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An original phylogenetic approach identified mitochondrial haplogrou,p T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
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Blein, Sophie (Université Lyon 1) ;
Bardel, Claire (Université Claude Bernard Lyon 1) ;
Danjean, Vincent (INRIA Rhône-Alpes (França)) ;
McGuffog, Lesley (University of Cambridge) ;
Healey, Sue (QIMR Berghofer (Australia)) ;
Barrowdale, Daniel (University of Cambridge) ;
Lee, Andrew (University of Cambridge) ;
Dennis, Joe (University of Cambridge) ;
Kuchenbaecker, Karoline B. (University of Cambridge) ;
Soucy, Penny (Laval University (Canadà)) ;
Terry, Mary Beth (Columbia University) ;
Chung, Wendy (Columbia University College of Physicians and Surgeons) ;
Goldgar, David E. (University of Utah School of Medicine) ;
Buys, Saundra (University of Utah School of Medicine) ;
Janavicius, Ramunas (State Research Institute (Lituania)) ;
Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ;
Tung, Nadine (Beth Israel Deaconess Medical Center (Estats Units d'Amèrica)) ;
Dorfling, Cecilia M. (University of Pretoria) ;
van Rensburg, Elizabeth J. (University of Pretoria (Estats Units d'Amèrica)) ;
Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ;
Ding, Yuan Chun (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ;
Gerdes, Anne-Marie (Copenhagen University Hospital) ;
Ejlertsen, Bent (Copenhagen University Hospital) ;
Nielsen, Finn C. (Copenhagen University Hospital) ;
Hansen, Thomas V. O. (Copenhagen University Hospital) ;
Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Conejero, Raquel Andrés (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Segota, Ena (Clinical Cancer Genetics Community Research Network(Estats Units d'Amèrica)) ;
Weitzel, Jeffrey N. (Division of Clinical Cancer Genetics(Estats Units d'Amèrica)) ;
Thelander, Margo (Walnut Creek (Estats Units d'Amèrica)) ;
Peterlongo, Paolo (Istituto FIRC di Oncologia Molecolare) ;
Radice, Paolo (Istituto di Ricovero e Cura a Carattere Scientifico) ;
Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory (Itàlia)) ;
Dolcetti, Riccardo (Centro di Riferimento Oncologico (Itàlia)) ;
Bonanni, Bernardo (Istituto Europeo di Oncologia (Itàlia)) ;
Peissel, Bernard (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ;
Zaffaroni, Daniela (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ;
Scuvera, Giulietta (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ;
Manoukian, Siranoush (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ;
Varesco, Liliana (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ;
Capone, Gabriele L. (University of Florence, Florence) ;
Papi, Laura (University of Florence, Florence) ;
Ottini, Laura (Sapienza University) ;
Yannoukakos, Drakoulis (Aristotle University of Thessaloniki School of Medicine) ;
Konstantopoulou, Irene (Aghia Paraskevi Attikis) ;
Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Hamann, Ute (Deutsches Krebsforschungszentrum) ;
Donaldson, Alan (St Michael's Hospital) ;
Brady, Angela (Kennedy-Galton Centre) ;
Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ;
Foo, Claire (Liverpool Women's NHS Foundation Trust) ;
Evans, Gareth (Central Manchester University Hospitals NHS Foundation Trust) ;
Frost, Debra (University of Cambridge, Worts Causeway) ;
Eccles, Diana M (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Douglas, Fiona (Institute of Human Genetics, Northern Genetic Service (Regne Unit)) ;
Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ;
Adlard, Julian (Yorkshire Regional Genetics Service) ;
Barwell, Julian (Leicestershire Clinical Genetics Service) ;
Walker, Lisa (Churchill Hospital) ;
Izatt, Louise (St Thomas' NHS Foundation Trust) ;
Side, Lucy E. (Great Ormond Street Hospital for Children (Londres)) ;
Kennedy, M. John (St. James's Hospital ( Dublín, Irlanda)) ;
Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Rogers, Mark T. (University Hospital of Wales) ;
Porteous, Mary E. (Western General Hospital) ;
Morrison, Patrick J. (Belfast City Hospital, Lisburn Road) ;
Platte, Radka (University of Cambridge) ;
Eeles, Ros (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust) ;
Davidson, Rosemarie (Yorkhill Hospitals) ;
Hodgson, Shirley (St George's University of London) ;
Cole, Trevor (Birmingham Women's Hospital) ;
Godwin, Andrew K. (DUniversity of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA) ;
Isaacs, Claudine (Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20057 USA) ;
Claes, Kathleen (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ;
De Leeneer, Kim (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ;
Meindl, Alfons (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ;
Gehrig, Andrea (Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany) ;
Wappenschmidt, Barbara (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ;
Sutter, Christian (Heidelberg University Hospital (Alemanya)) ;
Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany) ;
Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ;
Steinemann, Doris (Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ;
Plendl, Hansjoerg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ;
Kast, Karin (Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany) ;
Rhiem, Kerstin (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ;
Ditsch, Nina (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ;
Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ;
Varon-Mateeva, Raymonda (Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany) ;
Schmutzler, Rita K. (German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany) ;
Preisler-Adams, Sabine (University Hospital of Münster (Alemanya)) ;
Markov, Nadja Bogdanova (University Hospital of Münster (Alemanya)) ;
Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ;
De Pauw, Antoine (Institut Curie. Department of Tumour Biology) ;
Lefol, Cédrick (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ;
Lasset, Christine (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ;
Leroux, Dominique (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ;
Rouleau, Etienne (Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210 Saint-Cloud, France) ;
Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ;
Dreyfus, Hélène (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ;
Barjhoux, Laure (Centre National de la Recherche Scientifique (França)) ;
Golmard, Lisa (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ;
Uhrhammer, Nancy (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ;
Bonadona, Valérie (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ;
Sornin, Valérie (Centre National de la Recherche Scientifique (França)) ;
