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1.
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65 p, 2.2 MB |
Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators
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Woloszynska, Magdalena (Ghent University) ;
Le Gall, Sabine (Ghent University) ;
Neyt, Pia (Ghent University) ;
Boccardi, Tommaso Matteo (Ghent University) ;
Grasser, Marion (University of Regensburg) ;
Längst, Gernot (University of Regensburg) ;
Aesaert, Stijn (Ghent University) ;
Coussens, Griet (Ghent University) ;
Dhondt, Stijn (Ghent University) ;
Van De Slijke, Eveline (Ghent University) ;
Bruno, Leonardo (Università della Calabria) ;
Fung Uceda, Jorge Alberto (Centre de Recerca en Agrigenòmica) ;
Mas, Paloma (Centre de Recerca en Agrigenòmica) ;
Van Montagu, Marc (Ghent University) ;
Inzé, Dirk (Ghent University) ;
Himanen, Kristiina (Ghent University) ;
De Jaeger, Geert (Ghent University) ;
Grasser, Klaus D. (University of Regensburg) ;
Van Lijsebettens, Mieke (Ghent University)
HISTONE MONOUBIQUITINATION1 (HUB1) and its paralog HUB2 act in a conserved heterotetrameric complex in the chromatin-mediated transcriptional modulation of developmental programs, such as flowering time, dormancy, and the circadian clock. [...]
2019 -  10.1073/pnas.1806541116
Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Num. 16 (April 2019) , p. 8060-8069
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2.
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10 p, 3.8 MB |
An atypical RNA silencing suppression strategy provides a snapshot of the evolution of sweet potato-infecting potyviruses
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Rodamilans, Bernardo (Centro Nacional de Biotecnología (Espanya)) ;
Valli, Adrián A. (Centro Nacional de Biotecnología (Espanya)) ;
Mingot, Ares (Centre de Recerca en Agrigenòmica) ;
San León, David (Centro Nacional de Biotecnología (Espanya)) ;
López-Moya, Juan José (Centre de Recerca en Agrigenòmica) ;
García, Juan Antonio (Centro Nacional de Biotecnología (Espanya))
Plant viruses usually encode proteins with RNA silencing suppression (RSS) activity to counteract plant defenses. In Potyvirus, the largest genus in the family Potyviridae, this role is taken over by the multifunctional HCPro, also involved in aphid transmission, polyprotein processing and virion formation. [...]
2018 - 10.1038/s41598-018-34358-y
Scientific reports, Vol. 8 (October 2018) , art. 15937
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3.
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12 p, 977.9 KB |
Role of AMPK signalling pathway during compensatory growth in pigs
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Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries) ;
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica) ;
González-Rodríguez, Olga (Institut de Recerca i Tecnologia Agroalimentàries) ;
Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica) ;
Pascual, Mariam (Institut de Recerca i Tecnologia Agroalimentàries) ;
González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ;
Panella Riera, Núria (Institut de Recerca i Tecnologia Agroalimentàries) ;
Díaz Reviriego, Isabel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Tibau, Joan (Institut de Recerca i Tecnologia Agroalimentàries) ;
Quintanilla Aguado, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Universitat Autònoma de Barcelona
Background: The molecular basis of compensatory growth in monogastric animals has not yet been fully explored. Herewith, in this study we aim to determine changes in the pig skeletal muscle transcriptome profile during compensatory growth following a feed restriction period. [...]
2018 - 10.1186/s12864-018-5071-5
BMC genomics, Vol. 19 (September 2018) , art. 682
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51 p, 4.9 MB |
Deep Sequencing Reveals Early Reprogramming of Arabidopsis Root Transcriptomes Upon Ralstonia solanacearum Infection
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Zhao, Cuizhu (Northwest A&F University. College of Agronomy) ;
Wang, Huijuan (Northwest A&F University. College of Agronomy) ;
Lu, Yao (Northwest A&F University. College of Agronomy) ;
Hu, Jinxue (Northwest A&F University. College of Agronomy) ;
Qu, Ling (Northwest A&F University. College of Agronomy) ;
Li, Zheqing (Northwest A&F University. College of Agronomy) ;
Wang, Dongdong (Northwest A&F University. College of Agronomy) ;
He, Yizhe (Northwest A&F University. College of Agronomy) ;
Valls, Marc (Centre de Recerca en Agrigenòmica) ;
Coll, Núria (Centre de Recerca en Agrigenòmica) ;
Chen, Qin (Northwest A&F University. College of Agronomy) ;
Lu, Haibin (Northwest A&F University. College of Agronomy)
2019 - 10.1094/MPMI-10-18-0268-R
Molecular plant-microbe interactions, Vol. 32, no. 7 (July 2019)
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6.
