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6 p, 180.0 KB Positron emission tomography response evaluation from a randomized phase III trial of weekly nab -paclitaxel plus gemcitabine versus gemcitabine alone for patients with metastatic adenocarcinoma of the pancreas / Ramanathan, R. K. (Mayo Clinic (USA)) ; Goldstein, D. (Prince of Wales Hospital (Australia)) ; Korn, R. L. (Scottsdale Medical Imaging, Ltd (USA)) ; Arena, F. (NYU Langone Arena Oncology (USA)) ; Moore, M. (Provencial Health Services Authority. BC Cancer Agency (Canada)) ; Siena, S. (Università degli Studi di Millano. Niguarda Cancer Center (Italy)) ; Teixeira, L. (Hôpital Saint-Antoine (France)) ; Tabernero Caturla, Josep (Institut d'Oncologia de la Vall Hebron (VHIO)) ; Van Laethem, J.-L. (University Clinic of Brussels. Hôpital Erasme (Belgium)) ; Liu, H. (Biostatistics and Research and Design. Celgene Corporation (USA)) ; McGovern, D. (Biostatistics and Research and Design. Celgene Corporation (USA)) ; Lu, B. (Biostatistics and Research and Design. Celgene Corporation (USA)) ; Von Hoff, D. D. (Translational Genomics Research Institute and Honor Health (USA)) ; Universitat Autònoma de Barcelona
In a phase III pancreatic cancer study, tumor response by positron emission tomography (PET) (exploratory end point) predicted treatment efficacy, including longer overall survival. nab -Paclitaxel/gemcitabine had a significantly higher rate of metabolic response versus gemcitabine. [...]
2016 - 10.1093/annonc/mdw020
Annals of Oncology, Vol. 27, Issue 4 (April 2016) , p. 648-653  

Documents de recerca 1 registres trobats  
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80 p, 310.3 KB Telomerasa : regulación, diana terapéutica y significado clínico en neoplasias humanas / Albanell Mestres, Joan ; Baselga Torres, Josep, 1959- , dir. (Vall d'Hebron Hospitals) ; Moore, Malcolm A. S., dir.
Las células malignas deben adquirir un potencial de replicación ilimitado (inmortalidad celular) para la formación de tumores avanzados. La adquisición de inmortalidad celular depende de la reactivación de la telomerasa, una enzima que permite compensar el problema de replicación terminal del ADN asociado a cada división celular. [...]
Malignant cells have to acquire a limitless replicative potential (immortality) to be able to form an advanced tumor. The acquisition of cellular imortality is linked to the reactivation of telomerase, an enzyme that has the potential to overcome the DNA end replication problem that occurs during each round of cell división. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2002
3 documents

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1 Moore, Malcolm A. S.,
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