
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Liu, Wenke (NYU Grossman School of Medicine) ;
Wyczalkowski, Matthew A. (McDonnell Genome Institute) ;
Song, Yizhe (McDonnell Genome Institute) ;
Storrs, Erik P. (McDonnell Genome Institute) ;
Wendl, Michael C. (Washington University in St. Louis) ;
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units)) ;
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Liang, Wen-Wei (McDonnell Genome Institute) ;
Terekhanova, Nadezhda V. (McDonnell Genome Institute) ;
Martins Rodrigues, Fernanda (McDonnell Genome Institute) ;
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Calinawan, Anna Pamela (Icahn School of Medicine at Mount Sinai) ;
Dhanasekaran, Saravana Mohan (University of Michigan) ;
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhou, Daniel Cui (McDonnell Genome Institute) ;
Wang, Liang-Bo (McDonnell Genome Institute) ;
Baral, Jessika (McDonnell Genome Institute) ;
Johnson, Jared L. (Weill Cornell Medicine) ;
Huntsman, Emily M. (Weill Cornell Medicine) ;
Pugliese, Pietro (University of Sannio (Benevento, Itàlia)) ;
Colaprico, Antonio (University of Miami Miller School of Medicine) ;
Iavarone, Antonio (University of Miami Miller School of Medicine) ;
Chheda, Milan G. (Washington University in St. Louis) ;
Ricketts, Christopher J. (National Institutes of Health) ;
Fenyö, David (NYU Grossman School of Medicine) ;
Payne, Samuel H. (Brigham Young University) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Gillette, Michael A. (Harvard Medical School) ;
Kumar-Sinha, Chandan (University of Michigan) ;
Lazar, Alexander (The University of Texas MD Anderson Cancer Center) ;
Cantley, Lewis (Weill Cornell Medicine) ;
Getz, Gad A. (Harvard Medical School) ;
Ding, Li (Siteman Cancer Center) ;
An, Eunkyung ;
Anurag, Meenakshi ;
Bavarva, Jasmin ;
Birrer, Michael J. ;
Ceccarelli, Michele ;
Chan, Daniel W. ;
Chinnaiyan, Arul M. ;
Cho, Hanbyul ;
Chowdhury, Shrabanti ;
Cieslik, Marcin P. ;
da Veiga Leprevost, Felipe ;
Day, Corbin ;
Domagalski, Marcin J. ;
Dou, Yongchao ;
Druker, Brian J. ;
Edwards, Nathan ;
Ellis, Matthew J. ;
Selvan, Myvizhi Esai ;
Foltz, Steven M. ;
Francis, Alicia ;
Gonzalez Robles, Tania J. ;
Gosline, Sara J. C. ;
Gümüş, Zeynep H. ;
Hiltke, Tara ;
Hong, Runyu ;
Hostetter, Galen ;
Hu, Yingwei ;
Huang, Chen ;
Huntsman, Emily ;
Jaehnig, Eric J. ;
Jewel, Scott D. ;
Ji, Jiayi ;
Jiang, Wen ;
Katsnelson, Lizabeth ;
Ketchum, Karen A. ;
Kolodziejczak, Iga ;
Lei, Jonathan T. ;
Liao, Yuxing ;
Lindgren, Caleb M. ;
Liu, Tao ;
Ma, Weiping ;
McKerrow, Wilson ;
Nesvizhskii, Alexey I. ;
Newton, Chelsea ;
Oldroyd, Robert ;
Omenn, Gilbert S. ;
Paulovich, Amanda G. ;
Petralia, Francesca ;
Reva, Boris ;
Rodland, Karin D. ;
Ruggles, Kelly V. ;
Rykunov, Dmitry ;
Savage, Sara R. ;
Schadt, Eric E. ;
Schnaubelt, Michael ;
Schraink, Tobias ;
Shi, Zhiao ;
Smith, Richard D. ;
Song, Xiaoyu ;
Tan, Jimin ;
Thangudu, Ratna R. ;
Tignor, Nicole ;
Wang, Joshua M. ;
Wang, Pei ;
Wang, Ying Cindy ;
Wen, Bo ;
Wiznerowicz, Maciej ;
Yi, Xinpei ;
Zhang, Bing ;
Zhang, Hui ;
Zhang, Xu ;
Zhang, Zhen ;
Universitat Autònoma de Barcelona
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. [...]
2023 - 10.1016/j.cell.2023.07.014
Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25
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7.
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16 p, 6.0 MB |
Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
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Antoszewski, Mateusz (Swiss Cancer Center Leman (SCCL) Lausanne, Switzerland) ;
Fournier, Nadine (Swiss Cancer Center Leman (SCCL) Lausanne, Switzerland) ;
Ruiz Buendía, Gustavo A. (Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland) ;
Lourenco, Joao (Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland) ;
Liu, Yuanlong (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland) ;
Sugrue, Tara (University of Basel & ETH Zürich, Basel, Switzerland) ;
Dubey, Christelle (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland) ;
Nkosi, Marianne (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland) ;
Pritchard, Colin E.J. (The Netherlands Cancer Institute, Amsterdam, The Netherlands) ;
Huijbers, Ivo J. (University of Amsterdam, The Netherlands) ;
Segat, Gabriela C. (Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada) ;
Alonso-Moreno, Sandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serracanta, Elisabeth (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Belver, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrando, Adolfo A. (Columbia University Medical Center, New York (USA)) ;
Ciriello, Giovanni (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland) ;
Weng, Andrew P. (Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada) ;
Koch, Ute (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland) ;
Radtke, Freddy (Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland)
NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape during T-ALL initiation is unknown. [...]
