At the intersection of second language acquisition, translation, and interpretation, literacy involves identifying, choosing, and making critical-strategic use of technological resources. It also implies generating the most appropriate ones for each linguistic combination and educational or professional situation, considering the digital medium or channel in which communication takes place. From the perspective of mediation and translation, literacy involves knowing how to choose, apply, and generate technological, linguistic, and cultural resources in accordance with the conditions of communication. Our scientific challenges revolve around digital access and the use of languages; identification of sociocultural communities of an interlinguistic nature through ICTs; gender perspective, generational bias, and their identification with specific technologies; and the impact of technology on language acquisition and on the professional learning, teaching, and practice of translation and mediation.