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36 p, 4.7 MB |
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
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García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ;
Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ;
Dietmann, Sabine (Washington University School of Medicine in St. Lou) ;
López, Judith (Instituto de Investigación Biomédica de Salamanca) ;
Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ;
D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ;
Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Paniagua, Alejandro (Universidad de Salamanca) ;
Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ;
Marchand, Virginie (Université de Lorraine, France) ;
Alonso-López, Diego (Universidad de Salamanca) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Tuñón, Ignacio (Universidad de Salamanca) ;
Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ;
Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ;
Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ;
Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ;
Sánchez-Martín, Manuel A. (Universidad de Salamanca) ;
De Las Rivas, Javier (Universidad de Salamanca) ;
Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Motorin, Yuri (Université de Lorrain) ;
Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ;
Pandolfi, Pier Paolo (University of Turin, Italy) ;
Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ;
Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 -  10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)
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11 p, 1.1 MB |
Immune responses following neonatal vaccination with conserved F4 fragment of VtaA proteins from virulent Glaesserella parasuis adjuvanted with CAF®01 or CDA
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López-Serrano, Sergi (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Mahmmod, Yasser S. (Al Ain Men's College. Section of Veterinary Sciences) ;
Christensen, Dennis (Statens Serum Institut. Department of Infectious Disease Immunology) ;
Ebensen, Thomas (Helmholtz Centre for Infection Research. Department of Vaccinology and Applied Microbiology) ;
Guzmán, Carlos A. (Helmholtz Centre for Infection Research. Department of Vaccinology and Applied Microbiology) ;
Rodríguez Rey, Fernando (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Aragon, Virginia (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Glaesserella parasuis is a Gram-negative bacterium that colonizes the upper airways of swine, capable of causing a systemic infection called Glässer's disease. This disease is more frequent in young post-weaning piglets. [...]
2023 - 10.1016/j.jvacx.2023.100330
Vaccine: X, Vol. 14 (june 2023)
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7 p, 591.2 KB |
A Silylene stabilized by a σ-donating Ni(0) fragment
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Frutos, María (Centre National de la Recherche Scientifique. Université de Toulouse. Laboratoire Hétérochimie Fondamentale et Appliquée) ;
Parvin, Nasrina (Centre National de la Recherche Scientifique. Université de Toulouse. Laboratoire Hétérochimie Fondamentale et Appliquée) ;
Baceiredo, Antoine (Centre National de la Recherche Scientifique. Université de Toulouse. Laboratoire Hétérochimie Fondamentale et Appliquée) ;
Madec, David (Centre National de la Recherche Scientifique. Université de Toulouse. Laboratoire Hétérochimie Fondamentale et Appliquée) ;
Saffon-Merceron, Nathalie (Centre National de la Recherche Scientifique. Université de Toulouse. Institut de Chimie de Toulouse) ;
Branchadell Gallo, Vicenç (Universitat Autònoma de Barcelona. Departament de Química) ;
Kato, Tsuyoshi (Centre National de la Recherche Scientifique. Université de Toulouse. Laboratoire Hétérochimie Fondamentale et Appliquée)
A donor-stabilized silylene 4 featuring a Ni0-based donating ligand was synthesized. Complex 4 exhibits a pyramidalized and nucleophilic SiII center and shows a peculiar behavior due to the cooperative reactivity of Si and Ni centers. [...]
2022 - 10.1002/anie.202201932
Angewandte Chemie (International ed. Internet), (May 2022), art. e202201932
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11 p, 14.5 MB |
Fragment C Domain of Tetanus Toxin Mitigates Methamphetamine Neurotoxicity and Its Motor Consequences in Mice
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Mendieta, Liliana (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Granado, Noelia (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Tizabi, Yousef (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Moratalla, Rosario (Instituto Cajal, Consejo Superior de Investigaciones Científicas, CSIC) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson's disease. [...]
2016 - 10.1093/ijnp/pyw021
International journal of neuropsychopharmacology, Vol. 19 (march 2016)
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18 p, 8.6 MB |
Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides
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Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mulder, Sandra D. (VU University Medical Center. Clinical Chemistry Department) ;
Veerhuis, Robert (VU University Medical Center. Psychiatry Department) ;
Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aβ-Immunotherapy has long been studied in the treatment of Alzheimer's disease (AD), but not how other molecules involved in the disease can affect antibody performance. We previously designed an antibody fragment, scFv-h3D6, and showed that it precludes Aβ-induced cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway towards a non-toxic, worm-like pathway. [...]
2017 - 10.1371/journal.pone.0188191
PloS one, Vol. 12, Issue 11 (November 2017) , art. e0188191
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19 p, 18.6 MB |
Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect
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Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Bronsoms, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ;
Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
ScFv-h3D6 has been shown as an efficient therapy in the 3xTg-AD mouse model of Alzheimer's Disease. Because one of the major bottlenecks for the therapeutic uses of proteins produced in Escherichia coli is their potential contamination with endotoxins, LPS were extensively removed by a rather low-efficient, expensive, and time-consuming purification step. [...]
2017 - 10.1371/journal.pone.0181480
PloS one, Vol. 12 (August 2017) , art. e0181480
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14 p, 1.3 MB |
Sow vaccination with a protein fragment against virulent glaesserella (Haemophilus) parasuis modulates immunity traits in their offspring
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López-Serrano, Sergi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Neila-Ibáñez, Carlos María (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Costa-Hurtado, Mar (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Mahmmod, Yasser (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Martínez-Martínez, Jorge (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Galindo Cardiel, Iván (Parque Magnus-Polígono Empresarium. WorldPathol) ;
Darji, Ayub (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rodriguez, Fernando (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Sibila, Marina (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Aragon, Virginia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. [...]
2021 - 10.3390/vaccines9050534
Vaccines (Basel), Vol. 9 Núm. 5 (may 2021) , p. 534
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10 p, 1.2 MB |
Neuroprotective fragment C of tetanus toxin modulates IL-6 in an ALS mouse model
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Moreno-Martinez, L. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
De La Torre, M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Muñoz, M. J. (Universidad de Zaragoza. Centro de Investigación Biomédica en Red Sobre Enfermedades) ;
Zaragoza, Pilar (Universidad de Zaragoza. Centro de Investigación Biomédica en Red Sobre Enfermedades) ;
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Calvo, Ana Cristina (Universidad de Zaragoza. Centro de Investigación Biomédica en Red Sobre Enfermedades) ;
Osta, R. (Universidad de Zaragoza. Centro de Investigación Biomédica en Red Sobre Enfermedades)
Neuroinflammation plays a significant role in amyotrophic lateral sclerosis (ALS) pathology, leading to the development of therapies targeting inflammation in recent years. Our group has studied the tetanus toxin C-terminal fragment (TTC) as a therapeutic molecule, showing neuroprotective properties in the SOD1G93A mouse model. [...]
2020 - 10.3390/toxins12050330
Toxins, Vol. 12 Núm. 5 (may 2020) , p. 330
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