Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Degenhardt, Frauke ![ORCID Identifier](/img/uab/orcid.ico)
(Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Ellinghaus, David ![ORCID Identifier](/img/uab/orcid.ico)
(Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca))
Juzenas, Simonas (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Lerga Jaso, Jon ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Wendorff, Mareike (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Maya-Miles, Douglas ![ORCID Identifier](/img/uab/orcid.ico)
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Uellendahl-Werth, Florian (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
ElAbd, Hesham (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Rühlemann, Malte C. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Arora, Jatin (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard (Cambridge, Estats Units))
Özer, Onur (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya))
Lenning, Ole Bernt (Stavanger University Hospital (Stavanger, Noruega))
Myhre, Ronny (Division of Health Data and Digitalization, Department of Genetics and Bioinformatics (HDGB). Norwegian Institute of Public Health (Oslo, Noruega))
Vadla, May Sissel (Randaberg Municipality (Stavanger, Noruega))
Wacker, Eike M. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Wienbrandt, Lars
(Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Blandino Ortiz, Aaron
(Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. University of Alcalá (Madrid))
de Salazar, Adolfo
(Instituto de Investigación Biosanitaria. Hospital Universitario Clínico San Cecilio (Granada, Andalusia))
Garrido Chercoles, Adolfo (Servicio Vasco de Salud de Osakidetza. Organización Sanitaria Integrada Donostialdea (Sant Sebastià, País Basc))
Palom, Adriana
(Hospital Universitari Vall d'Hebron)
Ruiz, Agustín
(Universitat Internacional de Catalunya)
Garcia-Fernandez, Alba-Estela
(Hospital Universitari Vall d'Hebron)
Blanco-Grau, Albert
(Hospital Universitari Vall d'Hebron)
Mantovani, Alberto (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Zanella, Alberto (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Holten, Aleksander Rygh (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Mayer, Alena (Charité - Universitätsmedizin Berlin)
Bandera, Alessandra (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Cherubini, Alessandro (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Protti, Alessandro
(IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Aghemo, Alessio (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Gerussi, Alessio (European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia))
Ramirez, Alfredo
(Uniklinik Köln (Colònia, Alemanya))
Braun, Alice
(Charité - Universitätsmedizin Berlin)
Nebel, Almut
Barreira-Diaz, Ana
(Hospital Universitari Vall d'Hebron)
Lleo, Ana (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Teles, Ana (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya))
Kildal, Anders Benjamin
(University Hospital of North Norway (Tromsø, Noruega))
Biondi, Andrea (Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia))
Caballero, Andrea
(Laboratorio de Análisis Dr. Echevarne (Barcelona))
Ganna, Andrea
(Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia))
Gori, Andrea (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Glück, Andreas (Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya))
Lind, Andreas (Oslo University Hospital (Olso, Noruega))
Tanck, Anja (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Hinney, Anke (University Hospital Essen. University of Duisburg-Essen (Essen, Alemanya))
Carreras Nolla, Anna
(Institut Germans Trias i Pujol)
Fracanzani, Anna Ludovica (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Peschuck, Anna (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Cavallero, Annalisa (Laboratory of Microbiology. San Gerardo Hospital (Monza, Itàlia))
Dyrhol-Riise, Anne Ma (Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Ruello, Antonella (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia))
Julià Cano, Antonio ![ORCID Identifier](/img/uab/orcid.ico)
Muscatello, Antonio (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Pesenti, Antonio
(University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Voza, Antonio (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Rando-Segura, Ariadna
(Hospital Universitari Vall d'Hebron)
Solier, Aurora (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid))
Schmidt, Axel (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Cortés, Beatriz
(Institut Germans Trias i Pujol)
Mateos, Beatriz (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Nafria-Jimenez, Beatriz
(Servicio Vasco de Salud de Osakidetza. Organización Sanitaria Integrada Donostialdea (Sant Sebastià, País Basc))
Schaefer, Benedikt (Medical University of Innsbruck (Innsbruck, Àustria))
Jensen, Björn (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya))
Bellinghausen, Carla (University Hospital. Goethe University (Frankfurt am Main, Alemanya))
Maj, Carlo (Institute of Genomic Statistics and Bioinformatics. University Hospital Bonn (Bonn, Alemanya))
Ferrando, Carlos
(Hospital Clínic i Provincial de Barcelona)
de la Horra, Carmen (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Quereda, Carmen (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Skurk, Carsten (Charité - Universitätsmedizin Berlin)
Thibeault, Charlotte (Charité - Universitätsmedizin Berlin)
Scollo, Chiara (San Gerardo Hospital (Monzo, Itàlia))
Herr, Christian (University Hospital Saarland (Homburg, Alemanya))
Spinner, Christoph D.
