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1.
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13 p, 7.8 MB |
Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
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Medina-Dols, Aina (Hospital Universitari Son Espases) ;
Cañellas, Guillem (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Capó, Toni (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ;
Mola-Caminal, Marina (Uppsala University) ;
Cullell, Natalia (Institut de Recerca Sant Pau) ;
Jaume, Marina (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Nadal-Salas, Laura (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Llinàs, Jaume (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Gómez, Lluis (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Jiménez, Carmen (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Díaz, Rosa M. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Carrera, Caty (Institut de Recerca Sant Pau) ;
Muiño, Elena (Institut de Recerca Sant Pau) ;
Gallego-Fabrega, Cristina (Institut de Recerca Sant Pau) ;
Soriano Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ruiz-Guerra, Laura (Hospital Universitari Son Espases) ;
Pol-Fuster, Josep (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Asensio, Víctor (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Muncunill Farreny, Josep (Fundación Instituto de Investigación Sanitaria Islas Baleares (IdISBa)) ;
Fleischer, Aarne (Fundación Instituto de Investigación Sanitaria Islas Baleares (IdISBa)) ;
Iglesias, Amanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lazcano, Uxue (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernández-Pérez, Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jiménez-Balado, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gabriel Salazar, Marina (Hospital Universitari Vall d'Hebron) ;
García-Gabilondo, Miguel (Hospital Universitari Vall d'Hebron) ;
Lei, Ting (Hospital Universitari Vall d'Hebron) ;
Torres-Aguila, Nuria P. (Institut de Recerca Sant Pau) ;
Cárcel-Márquez, Jara (Institut de Recerca Sant Pau) ;
Lladó, Jerònia (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Olmos, Gabriel (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitario Virgen del Rocío) ;
Planas, Anna Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Rabionet, Raquel (Instituto de Salud Carlos III) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut de Recerca Sant Pau) ;
Vives-Bauzá, Cristòfol (Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS)) ;
Universitat Autònoma de Barcelona
Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial cells (ECs) in the context of stroke outcome. [...]
2024 -  10.1038/s41420-024-01857-z
Cell Death Discovery, Vol. 10 (february 2024)
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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna C. ;
Damrauer, Scott M. ;
de Vries, Paul S. ;
Smith, Nicholas L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 - 10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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7 p, 1.0 MB |
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, J. (Manchester Metropolitan University) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Molina, J. (Hospital Universitari MútuaTerrassa) ;
Besora, S. (Hospital Universitari MútuaTerrassa) ;
Sotoca, J. (Hospital Universitari MútuaTerrassa) ;
Buongiorno, María Teresa (Hospital Universitari MútuaTerrassa) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Torres-Chacón, R. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Montaner, J. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Mancha, Fernando (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Cabezas, Juan Antonio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ;
Purroy, Francisco (Hospital Universitari Arnau de Vilanova) ;
Cambray, S. (Universitat de Lleida) ;
Freijo, M.d.M. (Hospital de Basurto (Bilbao, Biscaia)) ;
Vives-Bauzá, C. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Tur, S. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Font, M.À. (Hospital Moisès Broggi) ;
López-Cancio, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ;
Calleja, Ana (Hospital Clínico Universitario de Valladolid) ;
Arenillas, Juan F (Hospital Clínico Universitario de Valladolid) ;
Rodríguez-Yáñez, M. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Castillo, J. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Sobrino, T. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, J. (Manchester Metropolitan University) ;
Universitat Autònoma de Barcelona
Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. [...]
2020 - 10.1038/s41598-020-59641-9
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 2806
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34 p, 16.2 MB |
Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ;
Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Kamanu, Frederick K. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ;
Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ;
Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ;
Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ;
Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ;
Tomppo, Liisa (Helsinki University Hospital) ;
Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ;
Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ;
Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ;
Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ;
Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Nygaard, Marianne (Odense University Hospital (Dinamarca)) ;
Leonard, Hampton L. (Data Tecnica International) ;
Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ;
Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Judy, Renae L. (University of Pennsylvania. Department of Surgery) ;
Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ;
Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Bartz, Traci M. (University of Washington. Department of Biostatistics) ;
Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ;
Bis, Joshua C (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ;
Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Ridker, Paul M. (Harvard Medical School) ;
Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ;
Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ;
Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ;
De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ;
de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ;
Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Gasca, Natalie C. (University of Washington. Department of Biostatistics) ;
Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ;
Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ;
Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Havulinna, Aki S (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ;
Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ;
Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ;
Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Jeon, Christina E. (Los Angeles County Department of Public Health) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ;
Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ;
Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Kumar, Amit (Rajendra Institute of Medical Sciences) ;
Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ;
Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ;
Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ;
Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ;
Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ;
Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ;
Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ;
Marston, Nicholas A. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ;
Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ;
Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ;
Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ;
Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ;
Nalls, Mike A. (Data Tecnica International) ;
Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ;
O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ;
Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ;
Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ;
Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ;
Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ;
Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ;
Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ;
Sabatine, Marc S. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ;
Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ;
Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ;
Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Satizabal, Claudia L. (Framingham Heart Study) ;
Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ;
Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ;
Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ;
Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ;
Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ;
Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ;
van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ;
Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ;
Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ;
Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ;
Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ;
Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ;
Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ;
Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ;
Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ;
Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ;
Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ;
Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Strbian, Daniel (Helsinki University Hospital) ;
Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ;
Adams, Hieab (Universidad Adolfo Ibáñez. Latin American Brain Health (BrainLat)) ;
Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ;
Christensen, Kaare (Odense University Hospital (Dinamarca)) ;
Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ;
Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ;
Lathrop, G. Mark (McGill Genome Centre) ;
Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ;
Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ;
França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ;
de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ;
Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ;
Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ;
Longstreth, W. T. (University of Washington. Department of Neurology) ;
Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ;
Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ;
Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ;
Chasman, Daniel I. (Harvard Medical School) ;
Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ;
Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ;
Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ;
Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ;
Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ;
Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ;
Ruff, Christian T. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ;
Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ;
Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Diseases) ;
Universitat Autònoma de Barcelona
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry ,. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. [...]
