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14 p, 2.4 MB |
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
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Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ;
Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ;
Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ;
Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ;
Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ;
Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ;
Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ;
Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ;
Gad, Helge (The University of Sheffield) ;
Visnes, Torkild (SINTEF Industry (Noruega)) ;
Helleday, Thomas (The University of Sheffield) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 -  10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490
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33 p, 9.6 MB |
Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice
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Whittemore, Kurt (Centro Nacional de Investigaciones Oncológicas) ;
Derevyanko, Aksinya (Centro Nacional de Investigaciones Oncológicas) ;
Martínez, Paula (Centro Nacional de Investigaciones Oncológicas) ;
Serrano, Rosa (Centro Nacional de Investigaciones Oncológicas) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Blasco, María A. (Centro Nacional de Investigaciones Oncológicas)
Neurodegenerative diseases associated with old age such as Alzheimer's disease present major problems for society, and they currently have no cure. The telomere protective caps at the ends of chromosomes shorten with age, and when they become critically short, they can induce a persistent DNA damage response at chromosome ends, triggering secondary cellular responses such as cell death and cellular senescence. [...]
2019 - 10.18632/aging.101982
Aging (Albany NY), Vol. 11 (may 2019) , p. 2916-2948
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12 p, 3.3 MB |
Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes
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García Arias-Salgado, Elena (Advanced Medical Projects) ;
Gálvez, Eva (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Planas-Cerezales, Lurdes (Institut d'Investigació Biomèdica de Bellvitge) ;
Pintado-Berninches, Laura (Advanced Medical Projects) ;
Vallespín, Elena (Hospital Universitario La Paz (Madrid)) ;
Martínez, Pilar (Hospital Universitario La Paz (Madrid)) ;
Carrillo García, Jaime (Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Iarriccio, Laura (Advanced Medical Projects) ;
Ruiz-Llobet, Anna (Institut de Recerca Sant Joan de Déu) ;
Català, Albert (Institut de Recerca Sant Joan de Déu) ;
Badell Serra, Isabel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Gonzalez-Granado, Luis Ignacio (Hospital Universitario 12 de Octubre (Madrid)) ;
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galera, Ana (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Rodríguez-Vigil, Carmen (Hospital Universitario Miguel Servet (Saragossa)) ;
Bastos, Mariana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Pérez de Nanclares, Guiomar (Instituto de Investigación Sanitaria Bioaraba (Vitoria, País Basc)) ;
Leiro-Fernández, Virginia (Instituto de Investigación Biomédica de Vigo) ;
Uria Oficialdegui, Maria Luz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Valenzuela, Claudia (Hospital Universitario de la Princesa (Madrid)) ;
Martín, Sara (Institut d'Investigació Biomèdica de Bellvitge) ;
López-Muñiz, Belén (Hospital Universitario Infanta Leonor) ;
Lapunzina, Pablo (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Sevilla, Julián (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Molina Molina, Maria (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Perona, Rosario (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Sastre, Leandro (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Background: Telomeres are nucleoprotein structures present at the terminal region of the chromosomes. Mutations in genes coding for proteins involved in telomere maintenance are causative of a number of disorders known as telomeropathies. [...]
2019 - 10.1186/s13023-019-1046-0
Orphanet Journal of Rare Diseases, Vol. 14 Núm. 1 (17 2019) , p. 82
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24 p, 5.3 MB |
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
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Povedano, Juan Manuel ;
Martinez, Paula ;
Serrano, Rosa ;
Tejera, Águeda ;
Gómez-López, Gonzalo ;
Bobadilla, Maria ;
Flores, Juana Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bosch i Tubert, Fàtima ;
Blasco, María A.
Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. [...]
2018 - 10.7554/eLife.31299
eLife, Vol. 7 (january 2018)
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28 p, 1.6 MB |
Telomeres and endocrine dysfunction of the adrenal and GH/IGF-1 axes
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Aulinas, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Ramírez de Haro, Ma. José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Barahona, María-José (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Mato, Eugènia (Institut d'Investigació Biomèdica Sant Pau) ;
Bell, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Telomeres, located at the end of linear chromosomes, are essential to maintain genomic stability. Telomere biology has recently emerged as an important player in the fields of ageing and disease. To maintain telomere length (TL) and reduce its degradation after mitosis, the telomerase enzyme complex is produced. [...]
2013 - 10.1111/cen.12310
Clinical endocrinology, Vol. 79 no. 6 (Dec. 2013) , 751-9
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12 p, 1.1 MB |
Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients
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Joksic, Ivana (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ;
Vujic, Dragana (University of Belgrade. School of Medicine (Belgrad, Sèrbia)) ;
Guc-Scekic, Marija (Mother and Child Health Care Institute of Serbia "Dr Vukan Cupic" (Belgrad, Sèrbia)) ;
Leskovac, Andreja (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ;
Petrovic, Sandra (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ;
Ojani, Maryam (Brunel University (Londres, Regne Unit)) ;
Trujillo Quintero, Juan Pablo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Zivkovic, Maja (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ;
Stankovic, Aleksandra (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia)) ;
Slijepcevic, Pedrag (Brunel University (Londres, Regne Unit)) ;
Joksic, Gordana (University of Belgrade. Vinca Institute of Nuclear Sciences (Belgrad, Sèrbia))
Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed cells or animal models. [...]
2012 - 10.1186/2041-9414-3-6
Genome integrity, Vol. 3, N. 6 (September 2012) , p. 1-12
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