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10 p, 701.1 KB |
Circulating non-coding RNAs in biomarker-guided cardiovascular therapy : A novel tool for personalized medicine?
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Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vea, Ángela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bär, C. (Hannover Medical School) ;
Fiedler, J. (Hannover Medical School) ;
Couch, L.S. (Imperial College London) ;
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Thum, T. (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. [...]
2019 -  10.1093/eurheartj/ehy234
European heart journal, Vol. 40 Núm. 20 (january 2019) , p. 1643-1650
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14 p, 1.8 MB |
Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals : The REGICOR study
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Degano, Irene R (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Camps-Vilaró, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Subirana, Isaac (Institut Hospital del Mar d'Investigacions Mèdiques) ;
García-Mateo, N. (Universidad de Valladolid and Consejo Superior de Investigaciones Científicas (CSIC)) ;
Cidad, P. (Universidad de Valladolid and Consejo Superior de Investigaciones Científicas (CSIC)) ;
Muñoz Aguayo, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puigdecanet, E. (Universitat de Vic - Universitat Central de Catalunya) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vila-Domènech, Joan Salvador (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crepaldi, Felipe Mingorance (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ;
Llorente-Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-García, M.T. (Universidad de Valladolid and Consejo Superior de Investigaciones Científicas (CSIC)) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fitó, Montserrat (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Marrugat, Jaume 1954- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. [...]
2020 - 10.3390/jcm9051402
Journal of clinical medicine, Vol. 9 Núm. 5 (may 2020) , p. Article
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3.
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20 p, 1.3 MB |
Early prognostic performance of miR155-5p monitoring for the risk of rejection : Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
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Quintairos, Luis (Hospital Clínic i Provincial de Barcelona) ;
Colom, Helena (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Millan, Olga (Instituto de Salud Carlos III) ;
Fortuna, Virginia (Hospital Clínic i Provincial de Barcelona) ;
Espinosa, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Guirado, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Budde, K (Charité - Universitätsmedizin Berlin) ;
Sommerer, Claudia (Heidelberg University Hospital (Alemanya)) ;
Lizana, Ana (Hospital Clínic i Provincial de Barcelona) ;
Lopez-Pua, Yolanda (Hospital Clínic i Provincial de Barcelona) ;
Brunet, Mercè (Instituto de Salud Carlos III)
Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. [...]
2021 - 10.1371/journal.pone.0245880
PloS one, Vol. 16 Núm. 1 January (january 2021) , p. e0245880
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4.
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14 p, 3.9 MB |
Combined analysis of miR-200 family and its significance for breast cancer
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Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Dama, Elisa (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Rendina, Michelina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Morritti, Maria Grazia (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Melocchi, Valentina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Castelvetere, Marina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Valori, Vanna Maria (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Ravaioli, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Ciuffreda, Luigi (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Fazio, Vito Michele (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bianchi, Fabrizio (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza)
While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. [...]
2021 - 10.1038/s41598-021-82286-1
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 2980
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5.
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17 p, 1.3 MB |
The transcribed ultraconserved region uc.160+ enhances processing and A-to-I editing of the miR-376 cluster : hypermethylation improves glioma prognosis
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Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez Castillo, Anaís (Maastricht University Medical Center) ;
Mora Martínez, Carlos (University of Helsinki) ;
Setién, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Siqueira, E (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Transcribed ultraconserved regions (T-UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T-UCRs as regulators of gene expression has been proposed, their functions remain largely unknown. [...]