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15 p, 620.2 KB |
Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency
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Córdoba, Sarai (Centre de Recerca en Agrigenòmica) ;
Balcells Ortega, Ingrid (Centre de Recerca en Agrigenòmica) ;
Castelló, Anna (Centre de Recerca en Agrigenòmica) ;
Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria) ;
Noguera Jiménez, José Luis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Timoneda i Heredia, Oriol (Centre de Recerca en Agrigenòmica) ;
Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ;
Universitat Autònoma de Barcelona.
Departament de Genètica Animal
2015 0) and low (L, EBV 0) prolificacy phenotypes. For each sample, mRNA and small RNA libraries were RNA-sequenced, identifying 141 genes and 10 miRNAs differentially expressed between H and L groups. We selected four miRNAs based on their role in reproduction, and five genes displaying the highest differences and a positive mapping into known reproductive QTLs for RT-qPCR validation on the whole extreme population. Significant differences were validated for genes: PTGS2 (p = 0.03; H/L ratio = 3.50), PTHLH (p = 0.03; H/L ratio = 3.69), MMP8 (p = 0.01; H/L ratio = 4.41) and SCNN1G (p = 0.04; H/L ratio = 3.42). Although selected miRNAs showed similar expression levels between H and L groups, significant correlation was found between the expression level of ssc-miR-133a (p 0.01) and sscmiR-92a (p 0.01) and validated genes. These results provide a better understanding of the genetic architecture of prolificacy-related traits and embryo implantation failure in pigs. - 10.1038/srep14416
Scientific reports, Vol. 5 (October 2015) , art. 14416
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7.
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21 p, 6.7 MB |
Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM)
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Coccia, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Calleja Yagüe, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Planells Ferrer, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Sanuy, Blanca (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Sanz, Belen (Cell Division and Cancer Group. Spanish National Cancer Research Centre (CNIO)) ;
López Soriano, Joaquin (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Moubarak, Rana S. (Department of Pathology. NYU Langone Medical Center) ;
Munell Casadesus, Francina (Vall d'Hebron Institut de Recerca(VHIR)) ;
Barneda Zahonero, Bruna (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Comella i Carnicé, Joan Xavier 1963- (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular) ;
Pérez García, María José (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i Biologia Molecular)
Fas Apoptosis Inhibitory Molecule (FAIM) is an evolutionarily highly conserved death receptor antagonist, widely expressed and known to participate in physiological and pathological processes. Two FAIM transcript variants have been characterized to date, namely FAIM short (FAIM-S) and FAIM long (FAIM-L). [...]
2017 - 10.1371/journal.pone.0185327
PloS one, Vol. 12 Núm. 10 (october 2017) , p. e0185327
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13 p, 1.6 MB |
Delivery is key: lessons learnt from developing splice-switching antisense therapies
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Godfrey, Caroline (University of Oxford. Department of Physiology, Anatomy and Genetics) ;
Desviat, Lourdes R (Centro de Biología Molecular Severo Ochoa UAM-CSIC) ;
Smedsrød, Bård (University of TromsØ. Department of Medical Biology) ;
Piétri-Rouxel, France (Institut de Myologie, Paris) ;
Denti, Michela A (Università di Trento. Centre for Integrative Biology) ;
Disterer, Petra (University College London. Centre for Amyloidosis and Acute Phase Proteins) ;
Lorain, Stéphanie (Institut de Myologie, Paris) ;
Nogales Gadea, Gisela (Institut Germans Trias i Pujol. Grup d'Investigació en Malalties Neuromuscular i Neuropediàtriques) ;
Sardone, Valentina (University College London) ;
Anwar, Rayan (Drug Discovery Informatics Lap, Qasemi-Research Center, Al-Qasemi Academic College) ;
EL Andaloussi, Samir (Karolinska Institute. Department of Laboratory Medicine) ;
Lehto, Taavi (University of Tartu. Institute of Technology) ;
Khoo, Bernard (University College London. Centre for Neuroendocrinology) ;
Brolin, Camilla (University of Copenhagen. Department of Cellular and Molecular Medicine) ;
van Roon-Mom, Willeke MC (Leiden University Medical Center. DEpartment of Human Genetics) ;
Goyenvalle, Aurélie (Université Versailles Saint Quentin) ;
Aartsma-Rus, Annemieke (Leiden University Medical Center. Department of Human Genetics) ;
Arechavala-Gomeza, Virginia (Neuromuscular Disorders Group. BioCruces Health Research Insitute, Bizkaia) ;
Universitat Autònoma de Barcelona
The use of splice-switching antisense therapy is highly promising, with a wealth of pre-clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. [...]
2017 - 10.15252/emmm.201607199
EMBO Molecular Medicine, Vol. 9 Núm. 5 (2017) , p. 545-557
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14 p, 1.3 MB |
Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy
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González, Carolina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Rando, Ariadna (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer Sivila, Josep (Vall d'Hebron Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 - 10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107
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