(University Hospital rechts der Isar. Technical University of Munich (Munich, Alemanya))
Gassner, Christoph (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Lange, Christoph (University of Lübeck (Lübeck, Alemanya))
Hu, Cinzia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Paccapelo, Cinzia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Lehmann, Clara (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya))
Angelini, Claudio (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Cappadona, Claudio (Humanitas University (Milà, Itàlia))
Azuure, Clinton (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya))
Bianco, Cristiana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Cea López, Cristina
(Hospital Universitari Vall d'Hebron)
Sancho, Cristina (Hospital de Basurto (Bilbao, Biscaia))
Hoff, Dag Arne Lihaug (Norwegian University of Science and Technology (Trondheim, Noruega))
Galimberti, Daniela
(University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Prati, Daniele
(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Haschka, David (Medical University of Innsbruck (Innsbruck, Àustria))
Jiménez Jiménez, David
(Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid))
Pestaña, David (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Toapanta, David (Hospital Clínic i Provincial de Barcelona)
Muñíz Díaz, Eduardo (Universitat Autònoma de Barcelona)
Azzolini, Elena (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Sandoval, Elena
(Hospital Clínic i Provincial de Barcelona)
Binatti, Eleonora (European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia))
Scarpini, Elio
(University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Helbig, Elisa T. (Charité - Universitätsmedizin Berlin)
Casalone, Elisabetta (Università degli Studi di Torino (Turin, Itàlia))
Urrechaga, Eloisa (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc))
Paraboschi, Elvezia Maria
(IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Pontali, Emanuele
(Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia))
Reverter, Enric
(Hospital Clínic i Provincial de Barcelona)
Calderón, Enrique J
(Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Navas, Enrique
(Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Solligård, Erik (Geminicenter for Sepsis Research. Institute of Circulation and Medical Imaging. Norwegian Univesity of Science and Technology (Trondheim, Noruega))
Contro, Ernesto (San Gerardo Hospital (Monza, Itàlia))
Arana-Arri, Eunate (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc))
Aziz, Fátima (Hospital Clínic i Provincial de Barcelona)
Garcia, Federico (Instituto de Investigación Biosanitaria. Hospital Universitario Clínico San Cecilio (Granada, Andalusia))
García Sánchez, Félix
(Centro de Transfusión (Madrid))
Ceriotti, Ferruccio (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Martinelli-Boneschi, Filippo (Dino Ferrari Center. University of Milan (Milà, Itàlia))
Peyvandi, Flora (University of Milan (Milà, Itàlia))
Kurth, Florian (Charité - Universitätsmedizin Berlin)
Blasi, Francesco
(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Malvestiti, Francesco (University of Milan (Milà, Itàlia))
Medrano, Francisco J. (Instituto de Biomedicina de Sevilla. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (Madrid))
Mesonero, Francisco
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Rodríguez Frías, Francisco
(Hospital Universitari Vall d'Hebron)
Hanses, Frank (University Hospital Regensburg (Regensburg, Alemanya))
Müller, Fredrik (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Hemmrich-Stanisak, Georg (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Bellani, Giacomo (San Gerardo Hospital (Monza, Itàlia))
Grasselli, Giacomo (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Pezzoli, Gianni (Fondazione Grigioni per il Morbo di Parkinson and Parkinson Institute. ASST Gaetano Pini-CTO (Milà, Itàlia))
Costantino, Giorgio (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Albano, Giovanni (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia))
Cardamone, Giulia (Humanitas University (Milà, Itàlia))
Bellelli, Giuseppe (University of Milano-Bicocca (Milà, Itàlia))
Citerio, Giuseppe
(University of Milano-Bicocca (Milà, Itàlia))
Foti, Giuseppe (San Gerardo Hospital (Monza, Itàlia))
Lamorte, Giuseppe (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Matullo, Giuseppe (Università degli Studi di Torino (Turin, Itàlia))
Baselli, Guido (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Kurihara, Hayato (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Neb, Holger (University Hospital Frankfurt (Frankfurt am Main, Alemanya))
My, Ilaria
Kurth, Ingo (Institute of Human Genetics. RWTH Aachen University (Aachen, Alemanya))
Hernández, Isabel
(Universitat Internacional de Catalunya)
Pink, Isabell (Hannover Medical School (Hannover, Alemanya))
De Rojas, Itziar
(Universitat Internacional de Catalunya)
Galván-Femenía, Iván
(Institut Germans Trias i Pujol)
Holter, Jan Cato (Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Afset, Jan Egil (Hospital de Basurto (Bilbao, Biscaia))
Heyckendorf, Jan
(University of Lübeck (Lübeck, Alemanya))
Kässens, Jan (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Damås, Jan Kristian (St. Olavs Hospital. Trondheim University Hospital (Trondheim, Noruega))
Rybniker, Jan (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya))
Altmüller, Janine
(Cologne Center for Genomics. University of Cologne (Colònia, Alemanya))
Ampuero, Javier
(Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Martín, Javier
(Instituto de Parasitología y Biomedicina "López-Neyra")
Erdmann, Jeanette
(Institute for Cardiogenetics. University of Lübeck (Lübeck, Alemanya))
Banales, Jesus
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Badia, Joan Ramon (Hospital Clínic i Provincial de Barcelona)
Dopazo, Joaquín
(Instituto de Biomedicina de Sevilla (Sevilla, Andalusia))
Schneider, Jochen (University Hospital Saarland (Homburg, Alemanya))
Bergan, Jonas
(Ostfold Hospital Trust (Gralum, Noruega))
Barretina, Jordi
(Institut Germans Trias i Pujol)
Walter, Jörn (Saarland University (Saarbrücken, Alemanya))
Hernández Quero, José (Instituto de Investigación Biosanitaria de Granada)
Goikoetxea, Josune (Instituto de Investigación Sanitaria Biocruces Bizkaia (Biscaia, País Basc))
Delgado, Juan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Guerrero, Juan M. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Fazaal, Julia (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Kraft, Julia
(Charité - Universitätsmedizin Berlin)
Schröder, Julia (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Risnes, Kari (Norwegian University of Science and Technology (Trondheim, Noruega))
Banasik, Karina
(Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca))
Müller, Karl Erik (Drammen Hospital. Vestre Viken Hospital Trust (Drammen, Noruega))
Gaede, Karoline I. (Research Center Borstel. BioMaterialBank Nord (Borstel, Alemanya))
Garcia-Etxebarria, Koldo (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Tonby, Kristian (Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Heggelund, Lars (Drammen Hospital. Vestre Viken Hospital Trust (Drammen, Noruega))
Izquierdo-Sanchez, Laura (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Bettini, Laura Rachele
(Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia))
Sumoy, Lauro
(Institut Germans Trias i Pujol)
Sander, Leif Erik (Charité - Universitätsmedizin Berlin)
Lippert, Lena J. (Charité - Universitätsmedizin Berlin)
Terranova, Leonardo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Nkambule, Lindokuhle (Massachusetts General Hospital (Boston))
Knopp, Lisa (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya))
Gustad, Lise Tuset (Geminicenter for Sepsis Research. Institute of Circulation and Medical Imaging. Norwegian Univesity of Science and Technology (Trondheim, Noruega))
Garbarino, Lucia (Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia))
Santoro, Luigi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Téllez, Luis
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Roade, Luisa
(Hospital Universitari Vall d'Hebron)
Ostadreza, Mahnoosh (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Intxausti, Maider (Hospital de Basurto (Bilbao, Biscaia))
Kogevinas, M.
(Institut Hospital del Mar d'Investigacions Mèdiques)
Riveiro Barciela, Mar
(Hospital Universitari Vall d'Hebron)
Berger, Marc M. (University Hospital Essen. University Duisburg-Essen (Essen, Alemanya))
Schaefer, Marco (Stefan-Morsch-Stiftung (Birkenfeld, Alemanya))
Niemi, Mari E. K. (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia))
Gutiérrez-Stampa, María Ángeles (OSI Donostialdea. Biodonostia Instituto de Investigación Sanitaria (Sant Sebastià, País Basc))
Carrabba, Maria (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Figuera Basso, Maria E. (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Valsecchi, Maria Grazia (Center of Bioinformatics. Biostatistics and Bioimaging. University of Milano-Bicocca (Milà, Itàlia))
Hernandez-Tejero, María (Hospital Clínic i Provincial de Barcelona)
Vehreschild, Maria J. G. T. (University Hospital Frankfurt & Goethe University Frankfurt (Frankfurt am Main, Alemanya))
Manunta, Maria
(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Acosta-Herrera, Marialbert
(Institute of Parasitology and Biomedicine Lopez-Neyra (Granada, Andalusia))
D'Angiò, Mariella (Centro Tettamanti-European Reference Network. PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale (San Gerardo, Itàlia))
Baldini, Marina (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Cazzaniga, Marina Elena
(University of Milano-Bicocca (Monza, Itàlia))
Grimsrud, Marit M. (Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Cornberg, Markus
(Hannover Medical School (Hannover, Alemanya))
Nöthen, Markus M.
(Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Marquié, Marta
(Universitat Internacional de Catalunya)
Castoldi, Massimo (Humanitas Gavazzeni-Castelli (Bergamo, Itàlia))
Cordioli, Mattia
(Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia))
Cecconi, Maurizio
(IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
D'Amato, Mauro
Augustin, Max (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya))
Tomasi, Melissa (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Boada, Mercè
(Universitat Internacional de Catalunya)
Dreher, Michael (University Hospital Aachen (Alemanya))
Seilmaier, Michael J. (Munich Clinic Schwabing. Academic Teaching Hospital. Ludwig-Maximilians-University (Munich, Alemanya))
Joannidis, Michael
(Medical University Innsbruck (Innsbruck, Alemanya))
Wittig, Michael (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Mazzocco, Michela (Ente Ospedaliero Ospedali Galliera (Gènova, Itàlia))
Ciccarelli, Michele
(Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Rodríguez-Gandía, Miguel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Bocciolone, Monica (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Miozzo, Monica (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Imaz Ayo, Natale (Instituto de Investigación Sanitaria Biobizkaia (Barakaldo, País Basc))
Blay, Natalia
(Institut Germans Trias i Pujol)
Chueca, Natalia
(Hospital Universitario San Cecilio (Granada))
Montano, Nicola (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Braun, Nicole (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Ludwig, Nicole
(Center of Human and Molecular Biology. University Hospital Saarland (Homburg/Saar, Alemanya))
Marx, Nikolaus (RWTH Aachen University Hospital (Aachen, Alemanya))
Martínez, Nilda (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Cornely, Oliver A
(Uniklinik Köln (Colònia, Alemanya))
Witzke, Oliver
Palmieri, Orazio
Faverio, Paola
(University of Milano-Bicocca (Milà, Itàlia))
Preatoni, Paoletta (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Bonfanti, Paolo
(University of Milano-Bicocca (Milà, Itàlia))
Omodei, Paolo (Humanitas Clinical and Research Center. Istituto di ricovero e cura a carattere scientifico(IRCCS)(Milà, Itàlia))
Tentorio, Paolo
Castro, Pedro (Hospital Clínic i Provincial de Barcelona)
Rodrigues, Pedro M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
España, PP.
(Hospital de Galdakao (Galdakao, Biscaia))
Hoffmann, Per
(Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Rosenstiel, Philip
(Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Schommers, Philipp (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya))
Suwalski, Phillip (Charité - Universitätsmedizin Berlin)
de Pablo, Raúl (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. University of Alcalá (Madrid))
Ferrer, Ricard
(Hospital Universitari Vall d'Hebron)
Bals, Robert (University Hospital Saarland (Homburg, Alemanya))
Gualtierotti, Roberta (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Gallego-Durán, Rocío (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Nieto, Rosa (Hospital Universitario Ramón y Cajal. Instituto Ramón y Cajal de Investigación Sanitaria. Universidad de Alcalá (Madrid))
Carpani, Rossana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Morilla, Rubén (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Badalamenti, Salvatore
Haider, Sammra
Ciesek, Sandra
May, Sandra (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Bombace, Sara (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Marsal, Sara
(Hospital Universitari Vall d'Hebron)
Pigazzini, Sara (Institute for Molecular Medicine Finland. University of Helsinki (Helsinki, Finlàndia))
Klein, Sebastian (Medical University Innsbruck (Innsbruck, Alemanya))
Pelusi, Serena (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Wilfling, Sibylle (Zentrum für Humangenetik Regensburg (Regensburg, Alemanya))
Bosari, Silvano (University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Volland, Sonja
Brunak, Søren
(Novo Nordisk Foundation Center for Protein Research. University of Copenhagen (Copenhagen, Dinamarca))
Raychaudhuri, Soumya
(Program in Medical and Population Genetics. Broad Institute of MIT and Harvard (Cambridge, Estats Units))
Schreiber, Stefan (Institute of Clinical Molecular Biology. Christian-Albrechts-University. Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya))
Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Aliberti, Stefano
(IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Ripke, Stephan
(Charité - Universitätsmedizin Berlin)
Dudman, Susanne
