Proteome response at the edge of protein aggregation
Sánchez de Groot, Natalia (MRC Laboratory of Molecular Biology)
Gomes, Ricardo A. (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier)
Villar Pique, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research)
Babu, Madam M (MRC Laboratory of Molecular Biology)
Varela Coelho, Ana (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier)
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"

Date:	2015
Abstract:	Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison of two amyloid-β-peptide variants, mostly insoluble but differently recruited by the cell (inclusion body versus diffused), reveals small differences in cell fitness and proteome response. We suggest that the levels of oxidative stress act as a sensor to trigger protein recruitment into foci. Our data support a common cytoplasmic response being able to discern and react to the specific properties of polypeptides.
Grants:	European Commission 299105 Ministerio de Economía y Competitividad BFU2013-44763 Ministerio de Ciencia e Innovación AIB2010PT-00110 Ministerio de Ciencia e Innovación BFU2010-14901
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Protein misfolding ; Oxidative stress ; Amyloid-β-peptide ; Proteomic response
Published in:	Open biology, Vol. 5, issue 2 (Feb. 2015) , art. 140221, ISSN 2046-2441

DOI: 10.1098/rsob.140221
PMID: 25673330

9 p, 626.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles