Web of Science: 2 citas, Scopus: 3 citas, Google Scholar: citas,
GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke
Fernández Cadenas, Israel (Hospital Vall d'Hebron. Departament de Neurologia)
Mendióroz, Maite (Hospital Vall d'Hebron. Departament de Neurologia)
Giralt, Dolors (Hospital Vall d'Hebron. Departament de Neurologia)
Nafria, Cristina (Hospital Vall d'Hebron. Departament de Neurologia)
Garcia, Elena (Fundació Docència i Recerca Mutua Terrassa)
Carrera, Caty (Hospital Vall d'Hebron Departament de Neurologia)
Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mutua Terrassa)
Domingues-Montanari, Sophie (Hospital Vall d'Hebron. Departament de Neurologia)
Delgado, Pilar (Hospital Vall d'Hebron. Departament de Neurologia)
Ribó, Marc (Hospital Vall d'Hebron. Departament de Neurologia)
Castellanos, Mar (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia)
Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau)
Freijo, Mari Mar (Hospital de Basurto. Departamento de Neurologia)
Jiménez-Conde, Jordi (Hospital del Mar. Departament de Neurologia)
Rubiera, Marta (Hospital Vall d'Hebron. Departament de Neurologia)
Alvarez Sabín, José (Hospital Vall d'Hebron. Departament de Neurologia)
Molina, Carlos A. (Hospital Vall d'Hebron. Departament de Neurologia)
Font, Maria Angels (Hospital de Bellvitge. Departament de Neurologia)
Grau Olivares, Marta (Hospital Universitari Sagrat Cor. Departament de Neurologia)
Palomeras, Ernest (Hospital de Mataró. Departament de Neurologia)
Perez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia)
Masjuan, Jaime (Hospital Ramon y Cajal. Departamento de Neurologia)
Moniche, Francisco (Hospital Universitario Virgen del Rocío. Departamento de Neurologia)
Canovas, David (Corporació Sanitària Parc Taulí. Departament de Neurologia)
Piñana, Carlos (Hospital Universitario Virgen de las Nieves. Departamento de Neurologia)
Purroy, Francisco (Hospital Universitari Arnau de Vilanova. Departament de Neurologia)
Cocho, Dolores (Hospital de Granollers. Departament de Neurologia)
Navas, Inma (Hospital Mútua de Terrassa. Departament de Neurologia)
Tejero, Carlos (Hospital Clínico Universitario Lozano Blesa. Departamento de Neurologia)
Aymerich, Nuria (Hospital de Navarra. Departamento de Neurologia)
Cullell, Natalia (Fundació Docència i Recerca Mutua Terrassa)
Muiño, Elena (Fundació Docència i Recerca Mutua Terrassa)
Serena, Joaquín (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia)
Rubio, Francisco (Hospital de Bellvitge. Departament de Neurologia)
Davalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Roquer, Jaume (Hospital del Mar. Departament de Neurologia)
Arenillas Lara, Juan Francisco (Hospital Clínico Universitario de Valladolid. Departamento de Neurologia)
Martí Fábregas, Joan (Institut d'Investigació Biomèdica Sant Pau)
Keene, Keith (Center for Health Disparities. East Carolina University)
Chen, Wei-Min (Department of Public Health Sciences; Center for Public Health Genomics, University of Virginia)
Worrall, Bradford (Department of Neurology; Department of Public Health Sciences, University of Virginia)
Sale, Michele (Center for Public Health Genomics, University of Virginia)
Arboix, Adrià (Hospital Universitari Sagrat Cor. Departament de Neurologia)
Krupinski, Jerzy (Hospital Mútua de Terrassa. Departament de Neurologia)
Montaner, Joan (Hospital Vall d'Hebron. Departament de Neurologia)
GRECOSstudy group
Universitat Autònoma de Barcelona

Fecha: 2017
Resumen: Background and Purpose—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. Methods—We analyzed 256 polymorphisms from 115 candidate genes in three patient cohorts comprising 4,482 IS or TIA patients. The discovery cohort was prospectively recruited and included 1,494 patients, 6. 2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2,988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score), and generated risk groups using a classification tree method. Results—The analyses revealed that rs1800801 in the MGP gene (HR: 1. 33, p= 9×10−03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1. 305), however it was not significantly associated in a North American cohort (n=1. 683). The GRECOS score predicted new IS (p=3. 2×10−09) and could classify patients, from low risk of stroke recurrence (1. 9%) to high risk (12. 6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared to previous SPI-II score (p=0. 03). Conclusions—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
Nota: Altres ajuts: This study was funded by Marato TV3, by the Spanish stroke research network (INVICTUS-PLUS) and by Generacion project (PI15/01978) Instituto de Salud Carlos III. Dr Fernández-Cadenas is supported by the Miguel Servet program (CP12/03298), Instituto de Salud Carlos III. Several groups participate in the International Stroke Genetics Consortium and the Spanish Stroke Genetics Consortium. The Hospital del Mar is supported by Spain’s Ministry of Health (III FEDER, RD12/0042/0020). Study recruitment and collection of data sets for the VISP trial were supported by a grant (R01 NS34447; PI James Toole) from the National Institute of Neurological Disorders and Stroke (NINDS). Genome-wide association studies genotyping (U01 HG004438l; PI David Valle), funded by the National Human Genome Research Institute and the Genomics and Randomized Trials (GARNET) Network (U01HG00516-03; co-PI Michèle M. Sale and Bradford B. Worrall), and genetic data cleaning was provided by the GARNET Coordinating Center (U01HG005157; PI Bruce S. Weir)
Nota: Número d'acord de subvenció ISCIII/PI15/01978
Nota: Número d'acord de subvenció ISCIII/CP12/03298
Nota: Número d'acord de subvenció ISCIII/RD12/0042/0020
Derechos: Tots els drets reservats
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Stroke recurrence ; Genetics
Publicado en: Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153

DOI: 10.1161/STROKEAHA.116.014322
PMID: 28411264


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El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registro creado el 2018-10-10, última modificación el 2019-05-02



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