Bignon, Yves-Jean (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ;
Carter, Jonathan (Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW 2050 Australia) ;
Van Le, Linda (Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC 27599-7572 USA) ;
Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263-0001 USA) ;
DiSilvestro, Paul A. (Women & Infants Hospital, 1 Blackstone Place, Providence, RI 02905 USA) ;
De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 Helsinki, Finland) ;
Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290 Helsinki, Finland) ;
Jager, Agnes (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands) ;
van den Ouweland, Ans M. W. (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands) ;
Kets, Carolien M. (Radboud University Medical Centre. Department of Human Genetics) ;
Aalfs, Cora M. (Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands) ;
van Leeuwen, Flora E. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands) ;
Meijers-Heijboer, Hanne E. J. (Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands) ;
Oosterwijk, Jan C. (Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands) ;
van Roozendaal, Kees E. P. (Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands) ;
Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Devilee, Peter (Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q Leiden, the Netherlands) ;
van der Luijt, Rob B. (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands) ;
Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122 Budapest, Hungary) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ;
Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ;
Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Del Valle, Jesús (Institut d'Investigació Biomèdica de Bellvitge) ;
Jakubowska, Anna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Sukiennicki, Grzegorz (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Gronwald, Jacek (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Lubinski, Jan (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Durda, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ;
Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Maugard, Christine (Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France) ;
Amadori, Alberto (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ;
Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ;
Teixeira, Manuel R. (Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal) ;
Spurdle, Amanda B. (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ;
Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC J2W 1S6 Canada) ;
Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ;
Lindor, Noralane M. (Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259 USA) ;
Pankratz, Vernon S. (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ;
Szabo, Csilla I (National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD 20892-2152 USA) ;
Lincoln, Anne (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ;
Jacobs, Lauren (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ;
Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ;
Robson, Mark (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ;
Vijai, Joseph (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ;
Berger, Andreas (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Fink-Retter, Anneliese (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Kaulich, Daphne Geschwantler (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Tea, Muy-Kheng (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ;
Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ;
Mai, Phuong L. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ;
Rennert, Gad (Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362 Haifa, Israel) ;
Imyanitov, Evgeny N. (NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758 St Petersburg Russia) ;
Mulligan, Anna Marie (Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8 Canada) ;
Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ;
Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8 Canada) ;
Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ;
Toland, Amanda Ewart (The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH 43210 USA) ;
Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Kruse, Torben A. (Odense University Hospital (Dinamarca)) ;
Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Caligo, Maria (Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126 Pisa, Italy) ;
Friedman, Eitan (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ;
Zidan, Jamal (Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100 Safed, Israel) ;
Laitman, Yael (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ;
Lindblom, Annika (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Melin, Beatrice (Oncology, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden) ;
Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Loman, Niklas (Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85 Lund, Sweden) ;
Rosenquist, Richard (Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden) ;
Olopade, Olufunmilayo I (Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 USA) ;
Nussbaum, Robert L. (Department of Medicine and Genetics, University of California, San Francisco, CA USA) ;
Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA 90089-9175 USA) ;
Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ;
Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ;
Rebbeck, Timothy R. (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ;
Arun, Banu K. (Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX 77230-1439 USA) ;
Mitchell, Gillian (Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010 VIC Australia) ;
Karlan, Beth Y (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Orsulic, Sandra (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ;
Stoppa-Lyonnet, Dominique (Université Paris Descartes) ;
Thomas, Gilles (Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, Cedex 08 France) ;
Simard, Jacques (Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ Canada) ;
Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ;
Offit, Kenneth (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ;
Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ;
Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Mazoyer, Sylvie (Université Lyon 1, 69100 Villeurbanne, France) ;
Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA) ;
Sinilnikova, Olga M. (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373 Lyon, Cedex 08 France) ;
Cox, David G. (Université Lyon 1, 69100 Villeurbanne, France) ;
Universitat Autònoma de Barcelona
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. [...]
