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Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
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Vigorito, Elena (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Kuchenbaecker, Karoline B. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Beesley, Jonathan (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Adlard, Julian (Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom) ;
Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Andrulis, Irene L. (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada) ;
Arun, Banu K. (Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America) ;
Barjhoux, Laure (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Belotti, Muriel (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Berger, Andreas (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria) ;
Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark) ;
Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy) ;
Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ;
Campbell, Ian (Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia) ;
Chan, Salina B. (Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America) ;
Claes, Kathleen (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ;
Cohn, David E. (Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America) ;
Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ;
Daly, Mary B. (Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America) ;
Damiola, Francesca (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Davidson, Rosemarie (Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom) ;
De Pauw, Antoine (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Delnatte, Capucine (Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ;
Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Dworniczak, Bernd (Institute of Human Genetics, University of Münster, Münster, Germany) ;
Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Eccles, Diana M (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Edwinsdotter Ardnor, Christina (Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden) ;
Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom) ;
Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ;
Ellis, Steve (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ;
Evans, Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ;
Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ;
Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ;
Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada) ;
Friedman, Eitan (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel) ;
Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ;
Gaddam, Pragna (Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America) ;
Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America) ;
Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America) ;
García-Barberán, Vanesa (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Gauthier-Villars, Marion (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ;
Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ;
Giraud, Sophie (Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France) ;
Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ;
Goldgar, David E. (Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America) ;
Hake, Christopher R. (City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America) ;
Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ;
Healey, Sue (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Hodgson, Shirley (Medical Genetics Unit, St George's, University of London, London, United Kingdom) ;
Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands) ;
Houdayer, Claude (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America) ;
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia) ;
Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America) ;
Izatt, Louise (Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom) ;
Izquierdo, Angel (Institut d'Investigació Biomèdica de Girona) ;
Jacobs, Lauren (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America) ;
Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania) ;
Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ;
John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America) ;
Vijai, Joseph (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ;
Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ;
Investigators, KConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ;
Khan, Sofia (Helsinki University Hospital (Finlàndia)) ;
Kwong, Ava (The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China) ;
Laitman, Yael (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel) ;
Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Lesueur, Fabienne (Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France) ;
Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Mai, Phuong L. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ;
Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ;
Mazoyer, Sylvie (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ;
Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ;
Mensenkamp, Arjen R. (Radboud University Medical Centre. Department of Human Genetics) ;
Montagna, Marco (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ;
Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ;
Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America) ;
Nevanlinna, Heli (Helsinki University Hospital (Finlàndia)) ;
Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ;
Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ;
Olopade, Olufunmilayo I. (The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637) ;
Ong, Kai-ren (Birmingham Women's Hospital) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Park, Sue Kyung (Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea) ;
Paulsson-Karlsson, Ylva (Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden) ;
Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ;
Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ;
Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy) ;
Pfeiler, Georg (Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ;
Piedmonte, Marion (NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America) ;
Poppe, Bruce (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ;
Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ;
Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy) ;
Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel) ;
Rodriguez, Gustavo C. (Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America) ;
Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Ross, Eric A. (Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America) ;
Schmutzler, Rita Katharina (Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany) ;
Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Singer, Christian F. (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ;
Slavin, Thomas P. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ;
Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ;
Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia) ;
Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ;
Stoppa-Lyonnet, Dominique (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ;
Sukiennicki, Grzegorz (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ;
Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ;
Szabo, Csilla I. (National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America) ;
Tea, Muy-Kheng (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ;
Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal) ;
Teo, Soo-Hwang (Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia) ;
Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, NY, United States of America) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy) ;
Tihomirova, Laima (Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia) ;
Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ;
van Rensburg, Elizabeth J. (Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa) ;
Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy) ;
Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ;
Vratimos, Athanassios (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ;
Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ;
McGuffog, Lesley (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Kirk, Judy (Westmead Hospital) ;
Toland, Amanda Ewart (Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America) ;
Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany) ;
Lindor, Noralane (Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America) ;
Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America) ;
Greene, Mark H. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ;
Couch, Fergus J. (Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America) ;
Offit, Kenneth (Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ;
Pharoah, Paul D. P. (Department of Oncology, University of Cambridge, Cambridge, United Kingdom) ;
Chenevix-Trench, Georgia (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ;
Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Universitat Autònoma de Barcelona
Population-based genome wide association studies have identified a locus at 9p22. 2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22. [...]
2016 -  10.1371/journal.pone.0158801
PloS one, Vol. 11 (july 2016)
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