2022 - 10.1038/s41586-022-05165-3
Nature, september 2022, p. 1-15
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Publisher Correction : Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ;
Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Kamanu, Frederick K. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ;
Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ;
Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ;
Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ;
Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ;
Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ;
Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ;
Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ;
Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ;
Cárcel-Márquez, Jara (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Nygaard, Marianne (Odense University Hospital (Dinamarca)) ;
Leonard, Hampton L. (Data Tecnica International) ;
Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ;
Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Judy, Renae L. (University of Pennsylvania. Department of Surgery) ;
Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ;
Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Bartz, Traci M. (University of Washington. Department of Biostatistics) ;
Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ;
Bis, Joshua C. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ;
Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ;
Ridker, Paul M. (Harvard Medical School) ;
Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ;
Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ;
Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ;
De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ;
de Cid, Rafael (Institut Germans Trias i Pujol) ;
Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ;
Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Gasca, Natalie C. (University of Washington. Department of Biostatistics) ;
Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ;
Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ;
Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Havulinna, Aki S. (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ;
Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ;
Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ;
Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Jeon, Christina E. (Los Angeles County Department of Public Health) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ;
Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ;
Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ;
Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ;
Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ;
Kumar, Amit (Rajendra Institute of Medical Sciences) ;
Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ;
Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ;
Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ;
Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ;
Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ;
Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ;
Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ;
Marston, Nicholas A. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ;
Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ;
Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ;
Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ;
Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ;
Nalls, Mike A. (Data Tecnica International) ;
Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ;
O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ;
Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ;
Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ;
Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ;
Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ;
Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ;
Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ;
Sabatine, Marc S. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ;
Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ;
Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ;
Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ;
Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Satizabal, Claudia L. (Framingham Heart Study) ;
Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ;
Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ;
Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ;
Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ;
Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ;
Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ;
Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ;
Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ;
Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ;
van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ;
Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ;
Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ;
Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ;
Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ;
Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ;
Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ;
Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ;
Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ;
Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ;
Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ;
Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ;
Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ;
Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ;
Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ;
Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ;
Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ;
Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ;
Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ;
Adams, Hieab (Universidad Adolfo Ibáñez) ;
Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ;
Christensen, Kaare (Odense University Hospital (Dinamarca)) ;
Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ;
Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ;
Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ;
Lathrop, G. Mark (McGill Genome Centre) ;
Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ;
Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ;
Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ;
França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ;
Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ;
Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ;
Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ;
de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ;
Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ;
Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ;
Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ;
Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ;
Longstreth, W. T. (University of Washington. Department of Neurology) ;
Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ;
Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ;
Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ;
Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ;
Chasman, Daniel I. (Harvard Medical School) ;
Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ;
Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ;
Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ;
Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ;
Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ;
Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ;
Ruff, Christian T. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ;
Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ;
Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ;
Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ;
Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ;
Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Disease) ;
Universitat Autònoma de Barcelona
2022 - 10.1038/s41586-022-05492-5
Nature, Vol. 612 (november 2022) , p. E7
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6.