2022 - 10.1002/1878-0261.13121
Molecular Oncology, Vol. 16 Núm. 3 (february 2022) , p. 648-664
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13 p, 1.6 MB |
Resistance to PI3Kδ inhibitors in marginal zone lymphoma can be reverted by targeting the IL-6/PDGFRA axis
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Arribas, Alberto J (SIB Swiss Institute of Bioinformatics) ;
Napoli, Sara (Università della Svizzera Italiana) ;
Cascione, Luciano (SIB Swiss Institute of Bioinformatics) ;
Sartori, Giulio (Università della Svizzera Italiana) ;
Barnabei, Laura (Università della Svizzera Italiana) ;
Gaudio, Eugenio (Università della Svizzera Italiana) ;
Tarantelli, Chiara (Università della Svizzera Italiana) ;
Mensah, Afua Adjeiwaa (Università della Svizzera Italiana) ;
Spriano, Filippo (Università della Svizzera Italiana) ;
Zucchetto, Antonella (Centro di Riferimento Oncologico di Aviano) ;
Rossi, Francesca M (Centro di Riferimento Oncologico di Aviano) ;
Rinaldi, Andrea (Università della Svizzera Italiana) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jovic, Sandra (Università della Svizzera italiana) ;
Bordone-Pittau, Roberta (Oncology Institute of Southern Switzerland) ;
Di Veroli, Alessandra (University of Perugia) ;
Stathis, Anastasios (Università della Svizzera Italiana) ;
Cruciani, Gabriele (University of Perugia) ;
Stussi, Georg (Oncology Institute of Southern Switzerland) ;
Gattei, Valter (Centro di Riferimento Oncologico di Aviano) ;
Brown, Jennifer R (Harvard Medical School) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zucca, Emanuele (Oncology Institute of Southern Switzerland) ;
Rossi, Davide (Oncology Institute of Southern Switzerland) ;
Bertoni, Francesco (Oncology Institute of Southern Switzerland) ;
Universitat Autònoma de Barcelona
PI3Kδ inhibitors are active in patients with lymphoid neoplasms and a first series of them have been approved for the treatment of multiple types of B-cell lymphoid tumors, including marginal zone lymphoma (MZL). [...]
2022 - 10.3324/haematol.2021.279957
Haematologica, Vol. 107 Núm. 11 (november 2022) , p. 2685-2697
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14 p, 2.9 MB |
Circulating microRNAs in Early Breast Cancer Patients and Its Association With Lymph Node Metastases
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Escuin i Borràs, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Mora, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
Bell, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Moral Duarte, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Arqueros, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
García-Valdecasas Vilanova, Bárbara (Institut d'Investigació Biomèdica Sant Pau) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Lerma Puertas, Enrique (Institut d'Investigació Biomèdica Sant Pau) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
MicroRNAs have emerged as important regulators of the metastatic process. In addition, circulating miRNAs appear to be surprisingly stable in peripheral blood making them ideal noninvasive biomarkers for disease diagnosis. [...]
2021 - 10.3389/fonc.2021.627811
Frontiers in Oncology, Vol. 11 (august 2021) , p. 627811
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14 p, 3.2 MB |
Micrornas as a suitable biomarker to detect the effects of long-term exposures to nanomaterials. Studies on tio2np and mwcnt
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Ballesteros Ribera, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vales, Gerard (Finnish Institute of Occupational Health) ;
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alaraby, Mohamed (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the present study analyzed a panel of 33 miRNAs related to the cell transformation process in BEAS-2B cells transformed by TiO2NP and long-term MWCNT exposure. [...]
2021 - 10.3390/nano11123458
Nanomaterials, Vol. 11, Issue 12 (December 2021) , art. 3458
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16 p, 1.1 MB |
Systemic profiles of micrornas, redox balance, and inflammation in lung cancer patients : influence of copd
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Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guitart, Maria (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Curull Serrano, Víctor (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sánchez-Font, Albert (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tang, Jun (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Admetlló, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques)
Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. [...]
2021 - 10.3390/biomedicines9101347
Biomedicines, Vol. 9 Núm. 10 (september 2021) , p. 1347
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12 p, 1.2 MB |
MicroRNA-1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer
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Escuin i Borràs, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Bell, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
Moral Duarte, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez, José Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Arqueros, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Lerma Puertas, Enrique (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Barnadas i Molins, Agustí (Centro de Investigación Biomédica en Red de Cáncer)
Evidence that microRNAs (miRNAs) regulate the various steps of metastasis is increasing. Several studies have looked at the miRNA expression profile in primary breast tumors but few have compared primary tumor and sentinel lymph node (SLN) metastasis. [...]
2020 - 10.3389/fgene.2020.562114
Frontiers in genetics, Vol. 11 (december 2020)
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