2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich)
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy))
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich)
Brendel, Matthias (Ludwig-Maximilians-University Munich)
Rominger, Axel (Ludwig-Maximilians-University Munich)
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau)
Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau)
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE))
Traschütz, Andreas (Universitätsklinikum Bonn)
Heneka, Michael (Universitätsklinikum Bonn)
Struyfs, Hanne (University Hospital Antwerp (Bèlgica))
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica))
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge)
Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge)
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit))
Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences)
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology)
Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology)
Ewers, Michael (Ludwig-Maximilians-University Munich)
Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). In this cross-sectional multicenter study, we investigated whether levels of 2 are changed during the clinical course of , and in cognitively normal individuals with suspected non- pathology (). 2 levels were higher in mild cognitive impairment due to than in all other groups and controls. individuals also had significantly increased 2 compared to controls. Moreover, increased 2 levels were associated with higher total tau and phospho-tau, which are markers of neuronal degeneration and tau pathology. Our data demonstrate that 2 levels are increased in the early symptomatic phase of , probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.
Grants:	European Commission P7-2007-2013
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; Biomarkers ; Microglia ; Neurodegeneration ; TREM2 ; Biomarkers & Diagnostic Imaging ; Neuroscience
Published in:	EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476, ISSN 1757-4684

DOI: 10.15252/emmm.201506123
PMID: 26941262

11 p, 519.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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