(Oslo University Hospital. Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Wesse, Tanja (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Zheng, Tenghao
Bahmer, Thomas (Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya))
Eggermann, Thomas (Institute of Human Genetics. RWTH Aachen University (Aachen, Alemanya))
Illig, Thomas
Brenner, Thorsten (University Hospital Essen. University Duisburg-Essen (Essen, Alemanya))
Pumarola Suñé, Tomàs
(Hospital Universitari Vall d'Hebron)
Feldt, Torsten (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya))
Folseraas, Trine (Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Gonzalez Cejudo, Trinidad
Landmesser, Ulf
Protzer, Ulrike ![ORCID Identifier](/img/uab/orcid.ico)
Hehr, Ute
Rimoldi, Valeria (Humanitas University (Milà, Itàlia))
Monzani, Valter (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Skogen, Vegard (University Hospital of North Norway (Tromsø, Noruega))
Keitel, Verena (University Hospital Duesseldorf. Medical Faculty Heinrich Heine University (Duesseldorf, Alemanya))
Kopfnagel, Verena
Friaza, Vicente
(Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Andrade, Victor (Faculty of Medicine and University Hospital Cologne. University of Cologne (Colònia, Alemanya))
Moreno Aguado, Víctor
(Institut d'Investigació Biomèdica de Bellvitge)
Morros, Rosa ![ORCID Identifier](/img/uab/orcid.ico)
Albrecht, Wolfgang (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Peter, Wolfgang (Stefan-Morsch-Stiftung (Birkenfeld, Alemanya))
Poller, Wolfgang (Charité - Universitätsmedizin Berlin)
Farré, Xavier
(Institut Germans Trias i Pujol)
Yi, Xiaoli (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Wang, Xiaomin (Charité - Universitätsmedizin Berlin)
Khodamoradi, Yascha
(University Hospital Frankfurt & Goethe University Frankfurt (Frankfurt am Main, Alemanya))
Karadeniz, Zehra (Charité - Universitätsmedizin Berlin)
Latiano, Anna
Goerg, Siegfried (Institute of Transfusionsmedicine. University Hospital Schleswig-Holstein (Kiel, Alemanya))
Bacher, Petra (Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Koehler, Philipp
(Uniklinik Köln (Colònia, Alemanya))
Tran, Florian (Institute of Clinical Molecular Biology. Christian-Albrechts-University. Klinik für Innere Medizin I. Universitätsklinikum Schleswig-Holstein (Kiel, Alemanya))
Zoller, Heinz
(Medical University of Innsbruck (Innsbruck, Àustria))
Schulte, Eva C ![ORCID Identifier](/img/uab/orcid.ico)
Heidecker, Bettina (Charité - Universitätsmedizin Berlin)
Ludwig, Kerstin U.
(Institute of Human Genetics. University Hospital Bonn (Bonn, Alemanya))
Fernández, Javier
(Hospital Clínic i Provincial de Barcelona)
Romero-Gómez, Manuel
(Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Albillos, Agustín
(Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas. Instituto de Salud Carlos III (Madrid))
Invernizzi, Pietro
(European Reference Network on Hepatological Diseases. San Gerardo Hospital (Monza, Itàlia))
Buti, Maria
(Hospital Universitari Vall d'Hebron)
Duga, Stefano (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
Bujanda, Luis
(Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Madrid))
Hov, Johannes R.
(Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Lenz, Tobias L. (Research Group for Evolutionary Immunogenomics. Max Planck Institute for Evolutionary Biology (Plön, Alemanya))
Asselta, Rosanna (IRCCS Humanitas Research Hospital. Humanitas University (Milà, Itàlia))
de Cid, Rafael
(Institut Germans Trias i Pujol)
Valenti, Luca
(University of Milan. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Karlsen, Tom H. (Institute of Clinical Medicine. University of Oslo (Olso, Noruega))
Cáceres Aguilar, Mario
(Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Franke, Andre
(Institute of Clinical Molecular Biology. Christian-Albrechts-University (Kiel, Alemanya))
Date: |
2022 |
Abstract: |
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21. 31 to a ~0. 9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13. 33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. |
Grants: |
Instituto de Salud Carlos III PI17/00535 Instituto de Salud Carlos III PI19/00589 Ministerio de Economía y Competitividad PI16/01842 Instituto de Salud Carlos III PI19/01404 Agencia Estatal de Investigación PID2019-107836RB-I00 Ministerio de Ciencia e Innovación ADE10/00026
|
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by-nc.ico) |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Published in: |
Human Molecular Genetics, Vol. 31 (july 2022) , p. 3945-3966, ISSN 1460-2083 |
DOI: 10.1093/hmg/ddac158
PMID: 35848942
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Record created 2022-12-08, last modified 2024-07-20