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17 p, 693.0 KB |
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas ;
Xu, Huichun ;
Gaynor, Brady ;
Cole, John W. ;
Rannikmae, Kristiina ;
Stanne, Tara M. ;
Tomppo, Liisa ;
Abedi, Vida ;
Amouyel, Philippe ;
Armstrong, Nicole D. ;
Attia, John ;
Bell, Steven ;
Benavente, Oscar R. ;
Boncoraglio, Giorgio B. ;
Butterworth, Adam ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Zhengming ;
Chong, Michael ;
Cruchaga, Carlos ;
Cushman, Mary ;
Danesh, John ;
Debette, Stéphanie ;
Duggan, David J. ;
Durda, Jon Peter ;
Engstrom, Gunnar ;
Enzinger, Chris ;
Faul, Jessica D. ;
Fecteau, Natalie S. ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Gieger, Christian ;
Giese, Anne-Katrin ;
Grewal, Raji P. ;
Grittner, Ulrike ;
Havulinna, Aki S. ;
Heitsch, Laura ;
Hochberg, Marc C. ;
Holliday, Elizabeth ;
Hu, Jie ;
Ilinca, Andreea ;
Irvin, Marguerite R. ;
Jackson, Rebecca D. ;
Jacob, Mina A. ;
Rabionet, Raquel ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Johnson, Julie A. ;
Kamatani, Yoichiro ;
Kardia, Sharon L.R. ;
Koido, Masaru ;
Kubo, Michiaki ;
Lange, Leslie ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Levi, Christopher R. ;
Li, Jiang ;
Li, Liming ;
Lin, Kuang ;
Lopez, Haley ;
Luke, Sothear ;
Maguire, Jane ;
McArdle, Patrick F. ;
McDonough, Caitrin W. ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Metso, Tiina ;
Müller-Nurasyid, Martina ;
Dichgans, Martin ;
O'Donnell, Martin ;
Peddareddygari, Leema R. ;
Pera, Joanna ;
Perry, James A. ;
Peters, Annette ;
Putaala, Jukka ;
Ray, Debashree ;
Rexrode, Kathryn ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosand, Jonathan ;
Rothwell, Peter M. ;
Rundek, Tatjana ;
Ryan, Kathleen A. ;
Sacco, Ralph L. ;
Salomaa, Veikko ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schmidt, Reinhold ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Smith, Jennifer A. ;
Smith, Nicholas L. ;
Wassertheil-Smoller, Sylvia ;
Söderholm, Martin ;
Stine, O. Colin ;
Strbian, Daniel ;
Sudlow, Cathie L.M. ;
Tatlisumak, Turgut ;
Terao, Chikashi ;
Thijs, Vincent ;
Torres-Aguila, Nuria P.. ;
Trégouët, David-Alexandre ;
Tuladhar, Anil M. ;
Veldink, Jan ;
Walters, Robin G. ;
Weir, David R. ;
Woo, Daniel ;
Worrall, Bradford B. ;
Hong, Charles C. ;
Ross, Owen A. ;
Zand, Ramin ;
de Leeuw, Frank-Erik ;
Lindgren, Arne G. ;
Paré, Guillaume ;
Anderson, Christopher D. ;
Markus, Hugh S. ;
Jern, Christina ;
Malik, Rainer ;
Dichgans, Martin ;
Mitchell, Braxton D. ;
Kittner, Steven J. ;
Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 - 10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754
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7.
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12 p, 1.2 MB |
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment
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Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cullell, Natalia (Mútua de Terrassa) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, Jonathan (The Manchester Metropolitan University of All Saints) ;
Olmos-Alpiste, Ferran (Parc de Salut MAR de Barcelona) ;
Espejo, Eva (Parc de Salut MAR de Barcelona) ;
March, Álvaro (Parc de Salut MAR de Barcelona) ;
Pujol Vallverdú, Ramón M.. (Parc de Salut MAR de Barcelona) ;
Rodríguez Campello, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Romeral, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Krupinski, Jurek (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric disturbances, recurrent strokes and dementia, being executive function characteristically impaired. [...]
2021 - 10.1038/s41598-021-86349-1
Scientific reports, Vol. 11 (march 2021)
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8.
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11 p, 1.9 MB |
Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ;
Persyn, Elodie (King's College London) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ;
Bakker, Mark K. (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Linxin (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Bell, Steven (Unversity of Cambridge) ;
Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ;
Tozer, Daniel J. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Griessenauer, Christoph J. (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ;
Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ;
Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Grewal, Raji P. (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ;
Lindgren, Arne (Lund University (Lund, Suècia)) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare (Helsinki, Finlàndia)) ;
Havulinna, Aki S (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ;
Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Mitchell, Braxton D. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Kittner, Steven J. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ;
Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Rost, Natalia (Massachusetts General Hospital (Boston)) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Rothwell, Peter M. (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Anderson, Christopher D. (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ;
Lewis, Cathryn M. (King's College London. Social, Genetic, and Developmental Psychiatry Centre) ;
Markus, Hugh S. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361
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9.
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21 p, 2.1 MB |
Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants
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Cullell, Natalia (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muiño, Elena (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Torres, Nuria (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Oral anticoagulants (OAs) are the recommended drugs to prevent cardiovascular events and recurrence in patients with atrial fibrillation (AF) and cardioembolic stroke. We conducted a literature search to review the current state of OAs pharmacogenomics, focusing on Genome Wide Association Studies (GWAs) in patients treated with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). [...]
2018 - 10.18632/oncotarget.25579
Oncotarget, Vol. 9 (june 2018) , p. 29238-29258
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10.
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8 p, 1.6 MB |
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
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Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
de Moura, Manuel Castro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Sanlés, Alba (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Krupinski, Jerzy ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912
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