2015 -  10.1186/s13058-015-0567-2
Breast cancer research, Vol. 17 (april 2015)
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18 p, 1.0 MB |
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers
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Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Kuchenbaecker, Karoline (University of Cambridge) ;
Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ;
Wang, Xianshu (Mayo Clinic, Rochester, United States of America) ;
Barrowdale, Daniel (University of Cambridge) ;
de Garibay, Gorka Ruiz (Institut d'Investigació Biomèdica de Bellvitge) ;
Librado, Pablo (Universitat de Barcelona) ;
Sánchez-Gracia, Alejandro (Universitat de Barcelona) ;
Rozas, Julio (Universitat de Barcelona) ;
Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
McGuffog, Lesley (University of Cambridge) ;
Pankratz, Vernon S. (Mayo Clinic, Rochester, Minnesota) ;
Islam, Abul (University of Dhaka) ;
Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ;
Berenguer-Llergo, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ;
Petit Montserrat, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Català, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ;
Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ;
Feliubadaló, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ;
Tornero, Eva (Institut d'Investigació Biomèdica de Bellvitge) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Aittomäki, Kristiina (Helsinki University Central Hospital) ;
Arun, Banu K. (University of Texas) ;
Toland, Amanda E. (The Ohio State University, Columbus) ;
Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ;
Greene, Mark H. (National Cancer Institute, Maryland, Rockville) ;
Mai, Phuong L. (National Cancer Institute, Maryland, Rockville) ;
Nussbaum, Robert L. (University of California San Francisco, San Francisco) ;
Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ;
Domchek, Susan M. (The University of Pennsylvania School of Medicine, Philadelphia) ;
Nathanson, Katherine L. (The University of Pennsylvania School of Medicine, Philadelphia) ;
Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ;
Barkardottir, Rosa B. (Landspitali University Hospital (Reykjavík, Islàndia)) ;
Jakubowska, Anna (Pomeranian Medical University, Szczecin) ;
Lubinski, Jan (Pomeranian Medical University, Szczecin) ;
Durda, Katarzyna (Pomeranian Medical University, Szczecin) ;
Jaworska-Bieniek, Katarzyna (Pomeranian Medical University, Szczecin) ;
Claes, Kathleen (Ghent University, Ghent) ;
Van Maerken, Tom (Ghent University, Ghent) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Hansen, Thomas V. (Copenhagen University Hospital) ;
Jønson, Lars (Copenhagen University Hospital) ;
Gerdes, Anne-Marie (Copenhagen University Hospital) ;
Ejlertsen, Bent (Copenhagen University Hospital) ;
De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Dunning, Alison M. (University of Cambridge) ;
Oliver, Clare (University of Cambridge) ;
Fineberg, Elena (University of Cambridge) ;
Cook, Margaret (University of Cambridge) ;
Peock, Susan (University of Cambridge) ;
McCann, Emma (Glan Clwyd Hospital, Rhyl) ;
Murray, Alex (Singleton Hospital, Swansea) ;
Jacobs, Chris (Guy's and St. Thomas' National Health Service, London) ;
Pichert, Gabriella (Guy's and St. Thomas' National Health Service, London) ;
Lalloo, Fiona (Central Manchester University Hospitals National Health Service, Manchester) ;
Chu, Carol (Yorkshire Regional Genetics Service, Leeds) ;
Dorkins, Huw (Kennedy-Galton Centre, Harrow) ;
Paterson, Joan (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Ong, Kai-Ren (Birmingham Women's Hospital) ;
Teixeira, Manuel R. (Universidade do Porto) ;
Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
van der Hout, Annemarie H. (University of Groningen) ;
