Web of Science: 4 citations, Scopus: 5 citations, Google Scholar: citations,
Proteome response at the edge of protein aggregation
Sanchez de Groot, Natalia (MRC Laboratory of Molecular Biology)
Gomes, Ricardo A. (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier)
Villar Pique, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research)
Madan Babu, M. (MRC Laboratory of Molecular Biology)
Varela Coelho, Ana (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier)
Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)

Date: 2015
Abstract: Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison of two amyloid-β-peptide variants, mostly insoluble but differently recruited by the cell (inclusion body versus diffused), reveals small differences in cell fitness and proteome response. We suggest that the levels of oxidative stress act as a sensor to trigger protein recruitment into foci. Our data support a common cytoplasmic response being able to discern and react to the specific properties of polypeptides.
Note: Número d'acord de subvenció EC/FP7/299105
Note: Número d'acord de subvenció MINECO/BFU2013-44763
Note: Número d'acord de subvenció MICINN/AIB2010PT-00110
Note: Número d'acord de subvenció MICINN/BFU2010-14901
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Protein misfolding ; Oxidative stress ; Amyloid-β-peptide ; Proteomic response
Published in: Open biology, Vol. 5, issue 2 (Feb. 2015) , art. 140221, ISSN 2046-2441

PMID: 25673330
DOI: 10.1098/rsob.140221


9 p, 626.3 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-31, last modified 2019-03-23



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