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Articles 32 records found  previous11 - 20nextend  jump to record: Search took 0.02 seconds. 
11.
5 p, 264.8 KB Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease / Perea, Juan R. (Centro de Biología Molecular Severo Ochoa) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Ávila, Jesús (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bolós, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. [...]
2018 - 10.3389/fnins.2018.00609
Frontiers in Neuroscience, Vol. 12 (september 2018)  
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12.
18 p, 4.6 MB Effect of Topical Administration of Somatostatin on Retinal Inflammation and Neurodegeneration in an Experimental Model of Diabetes / Hernández, Cristina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Arroba, Ana I (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ; Bogdanov, Patricia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Ramos, Hugo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Simó-Servat, Olga (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Simó Canonge, Rafael (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Valverde, Angela M. (Instituto de Investigaciones Biomédicas "Alberto Sols") ; Universitat Autònoma de Barcelona
Somatostatin (SST) is a neuroprotective peptide but little is known regarding the potential role of its anti-inflammatory effects on retinal neuroprotection. In a previous study, we provided the first evidence that topical (eye drops) administration of SST prevents retinal neurodegeneration in streptozotocin (STZ)-induced diabetic rats. [...]
2020 - 10.3390/jcm9082579
Journal of clinical medicine, Vol. 9 (august 2020)  
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13.
19 p, 1.3 MB Immune system-related changes in preclinical GL261 glioblastoma under TMZ treatment : Explaining MRSI-based nosological imaging findings with RT-PCR analyses / Calero-Perez, Pilar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Wu, Shuang (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy. Previous work suggests that magnetic resonance spectroscopic imaging (MRSI) could act as a biomarker of efficient immune system attack onto GB, presenting oscillatory changes. [...]
2021 - 10.3390/cancers13112663
Cancers, Vol. 13, Issue 11 (June 2021) , art. 2663  
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14.
16 p, 2.7 MB Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease / Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Casanovas, Mireia (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Lillo, Alejandro (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. [...]
2020 - 10.3390/cells9051075
Cells, Vol. 9 Núm. 5 (april 2020)  
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15.
19 p, 6.1 MB TREM2 expression in the brain and biological fluids in prion diseases / Diaz-Lucena, Daniela (Institut d'Investigació Biomèdica de Bellvitge) ; Kruse, Niels (University Medical Center Göttingen. Institute of Neuropathology) ; Thüne, Katrin (University Medical Center Göttingen. Department of Neurology) ; Schmitz, Matthias (German Center for Neurodegenerative Diseases) ; Villar-Piqué, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; da Cunha, Jose Eriton Gomes (Universidade Federal de Pernambuco. Keizo Asami Laboratory) ; Hermann, Peter (University Medical Center Göttingen. Department of Neurology) ; López-Pérez, Óscar (Institut d'Investigació Biomèdica de Bellvitge) ; Andrés-Benito, P (Institut d'Investigació Biomèdica de Bellvitge) ; Ladogana, Anna (Istituto Superiore Di Sanità. Department of Neurosciences) ; Calero, Miguel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries) ; Riggert, Joachim (University Medical School. Department of Transfusion Medicine) ; Pineau, Hailey (University of Alberta. Department of Medicine-Division of Neurology) ; Sim, Valerie (University of Alberta. Department of Medicine-Division of Neurology) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Blennow, Kaj (Sahlgrenska University Hospital. Clinical Neurochemistry Laboratory) ; Del Rio, Jose Antonio (Universitat de Barcelona. Institut de Neurociències) ; Marín-Moreno, Alba (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Espinosa, Juan Carlos (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Torres, Juan María (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mollenhauer, Brit (University Medical Centre Göttingen. Department of Neurology) ; Ferrer, Isidro (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Zerr, Inga (German Center for Neurodegenerative Diseases) ; Llorens, Franc (University Medical Center Göttingen. Department of Neurology)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases. [...]
2021 - 10.1007/s00401-021-02296-1
Acta Neuropathologica, Vol. 141 (april 2021) , p. 841-859  
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16.
20 p, 15.9 MB Three-dimensional vascular microenvironment landscape in human glioblastoma / Cribaro, George Paul (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Saavedra-López, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Romarate, Leire (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Mitxitorena, Izaskun (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Díaz, Laura R. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Casanova, Paola (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Roig-Martínez, Meritxell (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gallego, José Maria (Hospital General Universitario de Valencia) ; Perez-Vallés, Ana (Hospital General Universitario de Valencia) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this deadly tumor. [...]
2021 - 10.1186/s40478-020-01115-0
Acta neuropathologica communications, Vol. 9 (february 2021)  
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17.
22 p, 6.8 MB Chronic exposure to IL-6 induces a desensitized phenotype of the microglia / Recasens, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Almolda Ardid, Beatriz (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pérez-Clausell, Jeús (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Campbell, Iain L. (University of Sydney. School of Life and Environmental Sciences and Charles Perkins Centre) ; González, Berta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Castellano López, Bernardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and particularly the microenvironment generated by the lesion. [...]
2021 - 10.1186/s12974-020-02063-1
Journal of neuroinflammation, Vol. 18 (january 2021)  
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18.
20 p, 2.4 MB Phagocytic glioblastoma-associated microglia and macrophages populate invading pseudopalisades / Saavedra-López, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Roig-Martínez, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cribaro, George Paul (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Casanova, Paola (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gallego, José Maria (Hospital General Universitario de Valencia) ; Perez-Vallés, Ana (Hospital General Universitario de Valencia) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Hypoxic pseudopalisades are a pathological hallmark of human glioblastoma, which is linked to tumour malignancy and aggressiveness. Yet, their function and role in the tumour development have scarcely been explored. [...]
2019 - 10.1093/braincomms/fcz043
Brain Communications, Vol. 2 (december 2019)  
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19.
9 p, 1.0 MB Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study / Berasategui, Barbara (Instituto de Investigación Sanitaria Biocruces Bizkaia) ; Fonollosa, Alex (Instituto de Investigación Sanitaria Biocruces Bizkaia) ; Artaraz, Joseba (Instituto de Investigación Sanitaria Biocruces Bizkaia) ; Ruiz Arruza, Ioana (Instituto de Investigación Sanitaria Biocruces Bizkaia) ; Ríos, Jose (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Matas, Jessica (Hospital Clínic i Provincial de Barcelona) ; Llorenç, Victor (Hospital Clínic i Provincial de Barcelona) ; Diaz Valle, David (Hospital Clínico San Carlos (Madrid)) ; Sastre Ibañez, Marina (Hospital Clínico San Carlos (Madrid)) ; Arriola Villalobos, Pedro (Hospital Clínico San Carlos (Madrid)) ; Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona)
Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. [...]
2018 - 10.1186/s12886-018-0848-5
BMC ophthalmology, Vol. 18 (july 2018)  
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20.
19 p, 13.2 MB Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death / Rodriguez-Perez, Ana I. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Sucunza, Diego (University of Navarra. Neurosciences Division, Centro de Investigación Médica Aplicada) ; Pedrosa, Maria A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Garrido-Gil, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ; Lanciego, Jose L. (University of Navarra. Neurosciences Division, Centro de Investigación Médica Aplicada) ; Labandeira-Garcia, Jose L. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
The loss of dopaminergic neurons and α-synuclein accumulation are major hallmarks of Parkinson's disease (PD), and it has been suggested that a major mechanism of α-synuclein toxicity is microglial activation. [...]
2018 - 10.1007/s13311-018-0646-z
Neurotherapeutics, Vol. 15 (july 2018) , p. 1063-1081  
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