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1.
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22 p, 8.7 MB |
Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
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Waryah, Charlene (University of Western Australia) ;
Cursons, Joseph (Monash University, Australia) ;
Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ;
Pflueger, Christian (University of Western Australia) ;
Wang, Edina (University of Western Australia) ;
Molania, Ramyar (University of Melbourne, Australia) ;
Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ;
Sorolla, Anabel (University of Western Australia) ;
Wallis, Christopher (University of Western Australia) ;
Moses, Colette (University of Amsterdam, The Netherlands) ;
Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ;
Magalhães, Leandro (University of Pará, Brazil) ;
Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ;
Fearnley, Liam G. (University of Melbourne, Australia) ;
Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ;
Davis, Melissa (University of Melbourne, Australia) ;
Papenfuss, Anthony T. (University of Melbourne, Australia) ;
Redfern, Andrew (University of Western Australia) ;
Lister, Ryan (The University of Western Australia) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 -  10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)
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2.
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18 p, 4.0 MB |
Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice
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García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ordoño, Jesus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Odendaal, Karla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
We have previously demonstrated that the post-stroke administration of iron-free transferrin (apotransferrin, ATf) is beneficial in different models of ischemic stroke (IS) through the inhibition of the neuronal uptake of pro-oxidant iron. [...]
2023 - 10.3390/antiox12111945
Antioxidants, Vol. 12 Núm. 11 (October 2023)
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3.
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14 p, 1.7 MB |
Influence of Malignant Pleural Fluid from Lung Adenocarcinoma Patients on Neutrophil Response
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Mulet Gual, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Osuna Gómez, Rubén (Institut d'Investigació Biomèdica Sant Pau) ;
Zamora, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Porcel, José M. (Hospital Universitari Arnau de Vilanova) ;
Nieto Sáchica, Juan Camilo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Perea, Lídia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Pajares Ruiz, Virginia (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Fernandez, Ana M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Calvo, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Sorolla, Maria Alba (Institut de Recerca Biomèdica de Lleida. Research Group of Cancer Biomarkers) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Malignant pleural effusion (MPE) is a common severe complication of advanced lung ad-enocarcinoma (LAC). Neutrophils, an essential component of tumor infiltrates, contribute to tumor progression and their counts in MPE have been associated with worse outcome in LAC. [...]
2022 - 10.3390/cancers14102529
Cancers, Vol. 14 Núm. 10 (May 2022) , p. 2529
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4.
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16 p, 7.7 MB |
Establishment of a reproducible and minimally invasive ischemic stroke model in swine
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Castaño Duque, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Sort, Maria Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls-Carbó, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pino, Osvaldo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Grífols, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iruela-Sánchez, Alba (Canon Medical Systems) ;
Palomar-García, Alicia (Canon Medical Systems) ;
Puig, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The need for advances in the management/treatment options for ischemic stroke patients requires that upcoming preclinical research uses animals with more human-like brain characteristics. The porcine brain is considered appropriate, although the presence of the rete mirabile (RM) prevents direct catheterization of the intracranial arteries to produce focal cerebral ischemia. [...]
2023 - 10.1172/jci.insight.163398
JCI Insight, Vol. 8 (april 2023)
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5.
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14 p, 2.6 MB |
Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids
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Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III) ;
Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz) ;
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Valero, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Olaguibel, José M. (Complejo Hospitalario de Navarra) ;
Del Pozo, Victoria (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. [...]
2023 - 10.3390/ijms24021611
International journal of molecular sciences, Vol. 24 (january 2023)
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6.
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16 p, 6.4 MB |
JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis
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Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lorente-Sorolla, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calafell-Segura, Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Sanmartín, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Rodriguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. [...]
2021 - 10.3389/fimmu.2021.734652
Frontiers in immunology, Vol. 12 (november 2021) , p. 734652
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7.
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21 p, 4.5 MB |
Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation
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De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guirao, Verónica (Institut Germans Trias i Pujol) ;
Ponce, Jovita (Institut Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol) ;
Aliena-Valero, Alicia (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ;
García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salom, Juan B. (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to interact with the excitotoxicity driver NMDA receptor (NMDAR), and in sudden pathophysiological conditions of the brain, e. [...]
2020 - 10.3390/antiox9121202
Antioxidants, Vol. 9 Núm. 12 (2020) , p. 1202
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8.
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30 p, 861.2 KB |
Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation
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Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol) ;
Rodríguez-Esparragoza, Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol) ;
Castaño Duque, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals with interesting brain characteristics and wide social acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. [...]
2020 - 10.3390/ijms21186568
International journal of molecular sciences, Vol. 21 Núm. 18 (2020) , p. 6568
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9.
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18 p, 4.3 MB |
Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis
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Lorente-Sorolla, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Toledano, Víctor (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Avendaño-Ortiz, José (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Maroun-Eid, Charbel (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martín-Quirós, Alejandro (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Sanmartín, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Campo, Álvaro García (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut d'Investigació Biomèdica de Bellvitge) ;
Vall d'Hebron Institut de Recerca (VHIR)
Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation. [...]
2019 - 10.1186/s13073-019-0674-2
Genome Medicine, Vol. 11 (october 2019)
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