2022 - 10.1182/blood.2021012077
Blood, Vol. 139 Núm. 16 (april 2022) , p. 2483-2498
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8.
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11 p, 897.2 KB |
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin (University of Lille) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Schirmer, Markus D. (Massachusetts General Hospital) ;
Hong, Sungmin (Massachusetts General Hospital) ;
Dalca, Adrian V. (Massachusetts Institute of Technology) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Giese, Anne-Katrin (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Rist, Pamela M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Nardin, Marco (Massachusetts General Hospital) ;
Marinescu, Razvan (Massachusetts Institute of Technology) ;
Wang, Clinton (Massachusetts Institute of Technology) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Leclerc, Xavier (University of Lille) ;
Lopes, Renaud (Institut Pasteur de Lille) ;
Benavente, Oscar R. (Department of Medicine, University of British Columbia) ;
Cole, John W. (Department of Neurology, University of Maryland School of Medicine a) ;
Donatti, Amanda (School of Medical Sciences, University of Campinas (Brasil)) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Department of Neurology, Washington University School of Medicine) ;
Holmegaard, Lukas (Sahlgrenska Academy at University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (Department of Neurology, University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (Department of Neurology, John Hunter Hospital) ;
McArdle, Patrick F. (Department of Medicine, University of Maryland School of Medicine) ;
McDonough, Caitrin W. (Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine) ;
Rolfs, Arndt (Centogene (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Roquer, Jaume (Department of Neurology, University of Miami) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University of Graz) ;
Sharma, Pankaj (St. Peter's Hospitals (Regne Unit)) ;
Slowik, Agnieszka (Department of Neurology, Jagiellonian University Medical College) ;
Sousa, Alessandro (Department of Neurology, University of Maryland School of Medicine) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Department of Neurology, Helsinki University Central Hospital) ;
Tatlisumak, Turgut (Department of Neurology, Sahlgrenska University Hospital) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Department of Neurology Austin Health) ;
Vagal, Achala (Department of Radiology, University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine) ;
Wu, Ona (Massachusetts General Hospital) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
Worrall, Bradford B. (Department of Neurology and Public Health Sciences, University of Virginia) ;
Maguire, Jane M. (University of Technology Sydney) ;
Lindgren, Arne (Department of Clinical Sciences Lund, Lund University) ;
Jern, Christina (Sahlgrenska Academy at University of Gothenburg) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Kuchcinski, Grégory (University of Lille) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. [...]
2021 - 10.3389/fnins.2021.691244
Frontiers in Neuroscience, Vol. 15 (july 2021)
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10 p, 678.7 KB |
Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke
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Hong, Sungmin (Massachusetts General Hospital) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Schirmer, Markus D. (University Hospital Bonn) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Bretzner, Martin (Université du Lille) ;
Rist, Pamela (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Dalca, Adrian V. (Department of Radiology, Massachusetts General Hospital) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Nardin, Marco (Harvard Medical School) ;
Mocking, Steven J. T. (Massachusetts General Hospital) ;
McIntosh, Elissa C. (Massachusetts General Hospital) ;
Attia, John (University of Newcastle) ;
Benavente, Oscar R. (University of British Columbia) ;
Cole, John W. (University of Maryland. School of Medicine) ;
Donatti, Amanda (University of Campinas) ;
Griessenauer, Christoph J. (Research Institute of Neurointervention, Paracelsus Medical University) ;
Heitsch, Laura (Washington University School of Medicine) ;
Holmegaard, Lukas (University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital) ;
Rolfs, Arndt (Centogene AG (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology , University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University Graz) ;
Enzinger, Christian (Department of Neurology, Medical University Graz) ;
Sharma, Pankaj (St. Peter's and Ashford Hospitals) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Sousa, Alessandro (University of Campinas) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (University of Helsinki) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Thijs, Vincent (Austin Health (Austràlia)) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Geisinger (Estats Units d'Amèrica)) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Wu, Ona (Massachusetts General Hospital) ;
Jern, Christina (Department of University of Gothenburg) ;
Lindgren, Arne G. (Lund University. Department of Clinical Sciences) ;
Maguire, Jane (University of Technology Sydney) ;
Tomppo, Liisa (University of Helsinki) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. [...]
2021 - 10.3389/fneur.2021.700616
Frontiers in neurology, Vol. 12 (september 2021)
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10.
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11 p, 4.4 MB |
Mining coal while digging for justice : Investigating justice claims against a coal-phase out in five countries
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Busch, Henner (Lunds Universitet Centre for Sustainability Studies) ;
Ramasar, Vasna (Lund University. Department of Human Geography) ;
Avila, Sofía (Universidad Nacional Autónoma de México. Instituto de Investigaciones Sociales) ;
Roy, Brototi (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
van Ryneveld, Tara (Lund University. Department of Human Geography) ;
Mandinic, Ana (Lund University. Department of Human Geography) ;
Brandstedt, Eric (Lund University. Department of History)
Coal has long been one of the fossil fuels underpinning the energy systems of many countries around the world. Because of its long-standing history, many actors have an interest in retaining the status quo. [...]
2023 - 10.1016/j.exis.2023.101275
The extractive industries and society, Vol. 15 (September 2023) , art. 101275
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