Seynaeve, Caroline (Erasmus University Medical Center, Rotterdam) ;
van der Luijt, Rob B. (University Medical Center Utrecht, Utrecht) ;
Ligtenberg, Marjolijn J. L. (Radboud university medical center, Nijmegen) ;
Devilee, Peter (Leiden University Medical Center, Leiden) ;
Wijnen, Juul T. (Leiden University Medical Center, Leiden) ;
Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Meijers-Heijboer, Hanne E. J. (Vrije Universiteit, Amsterdam) ;
Blok, Marinus J. (Maastricht University Medical Center) ;
van den Ouweland, Ans M. W. (Erasmus University Medical Center, Rotterdam) ;
Aalfs, Cora M. (Department of Clinical Genetics, Amsterdam) ;
Rodriguez, Gustavo C. (University of Chicago) ;
Phillips, Kelly-Anne A. (Peter MacCallum Cancer Centre, East Melbourne) ;
Piedmonte, Marion (Roswell Park Cancer Institute, Buffalo, New York) ;
Nerenstone, Stacy R. (Hartford Hospital/Helen and Harry Gray Cancer Center) ;
Bae-Jump, Victoria L. (University of North Carolina) ;
O'Malley, David M. (Ohio State University, Hilliard) ;
Ratner, Elena S. (Yale University School of Medicine) ;
Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya)) ;
Wappenschmidt, Barbara (Uniklinik Köln (Colònia, Alemanya)) ;
Rhiem, Kerstin (University Hospital of Cologne, Cologne, Germany) ;
Engel, Christoph (University of Leipzig) ;
Meindl, Alfons (Technical University Munich) ;
Ditsch, Nina (Ludwig-Maximilian University Munich) ;
Arnold, Norbert (Kiel University Medical Center Schleswig-Holstein) ;
Plendl, Hansjoerg J. (Kiel University Medical Center Schleswig-Holstein) ;
Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ;
Sutter, Christian (Heidelberg University Hospital (Alemanya)) ;
Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ;
Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover) ;
Preisler-Adams, Sabine (University of Münster) ;
Kast, Karin (Technical University Dresden) ;
Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin) ;
Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ;
Bojesen, Anders (Vejle Hospital, Vejle) ;
Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ;
Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Thomassen, Mads (Odense University Hospital (Dinamarca)) ;
Kruse, Torben A. (Odense University Hospital (Dinamarca)) ;
Foretova, Lenka (Masaryk Memorial Cancer Institute (Brno, República Txeca)) ;
Peterlongo, Paolo (Fondazione Istituto di Oncologia MolecolarE, Milan) ;
Bernard, Loris (Istituto Europeo di Oncologia, Milan) ;
Peissel, Bernard (Fondazione Istituto Nazionale Tumori, Milan) ;
Scuvera, Giulietta (Fondazione Istituto Nazionale Tumori, Milan) ;
Manoukian, Siranoush (Fondazione Istituto Nazionale Tumori, Milan) ;
Radice, Paolo (Fondazione Istituto Nazionale Tumori, Milan) ;
Ottini, Laura ("Sapienza" University, Rome) ;
Montagna, Marco (Istituto Oncologico Veneto, Padua) ;
Agata, Simona (Istituto Oncologico Veneto, Padua) ;
Maugard, Christine (Hopitaux Universitaire de Strasbourg) ;
Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ;
Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ;
Berger, Andreas (Medical University of Vienna) ;
Fink-Retter, Anneliese (Medical University of Vienna) ;
Singer, Christian F. (Medical University of Vienna) ;
Rappaport, Christine (Medical University of Vienna) ;
Geschwantler-Kaulich, Daphne (Medical University of Vienna) ;
Tea, Muy-Kheng (Medical University of Vienna) ;
Pfeiler, Georg (Medical University of Vienna) ;
John, Esther M. (Cancer Prevention Institute of California) ;
Miron, Alex (Dana-Farber Cancer Institute, Boston, Massachusetts) ;
Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ;
Terry, Mary Beth (Columbia University) ;
Chung, Wendy (Columbia University) ;
Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania) ;
Goldgar, David E. (University of Utah School of Medicine, Salt Lake City) ;
Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ;
Dorfling, Cecilia M. (University of Pretoria, Arcadia) ;
van Rensburg, Elisabeth J. (University of Pretoria, Arcadia) ;
Fostira, Florentia (National Centre for Scientific Research Demokritos, Athens) ;
Konstantopoulou, Irene (National Centre for Scientific Research Demokritos, Athens) ;
Garber, Judy (Harvard Medical School, Boston) ;
Godwin, Andrew K. (University of Kansas Medical Center, Kansas City) ;
Olah, Edith (National Institute of Oncology, Budapest) ;
Narod, Steven A. (University of Toronto) ;
Rennert, Gad (Clalit National Israeli Cancer Control Center) ;
Paluch, Shani Shimon (Chaim Sheba Medical Center, Ramat Gan) ;
Laitman, Yael (Institute of Human Genetics, Ramat Gan) ;
Friedman, Eitan (Tel Aviv University, Ramat Aviv) ;
Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Stenmark-Askmalm, Marie (Linköping University, Sweeden) ;
Loman, Niklas (Lund University Hospital, Sweeden) ;
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg) ;
Hamann, Ute (German Cancer Research Center (DKFZ), Heidelberg) ;
Spurdle, Amanda B. (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ;
Healey, Sue (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ;
Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California) ;
Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California) ;
Margileth, David (St. Joseph Hospital of Orange, Duarte, California) ;
Gorrini, Chiara (University Health Network, Toronto) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Gómez Moruno, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ;
Sayols, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ;
Vidal, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ;
Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ;
Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ;
Léoné, Melanie (Hospices Civils de Lyon-Centre Léon Bérard, Lyon) ;
Barjhoux, Laure (Université Lyon 1) ;
Fassy-Colcombet, Marion (Institut Curie, Paris) ;
De Pauw, Antoine (Institut Curie, Paris) ;
Lasset, Christine (Université Lyon 1) ;
Ferrer, Sandra Fert (Hôtel Dieu Centre Hospitalier, Chambéry) ;
Castera, Laurent (Department of Tumour Biology, Institut Curie, Paris) ;
Berthet, Pascaline (Centre François Baclesse, Caen, France) ;
Cornelis, François (Genetic Unit, Avicenne Hospital, Clermont-Ferrand) ;
Bignon, Yves-Jean (Université de Clermont-Ferrand) ;
Damiola, Francesca (Centre de Recherche en Cancérologie de Lyon) ;
Mazoyer, Sylvie (Centre de Recherche en Cancérologie de Lyon) ;
Sinilnikova, Olga M. (Centre de Recherche en Cancérologie de Lyon) ;
Maxwell, Christopher A. (University of British Columbia, Vancouver) ;
Vijai, Joseph (Memorial Sloan-Kettering Cancer Center, New York) ;
Robson, Mark (Memorial Sloan-Kettering Cancer Center, New York) ;
Kauff, Noah (Memorial Sloan-Kettering Cancer Center, New York) ;
Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ;
Villano, Danylko (Memorial Sloan-Kettering Cancer Center, New York) ;
Cunningham, Julie M. (Mayo Clinic, Rochester, Minnesota, United States of America) ;
Lee, Adam (Mayo Clinic, Rochester, Minnesota) ;
Lindor, Noralane (Mayo Clinic, Scottsdale, Arizona) ;
Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ;
Easton, Douglas F. (University of Cambridge) ;
Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, New York) ;
Chenevix-Trench, Georgia (Queensland Institute of Medical Research, Brisbane, Australia) ;
Couch, Fergus J. (Mayo Clinic, Rochester, Minnesota) ;
Antoniou, Antonis C. (University of Cambridge) ;
Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge)
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. [...]
2015 - 10.1371/journal.pone.0120020
PloS one, Vol. 10 (april 2015)
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